The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

Diamox     sodium(5-acetamido-1,3,4- thiadiazol-2...

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Diacarb


Psychiatry related information on Diacarb


High impact information on Diacarb


Chemical compound and disease context of Diacarb


Biological context of Diacarb


Anatomical context of Diacarb

  • DIAMOX inhibited statoconia formation and/or prevented calcium and the matrix from associating [16].
  • Intracellular pH (pHi) of the liver, heart, brain, and two skeletal muscle groups as calculated from the distribution of 14C-labelled DMO (5.5-dimethyl-2,4-oxazolidinedione) was compared to corresponding tissues of a control group and rats treated with the carbonic anhydrase inhibitor acetazolamide (Diamox) [17].
  • Four cases corresponding each to the four subgroups were studied electrophysiologically by our new tests for the cone receptor cell (rapid off-response in the ERG) and for the retinal pigment epithelium (the hyperosmolarity response and the Diamox response) [18].
  • Effect of acetazolamide (Diamox) on the endolymphatic sac [19].
  • All six patients with thalamic diaschisis and five of eight patients with crossed cerebellar diaschisis at baseline showed significantly augmented perfusion after Diamox administration in the affected thalamus and cerebellum compared with that in the contralateral unaffected areas [20].

Associations of Diacarb with other chemical compounds


Gene context of Diacarb

  • In a prospective study, 41 patients with documented chronic macular edema of various causes were entered into a therapeutic trial of acetazolamide sodium, a carbonic anhydrase inhibitor [23].
  • The selective deterioration of the Diamox response in CECR, but not in ARMD, can serve as a new index for differentiating between these similar conditions [24].
  • TCD and the Diamox test for testing vasomotor reactivity: clinical significance [25].
  • Ammonia production by whole-kidney homogenates was decreased by Diamox, confirming the drug's action as inhibiting glutaminase activity [26].

Analytical, diagnostic and therapeutic context of Diacarb

  • Assessment of postischemic reperfusion and diamox activation test in stroke using 99mTc-ECD SPECT [7].
  • Prevention is predicated upon slow ascent to altitude and minimizing initial exertion at altitude; in selected cases, preventive drug therapy with Diamox (Lederle, Pearl River, New York) is helpful [27].
  • In three eyes with a retained intraocular metallic foreign body, the neural retina and retinal pigment epithelial (RPE) integrity were evaluated by means of ERG (a-wave, b-wave, oscillatory potentials) and non-photic EOG responses from the RPE (hyperosmolarity response, Diamox response, bicarbonate response) [28].
  • A second MRI was unchanged, and a lumbar puncture performed while the patient was taking Diamox was entirely normal [29].
  • How brain SPECT scans conducted during Diamox initiated cerebrovascular stress tests can complement the information obtained from baseline studies and assist in the interpretation of r-CBF abnormalities is also demonstrated [30].


  1. Is impaired cerebral vasomotor reactivity a predictive factor of stroke in asymptomatic patients? Gur, A.Y., Bova, I., Bornstein, N.M. Stroke (1996) [Pubmed]
  2. Kinetics of luminal acidification in cortical tubules of the rat kidney. Giebisch, G., Malnic, G., De Mello, G.B., De Mello Aires, M. J. Physiol. (Lond.) (1977) [Pubmed]
  3. Abnormal cisternogram associated with Diamox therapy. Papanicolaou, N., McNeil, B.J., Funkenstein, H.H., Sudarsky, L.R. J. Nucl. Med. (1978) [Pubmed]
  4. Defective aldosterone synthesis associated with hyperkalemic periodic paralysis. Allen, D.B. Arch. Neurol. (1993) [Pubmed]
  5. Effect of acetazolamide on the differential threshold. Flammer, J., Drance, S.M. Arch. Ophthalmol. (1983) [Pubmed]
  6. Internal pancreatic fistulas: pancreatic ascites and pleural effusions. Cameron, J.L., Kieffer, R.S., Anderson, W.J., Zuidema, G.D. Ann. Surg. (1976) [Pubmed]
  7. Assessment of postischemic reperfusion and diamox activation test in stroke using 99mTc-ECD SPECT. Nakagawara, J., Nakamura, J., Takeda, R., Okumura, T., Seki, T., Hayase, K., Satoh, K., Suematsu, K. J. Cereb. Blood Flow Metab. (1994) [Pubmed]
  8. Effects of topical nipradilol, a beta-blocking agent with alpha-blocking and nitroglycerin-like activities, on aqueous humor dynamics and fundus circulation. Kanno, M., Araie, M., Tomita, K., Sawanobori, K. Invest. Ophthalmol. Vis. Sci. (1998) [Pubmed]
  9. Crystallographic studies of inhibitor binding sites in human carbonic anhydrase II: a pentacoordinated binding of the SCN- ion to the zinc at high pH. Eriksson, A.E., Kylsten, P.M., Jones, T.A., Liljas, A. Proteins (1988) [Pubmed]
  10. Short-term dose response characteristics of acetazolamide in man. Friedland, B.R., Mallonee, J., Anderson, D.R. Arch. Ophthalmol. (1977) [Pubmed]
  11. Drug therapy reviews: drug therapy of status epilepticus. Browne, T.R. American journal of hospital pharmacy. (1978) [Pubmed]
  12. The rCBF response to Diamox in normal subjects and cerebrovascular disease patients. Sullivan, H.G., Kingsbury, T.B., Morgan, M.E., Jeffcoat, R.D., Allison, J.D., Goode, J.J., McDonnell, D.E. J. Neurosurg. (1987) [Pubmed]
  13. A comparative study of Ocusert Pilo 40, intensive pilocarpine and low-dose pilocarpine in the initial treatment of primary acute angle-closure glaucoma. Edwards, R.S. Current medical research and opinion. (1997) [Pubmed]
  14. Effects of 33% stable xenon/O2 mixture on somatosensory evoked potentials. Lorenz, M., Holl, K., Nemati, N., Haubitz, B., Gaab, M.R., Dietz, H. Neurol. Res. (1991) [Pubmed]
  15. Multimodality monitoring during passive tilt and Valsalva maneuver under hypercapnia. Hetzel, A., Braune, S., Guschlbauer, B., Dohms, K., Prasse, A., Lücking, C.H. Journal of neuroimaging : official journal of the American Society of Neuroimaging. (1999) [Pubmed]
  16. Ultrastructural changes of statoconia after segmentation of the otolithic membrane. Fermin, C.D., Igarashi, M., Yoshihara, T. Hear. Res. (1987) [Pubmed]
  17. Correction of metabolic alkalosis by HCl and acetazolamide: effects on extracellular and intracellular acid-base status in rats in vivo. Rothe, K.F., Heisler, N. Acta anaesthesiologica Scandinavica. (1986) [Pubmed]
  18. Electrophysiological analysis of Stargardt's disease fundus flavimaculatus group. Wakabayashi, K., Yonemura, D., Kawasaki, K. Documenta ophthalmologica. Advances in ophthalmology. (1985) [Pubmed]
  19. Effect of acetazolamide (Diamox) on the endolymphatic sac. Takumida, M., Bagger-Sjöbäck, D., Rask-Andersen, H. ORL J. Otorhinolaryngol. Relat. Spec. (1989) [Pubmed]
  20. Acetazolamide effect on vascular response in areas with diaschisis as measured by Tc-99m HMPAO brain SPECT. Matsuda, H., Tsuji, S., Sumiya, H., Hogashi, S., Kinuya, K., Tonami, N., Hisada, K., Yamashita, J. Clinical nuclear medicine. (1992) [Pubmed]
  21. Effects of dietary electrolyte supplementation on gentamicin nephrotoxicity. Aynedjian, H.S., Nguyen, D., Lee, H.Y., Sablay, L.B., Bank, N. Am. J. Med. Sci. (1988) [Pubmed]
  22. Sodium hyaluronate (Healon) in the surgical repair of Descemet's membrane detachment. Donzis, P.B., Karcioglu, Z.A., Insler, M.S. Ophthalmic surgery. (1986) [Pubmed]
  23. Treatment of chronic macular edema with acetazolamide. Cox, S.N., Hay, E., Bird, A.C. Arch. Ophthalmol. (1988) [Pubmed]
  24. Differentiation of neovascular maculopathies by nonphotic electrooculogram responses. Shirao, Y., Ushimura, S., Kawasaki, K. Jpn. J. Ophthalmol. (1997) [Pubmed]
  25. TCD and the Diamox test for testing vasomotor reactivity: clinical significance. Gur, A.Y., Bornstein, N.M. Neurologia i neurochirurgia polska. (2001) [Pubmed]
  26. Renal glutaminases: Diamox inhibition of glutamyltransferase. Phenix, P., Welbourne, T.C. Am. J. Physiol. (1975) [Pubmed]
  27. High-altitude medical problems. Mountain, R.D. Clin. Orthop. Relat. Res. (1987) [Pubmed]
  28. Evaluation of retinal integrity in eyes with retained intraocular metallic foreign body by ERG and EOG. Tanabe, J., Shirao, Y., Oda, N., Kawasaki, K. Documenta ophthalmologica. Advances in ophthalmology. (1992) [Pubmed]
  29. Glioblastoma multiforme masquerading as pseudotumor cerebri. Case report. Aroichane, M., Miller, N.R., Eggenberger, E.R. Journal of clinical neuro-ophthalmology. (1993) [Pubmed]
  30. Regional cerebral blood flow changes in stroke imaged by Tc-99m HMPAO SPECT with corresponding anatomic image comparison. Mountz, J.M., Deutsch, G., Khan, S.H. Clinical nuclear medicine. (1993) [Pubmed]
WikiGenes - Universities