Disease relevance of Diacarb

• RESULTS: Cerebral vasomotor reactivity was estimated as good (> 40% increase of blood flow velocity in the middle cerebral artery ipsilateral to the carotid stenosis after undergoing the Diamox test) in 23 patients; it was impaired in the other 21 [1].
• 2. Experiments were performed in control rats, in animals undergoing metabolic acidosis or alkalosis and in control and acidotic rats receiving the carbonic anydrase inhibitor Diamox [2].
• 5. Acidification half-times were prolonged in metabolic acidosis and after Diamox but remained similar to control levels in metabolic alkalosis [2].
• A cisternogram characteristic of normal-pressure hydrocephalus was obtained from a patient on Diamox who was being evaluated for rapid mental deterioration [3].
• In one patient with hyperkalemic periodic paralysis, acetazolamide sodium therapy was discontinued and replaced with fludrocortisone acetate therapy [4].

Psychiatry related information on Diacarb

• Following the oral administration of three 250-mg doses of acetazolamide sodium to nine patients with glaucomatous visual-field defects, a statistically significant improvement in the differential threshold was observed, whereas in 16 glaucoma suspects, no change could be detected [5].

High impact information on Diacarb

• Initial treatment was non-operative using nasogastric suction, diamox, atropine, and multiple paracenteses or thoracenteses [6].
• Although the limitation in vasodilative capacity under Diamox-activated conditions was underestimated using 99mTc-labeled CBF tracers as compared with [123I]IMP, a retention of 99mTc-ECD in the unaffected area with an increased CBF under Diamox activation could be relatively superior to 99mTc-HMPAO [7].
• The effect on outflow to general blood circulation and uveoscleral outflow were determined by using the fluorophotometric Diamox technique, and the effect on the uveoscleral outflow was further assessed by using the anterior chamber perfusion method [8].
• 4. Steady-state transepithelial pH differences were reduced in metabolic alkalosis and after diamox but augmented during metabolic acidosis [2].
• The binding of four inhibitors--mercuric ion, 3-acetoxymercuri-4-aminobenzenesulfonamide (AMS), acetazolamide (Diamox), and thiocyanate ion--to human carbonic anhydrase II (HCA II) has been studied with X-ray crystallography [9].

Chemical compound and disease context of Diacarb

• Nine patients with ocular hypertension each randomly received on separate days 0, 63, 125, 250, and 500 mg of acetazolamide (Diamox) [10].
• Status epilepticus of the absence type is managed with i.v. acetazolamide sodium or diazepam [11].

Biological context of Diacarb

• Diamox did not have an important effect on blood pressure, pulse rate, or respiratory rate [12].
• In both studies, intravenous Diamox caused a fall of intraocular pressure (IOP) within 30 min [13].
• The influences of 30% stable xenon/O2 mixture on somatosensory evoked potentials were investigated in 8 patients with and without Diamox application [14].
• Therefore, an assessment of cerebral autoregulation should consider not only responsiveness to CO2 or Diamox [15].

Anatomical context of Diacarb

• DIAMOX inhibited statoconia formation and/or prevented calcium and the matrix from associating [16].
• Intracellular pH (pHi) of the liver, heart, brain, and two skeletal muscle groups as calculated from the distribution of 14C-labelled DMO (5.5-dimethyl-2,4-oxazolidinedione) was compared to corresponding tissues of a control group and rats treated with the carbonic anhydrase inhibitor acetazolamide (Diamox) [17].
• Four cases corresponding each to the four subgroups were studied electrophysiologically by our new tests for the cone receptor cell (rapid off-response in the ERG) and for the retinal pigment epithelium (the hyperosmolarity response and the Diamox response) [18].
• Effect of acetazolamide (Diamox) on the endolymphatic sac [19].
• All six patients with thalamic diaschisis and five of eight patients with crossed cerebellar diaschisis at baseline showed significantly augmented perfusion after Diamox administration in the affected thalamus and cerebellum compared with that in the contralateral unaffected areas [20].

Associations of Diacarb with other chemical compounds

• Proximal intratubular free-flow pressure, measured by micropuncture, and internal proximal diameters were significantly increased above normal controls in all groups, but were least abnormal in the rats receiving HCO3- and diamox [21].
• Sodium hyaluronate left in the anterior chamber can cause an increase in intraocular pressure and prophylactic measures, such as diamox and timoptic should be used in these cases [22].

Gene context of Diacarb

• In a prospective study, 41 patients with documented chronic macular edema of various causes were entered into a therapeutic trial of acetazolamide sodium, a carbonic anhydrase inhibitor [23].
• The selective deterioration of the Diamox response in CECR, but not in ARMD, can serve as a new index for differentiating between these similar conditions [24].
• TCD and the Diamox test for testing vasomotor reactivity: clinical significance [25].
• Ammonia production by whole-kidney homogenates was decreased by Diamox, confirming the drug's action as inhibiting glutaminase activity [26].

Analytical, diagnostic and therapeutic context of Diacarb

• Assessment of postischemic reperfusion and diamox activation test in stroke using 99mTc-ECD SPECT [7].
• Prevention is predicated upon slow ascent to altitude and minimizing initial exertion at altitude; in selected cases, preventive drug therapy with Diamox (Lederle, Pearl River, New York) is helpful [27].
• In three eyes with a retained intraocular metallic foreign body, the neural retina and retinal pigment epithelial (RPE) integrity were evaluated by means of ERG (a-wave, b-wave, oscillatory potentials) and non-photic EOG responses from the RPE (hyperosmolarity response, Diamox response, bicarbonate response) [28].
• A second MRI was unchanged, and a lumbar puncture performed while the patient was taking Diamox was entirely normal [29].
• How brain SPECT scans conducted during Diamox initiated cerebrovascular stress tests can complement the information obtained from baseline studies and assist in the interpretation of r-CBF abnormalities is also demonstrated [30].

References