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Chemical Compound Review

Cynarine     (1R,3R,4S,5R)-1,3-bis[[(E)-3- (3,4...

Synonyms: Phemocil, Cinarin, Cynarin, Cynarine [INN], SureCN42528, ...
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Disease relevance of Dicaffeoylquinic acid


High impact information on Dicaffeoylquinic acid


Biological context of Dicaffeoylquinic acid

  • Among these caffeoyl conjugates, chicoric and caftaric acids had the greatest antihyaluronidase activity: IC50 = 0.42 and 0.61 mM, while the IC50 of cynarine and chlorogenic acid were 1.85 and 2.25 mM [7].

Anatomical context of Dicaffeoylquinic acid

  • Cynarine showed proliferative activity on HeLa cells, but showed antiproliferative activity on MCF-7 cells [6].

Associations of Dicaffeoylquinic acid with other chemical compounds

  • Various potential pharmacodynamic effects have been observed in vitro for mono- and dicaffeoylquinic acids (e.g. chlorogenic acid, cynarin), caffeic acid and flavonoids (e.g. luteolin-7-O-glucoside) which are the main phenolic constituents of artichoke leaf extract (ALE) [8].
  • In our opinion reported positive results with EPL, PP and cynarin are partially due to the methods of administration, selection of inpatients and dietary influences [9].

Analytical, diagnostic and therapeutic context of Dicaffeoylquinic acid


  1. Dicaffeoylquinic acid inhibitors of human immunodeficiency virus integrase: inhibition of the core catalytic domain of human immunodeficiency virus integrase. Robinson, W.E., Cordeiro, M., Abdel-Malek, S., Jia, Q., Chow, S.A., Reinecke, M.G., Mitchell, W.M. Mol. Pharmacol. (1996) [Pubmed]
  2. Effect of 1,5-dicaffeoylquinic acid on ethanol-induced hypertriglyceridemia. Short communication. Wójcicki, J. Arzneimittel-Forschung. (1976) [Pubmed]
  3. Immuno-suppressive effect of blocking the CD28 signaling pathway in T-cells by an active component of Echinacea found by a novel pharmaceutical screening method. Dong, G.C., Chuang, P.H., Forrest, M.D., Lin, Y.C., Chen, H.M. J. Med. Chem. (2006) [Pubmed]
  4. Inefficiency of cynarin as therapeutic regimen in familial type II hyperlipoproteinaemia. Heckers, H., Dittmar, K., Schmahl, F.W., Huth, K. Atherosclerosis (1977) [Pubmed]
  5. Growing Environment and Nutrient Availability Affect the Content of Some Phenolic Compounds in Echinacea purpurea and Echinacea angustifolia. Zheng, Y., Dixon, M., Saxena, P.K. Planta Med. (2006) [Pubmed]
  6. Proliferative activity of Echinacea angustifolia root extracts on cancer cells: interference with doxorubicin cytotoxicity. Huntimer, E.D., Halaweish, F.T., Chase, C.C. Chem. Biodivers. (2006) [Pubmed]
  7. Direct characterization of caffeoyl esters with antihyaluronidase activity in crude extracts from Echinacea angustifolia roots by fast atom bombardment tandem mass spectrometry. Facino, R.M., Carini, M., Aldini, G., Marinello, C., Arlandini, E., Franzoi, L., Colombo, M., Pietta, P., Mauri, P. Farmaco (1993) [Pubmed]
  8. Bioavailability and pharmacokinetics of caffeoylquinic acids and flavonoids after oral administration of Artichoke leaf extracts in humans. Wittemer, S.M., Ploch, M., Windeck, T., Müller, S.C., Drewelow, B., Derendorf, H., Veit, M. Phytomedicine (2005) [Pubmed]
  9. Frequently used lipid-lowering drugs having no guaranteed effect. Scheffler, W., Schwartzkopff, W. Artery (1980) [Pubmed]
  10. Efficacy of different Cynara scolymus preparations on liver complaints. Speroni, E., Cervellati, R., Govoni, P., Guizzardi, S., Renzulli, C., Guerra, M.C. Journal of ethnopharmacology. (2003) [Pubmed]
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