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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Ocular Hypotension

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Disease relevance of Ocular Hypotension

  • Thus the 1,11-lactone and 11,15-dipivaloyl ester prodrugs appeared to be superior to the others in providing bioavailable PGF2alpha for ocular hypotension, while minimizing hyperemia [1].
  • These injections resulted in uveitis characterized by prolonged ocular hypotony, increased protein concentrations and decreased ascorbic acid concentrations in both the vitreous and aqueous humors, and an apparent decrease in the transport function of the anterior uvea [2].
  • Although PGF2 alpha and, to a much lesser extent, PGE2 have a miotic effect in cats, PGs of the A and B type did not cause significant miosis even at doses 50- to 100-fold greater than the minimum dose required to yield significant ocular hypotension [3].
  • On the basis of our results, we believe that a causal relationship exists between the metabolic acidosis induced by acetazolamide, and by other drugs that have a blood-acidifying effect as the result of other mechanisms, and ocular hypotension, bothin the animal and in the glaucomatous patient [4].
  • However, because of the limited drug-induced ocular hypotension, brimonidine should be combined with other drugs when used for the glaucomas in the dog [5].

High impact information on Ocular Hypotension


Chemical compound and disease context of Ocular Hypotension


Anatomical context of Ocular Hypotension


Gene context of Ocular Hypotension


Analytical, diagnostic and therapeutic context of Ocular Hypotension


  1. Ocular penetration and bioconversion of prostaglandin F2alpha prodrugs in rabbit cornea and conjunctiva. Chien, D.S., Tang-Liu, D.D., Woodward, D.F. Journal of pharmaceutical sciences. (1997) [Pubmed]
  2. The pathophysiology of the ocular microenvironment. II. Copper-induced ocular inflammation and hypotony. McGahan, M.C., Bito, L.Z., Myers, B.M. Exp. Eye Res. (1986) [Pubmed]
  3. Eicosanoids as a new class of ocular hypotensive agents. 1. The apparent therapeutic advantages of derived prostaglandins of the A and B type as compared with primary prostaglandins of the E, F and D type. Bito, L.Z., Baroody, R.A., Miranda, O.C. Exp. Eye Res. (1987) [Pubmed]
  4. Acetazolamide, metabolic acidosis, and intraocular pressure. Bietti, G., Virno, M., Pecori-Giraldi, J. Am. J. Ophthalmol. (1975) [Pubmed]
  5. Effect of single and multiple doses of 0.2% brimonidine tartrate in the glaucomatous Beagle. Gelatt, K.N., MacKay, E.O. Veterinary ophthalmology. (2002) [Pubmed]
  6. Neuroprotection of retinal ganglion cells by brimonidine in rats with laser-induced chronic ocular hypertension. WoldeMussie, E., Ruiz, G., Wijono, M., Wheeler, L.A. Invest. Ophthalmol. Vis. Sci. (2001) [Pubmed]
  7. Isocapnia blocks exercise-induced reductions in ocular tension. Harris, A., Malinovsky, V.E., Cantor, L.B., Henderson, P.A., Martin, B.J. Invest. Ophthalmol. Vis. Sci. (1992) [Pubmed]
  8. Studies on the ocular pharmacology of prostaglandin D2. Woodward, D.F., Hawley, S.B., Williams, L.S., Ralston, T.R., Protzman, C.E., Spada, C.S., Nieves, A.L. Invest. Ophthalmol. Vis. Sci. (1990) [Pubmed]
  9. Ocular hypotension in the rabbit. Receptor mechanisms of pirbuterol and nylidrin. Mittag, T.W., Tormay, A., Messenger, M., Podos, S.M. Invest. Ophthalmol. Vis. Sci. (1985) [Pubmed]
  10. Mechanisms and sites of ocular action of 7-hydroxy-2-dipropylaminotetralin: a dopamine(3) receptor agonist. Chu, E., Chu, T.C., Potter, D.E. J. Pharmacol. Exp. Ther. (2000) [Pubmed]
  11. Pilocarpine antagonizes prostaglandin F2 alpha-induced ocular hypotension in monkeys. Evidence for enhancement of Uveoscleral outflow by prostaglandin F2 alpha. Crawford, K., Kaufman, P.L. Arch. Ophthalmol. (1987) [Pubmed]
  12. Isobutylmethylxanthine enhances adrenergic-induced ocular hypotension in rabbits and beagles. Hoyng, P.F., Groeneboer, M.C., Busch, M.J. Exp. Eye Res. (1991) [Pubmed]
  13. Effects of 2-alkynyladenosine derivatives on intraocular pressure in rabbits. Konno, T., Ohnuma, S.Y., Uemoto, K., Uchibori, T., Nagai, A., Kogi, K., Endo, K., Hosokawa, T., Nakahata, N. Eur. J. Pharmacol. (2004) [Pubmed]
  14. 8OH-DPAT-Induced ocular hypotension: sites and mechanisms of action. Chu, T.C., Ogidigben, M.J., Potter, D.E. Exp. Eye Res. (1999) [Pubmed]
  15. The central effects of moxonidine on intraocular pressure and its antagonism by L-659, 066 and L-657, 743 in the rabbit. Campbell, W.R., Potter, D.E. Prog. Neuropsychopharmacol. Biol. Psychiatry (1994) [Pubmed]
  16. Modulation of intraocular pressure by adenosine agonists. Crosson, C.E., Gray, T. Journal of ocular pharmacology. (1994) [Pubmed]
  17. Changes in refraction caused by induction of acute hyperglycemia in healthy volunteers. Furushima, M., Imaizumi, M., Nakatsuka, K. Jpn. J. Ophthalmol. (1999) [Pubmed]
  18. Iris atrophy, serous detachment of the ciliary body, and ocular hypotony in chronic phase of Vogt-Koyanagi-Harada disease. Saari, J.M., Nummelin, K. European journal of ophthalmology. (2005) [Pubmed]
  19. Biodegradable calcium phosphate nanoparticles as a new vehicle for delivery of a potential ocular hypotensive agent. Chu, T.C., He, Q., Potter, D.E. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics. (2002) [Pubmed]
  20. Topical ibopamine in the treatment of chronic ocular hypotony attributable to vitreoretinal surgery, uveitis, or penetrating trauma. Ugahary, L.C., Ganteris, E., Veckeneer, M., Cohen, A.C., Jansen, J., Mulder, P.G., van Meurs, J.C. Am. J. Ophthalmol. (2006) [Pubmed]
  21. Centrally mediated ocular hypotension: potential role of imidazoline receptors. Campbell, W.R., Potter, D.E. Ann. N. Y. Acad. Sci. (1995) [Pubmed]
  22. Possibility of isoproterenol therapy with soft contact lenses: ocular hypotension without systemic effects. Bietti, G., Virno, M., Pecori-giraldi, J., Pellegrino, N., Motolese, E. Annals of ophthalmology. (1976) [Pubmed]
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