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Chemical Compound Review

Timoptic     but-2-enedioic acid; (2S)-1-[(4-morpholin...

Synonyms: Blocadren, Timacor, Betime, Timoptic?XE, Blocadren (TN), ...
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Disease relevance of Blocadren


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Biological context of Blocadren


Anatomical context of Blocadren


Associations of Blocadren with other chemical compounds

  • A similar percentage of patients in the Timolol GFS 0.5% group (71%) and Timoptic XE group (72%) had clinically relevant reductions in intraocular pressure [1].
  • Recently, ongoing clinical comparison trials of up to three years in length have reported sustained intraocular pressure (IOP) lowering efficacy with brimonidine 0.2% b.i.d., which was comparable with timolol 0.5% (Timoptic; Merck & Co.), accompanied by a favourable tolerability and safety profile [11].
  • The pH changes after Timoptol, Xalatan and Pilocarpine showed a similar time pattern and after return to the baseline values the pH shifted to alkaline levels [12].


  1. Long-term intraocular pressure-lowering efficacy and safety of timolol maleate gel-forming solution 0.5% compared with Timoptic XE 0.5% in a 12-month study. Schenker, H.I., Silver, L.H. Am. J. Ophthalmol. (2000) [Pubmed]
  2. Timolol maleate (blocadren) in the treatment of hypertension. Levitt, D. East African medical journal. (1977) [Pubmed]
  3. Timolol increased retrobulbar flow velocities in untreated glaucoma eyes but not in ocular hypertension. Bergstrand, I.C., Heijl, A., Wollmer, P., Hansen, F., Harris, A. Acta ophthalmologica Scandinavica. (2001) [Pubmed]
  4. Attempt to arrest eye growth by means of ocular hypotony. Nastri, G., Cennamo, G., Caruso, C. Metabolic, pediatric, and systemic ophthalmology (New York, N.Y. : 1985) (1985) [Pubmed]
  5. Comparison of the postoperative intraocular pressure with Betagan, Betoptic, Timoptic, Iopidine, Diamox, Pilopine Gel, and Miostat. Fry, L.L. Journal of cataract and refractive surgery. (1992) [Pubmed]
  6. Effects of timoptic on corneal reepithelialization. O'Brien, W.J., DeCarlo, J.D., Stern, M., Hyndiuk, R.A. Arch. Ophthalmol. (1982) [Pubmed]
  7. Effect of iontophoresis on transcorneal permeation 'in vitro' of two beta-blocking agents, and on corneal hydration. Monti, D., Saccomani, L., Chetoni, P., Burgalassi, S., Saettone, M.F. International journal of pharmaceutics. (2003) [Pubmed]
  8. Ultrastructural changes of the rabbit corneal epithelium and endothelium after Timoptic treatment. Liu, G.S., Basu, P.K., Trope, G.E. Graefes Arch. Clin. Exp. Ophthalmol. (1987) [Pubmed]
  9. Haemodynamic and metabolic effects of timolol (Blocadren) on ischaemic myocardium. Simonsen, S., Ihlen, H., Kjekshus, J.K. Acta medica Scandinavica. (1983) [Pubmed]
  10. Toxic effects of topically administered Betagan, Betoptic, and Timoptic on regenerating corneal epithelium. Trope, G.E., Liu, G.S., Basu, P.K. Journal of ocular pharmacology. (1988) [Pubmed]
  11. The evolving pharmacotherapeutic profile of brimonidine, an alpha 2-adrenergic agonist, after four years of continuous use. Cantor, L.B. Expert opinion on pharmacotherapy. (2000) [Pubmed]
  12. The free amino acids and the aqueous humor pH after antiglaucomatics in vitro. Veselovsky, J., Olah, Z., Vesela, A., Gressnerova, S. Bratislavské lekárske listy. (2003) [Pubmed]
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