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MeSH Review

Dermatitis, Irritant

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Disease relevance of Dermatitis, Irritant


High impact information on Dermatitis, Irritant

  • RESULTS: The most common clinical presentation of latex allergy is a nonimmunologic, irritant dermatitis of the hand [6].
  • Prednicarbate and its vehicle, however, do not reverse irritant dermatitis [7].
  • Intriguingly, ITZ failed to suppress the irritant dermatitis induced by croton oil or benzalkonium chloride, suggesting that it may affect molecule(s) rather selectively involved in the elicitation of CHS [8].
  • Irritant dermatitis was induced by applying phorbol 12-myristate-13-acetate (TPA) to the surface of the ears of CD1 mice, followed by treatment with 22ROH, 25OH, GW3965, or vehicle alone [9].
  • Penetration was monitored at four locations: in normal (unmodified) skin and in skin with perturbed barrier function from (i) repeated tape stripping (ii) irritant dermatitis from 1 or 2% sodium lauryl sulphate (SLS) for 24 h and (iii) delipidization by acetone [10].

Chemical compound and disease context of Dermatitis, Irritant


Biological context of Dermatitis, Irritant


Anatomical context of Dermatitis, Irritant

  • These findings suggest that contact allergens and irritants probably upregulate VEGF in keratinocytes by different mechanisms and may contribute directly to the microvascular hyperpermeability which characterizes both contact and irritant dermatitis [17].

Gene context of Dermatitis, Irritant


  1. Removal of the majority of epidermal Langerhans cells by topical or systemic steroid application enhances the effector phase of murine contact hypersensitivity. Grabbe, S., Steinbrink, K., Steinert, M., Luger, T.A., Schwarz, T. J. Immunol. (1995) [Pubmed]
  2. Clinical trial of bleaching treatment with 10% all-trans retinol gel. Yoshimura, K., Momosawa, A., Aiba, E., Sato, K., Matsumoto, D., Mitoma, Y., Harii, K., Aoyama, T., Iga, T. Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]. (2003) [Pubmed]
  3. Reduced skin threshold to irritation in the presence of allergic contact dermatitis in the guinea pig. Arlette, J.P., Fritzler, M.J. Contact Derm. (1984) [Pubmed]
  4. Dyshidrotic eczema as an occupational dermatitis in metal workers. de Boer, E.M., Bruynzeel, D.P., van Ketel, W.G. Contact Derm. (1988) [Pubmed]
  5. The use of therapeutic moisturizers in various dermatologic disorders. Bikowski, J. Cutis; cutaneous medicine for the practitioner. (2001) [Pubmed]
  6. Allergy to latex rubber. Sussman, G.L., Beezhold, D.H. Ann. Intern. Med. (1995) [Pubmed]
  7. Prednicarbate activity and benefit/risk ratio in relation to other topical glucocorticoids. Schäfer-Korting, M., Korting, H.C., Kerscher, M.J., Lenhard, S. Clin. Pharmacol. Ther. (1993) [Pubmed]
  8. Itraconazole suppresses an elicitation phase of a contact hypersensitivity reaction. Ausaneya, U., Kawada, A., Aragane, Y. J. Invest. Dermatol. (2006) [Pubmed]
  9. Liver X receptor activators display anti-inflammatory activity in irritant and allergic contact dermatitis models: liver-X-receptor-specific inhibition of inflammation and primary cytokine production. Fowler, A.J., Sheu, M.Y., Schmuth, M., Kao, J., Fluhr, J.W., Rhein, L., Collins, J.L., Willson, T.M., Mangelsdorf, D.J., Elias, P.M., Feingold, K.R. J. Invest. Dermatol. (2003) [Pubmed]
  10. Effect of barrier perturbation on cutaneous salicylic acid penetration in human skin: in vivo pharmacokinetics using microdialysis and non-invasive quantification of barrier function. Benfeldt, E., Serup, J., Menné, T. Br. J. Dermatol. (1999) [Pubmed]
  11. Susceptibility to irritant dermatitis induced by sodium lauryl sulfate. Wilhelm, K.P., Maibach, H.I. J. Am. Acad. Dermatol. (1990) [Pubmed]
  12. Effect of BN 52021, a platelet activating factor antagonist, on dithranol-induced inflammation. Kemény, L., Csató, M., Braquet, P., Dobozy, A. Br. J. Dermatol. (1990) [Pubmed]
  13. Arachidonic acid metabolism in primary irritant dermatitis produced by patch testing of human skin with surfactants. Müller-Decker, K., Heinzelmann, T., Fürstenberger, G., Kecskes, A., Lehmann, W.D., Marks, F. Toxicol. Appl. Pharmacol. (1998) [Pubmed]
  14. Effects of intensive application of retinoic acid on human skin. Kaidbey, K.H., Kligman, A.M., Yoshida, H. Br. J. Dermatol. (1975) [Pubmed]
  15. Treatment-resistant alopecia areata. Response to combination therapy with minoxidil plus anthralin. Fiedler, V.C., Wendrow, A., Szpunar, G.J., Metzler, C., DeVillez, R.L. Archives of dermatology. (1990) [Pubmed]
  16. Electrical impedance measured to five skin depths in mild irritant dermatitis induced by sodium lauryl sulphate. Nicander, I., Ollmar, S., Rozell, B.L., Eek, A., Emtestam, L. Br. J. Dermatol. (1995) [Pubmed]
  17. Contact allergens and sodium lauryl sulphate upregulate vascular endothelial growth factor in normal keratinocytes. Palacio, S., Schmitt, D., Viac, J. Br. J. Dermatol. (1997) [Pubmed]
  18. Fish scale-induced dermatitis. Chiou, F.Y., Tschen, J.A. J. Am. Acad. Dermatol. (1993) [Pubmed]
  19. Cumulative irritant dermatitis and abnormal epidermal plasminogen activator activity: what connection? Lotti, T., Bonan, P., Panconesi, E. International journal of dermatology. (1989) [Pubmed]
  20. The hairless guinea-pig as a model for treatment of cumulative irritation in humans. Andersen, F., Hedegaard, K., Petersen, T.K., Bindslev-Jensen, C., Fullerton, A., Andersen, K.E. Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI). (2006) [Pubmed]
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