Disease relevance of Dicaffeoylquinic acid

• Dicaffeoylquinic acid inhibitors of human immunodeficiency virus integrase: inhibition of the core catalytic domain of human immunodeficiency virus integrase [1].
• The effect of 1,5-dicaffeoylquinic acid (cynarine) on ethanol induced hypertriglyceridemia and on hepatic concentration of triglyceride was investigated [2].

High impact information on Dicaffeoylquinic acid

• Using AFTIR, we identified Cynarin in Echinacea purpurea by its selective binding to chip immobilized CD28, a receptor of T-cells, which is instrumental to immune functioning [3].
• The results of surface plasma resonance show that binding between immobilized CD28 and Cynarin is stronger than the binding between CD28 and CD80, a co-stimulated receptor of antigen presenting cells [3].
• Seventeen ambulant outpatients with familial Type IIa or Type IIb hyperlipoproteinaemia were treated with Cynarin, the 1,5-dicaffeyl ester of quinic acid, the constituent of the artichoke (Cynara scolymus) [4].
• ECHINACEA plants grown in the controlled environment systems had higher or similar amounts of cynarin, caftaric acid, echinacoside and cichoric acid as previously reported in the literature for both field-cultivated and wild-harvested ECHINACEA plants [5].
• At 0.05 and 0.5 microM doxorubicin concentration, cynarine increased HeLa cell growth by 48-125% and 29-101%, respectively (p<0.01) [6].

Biological context of Dicaffeoylquinic acid

• Among these caffeoyl conjugates, chicoric and caftaric acids had the greatest antihyaluronidase activity: IC50 = 0.42 and 0.61 mM, while the IC50 of cynarine and chlorogenic acid were 1.85 and 2.25 mM [7].

Anatomical context of Dicaffeoylquinic acid

• Cynarine showed proliferative activity on HeLa cells, but showed antiproliferative activity on MCF-7 cells [6].

Associations of Dicaffeoylquinic acid with other chemical compounds

• Various potential pharmacodynamic effects have been observed in vitro for mono- and dicaffeoylquinic acids (e.g. chlorogenic acid, cynarin), caffeic acid and flavonoids (e.g. luteolin-7-O-glucoside) which are the main phenolic constituents of artichoke leaf extract (ALE) [8].
• In our opinion reported positive results with EPL, PP and cynarin are partially due to the methods of administration, selection of inpatients and dietary influences [9].

Analytical, diagnostic and therapeutic context of Dicaffeoylquinic acid

• Cynara scolymus leaves extracts have long been used in folk medicine for their choleretic and hepatoprotective activities, that are often related to the cynarin content [10].

References