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Chemical Compound Review

AC1L9DEQ     [(2R,3R,4R,5R,6R)-6-[2-(3,4...

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Disease relevance of C10450


High impact information on C10450

  • In contrast, Echinacea extracts chemically standardized to phenolic acid or echinacoside content and fresh pressed juice preparations were found to be inactive as immunostimulatory agents but did display, to varying degrees, anti-inflammatory and antioxidant properties [3].
  • ECHINACEA plants grown in the controlled environment systems had higher or similar amounts of cynarin, caftaric acid, echinacoside and cichoric acid as previously reported in the literature for both field-cultivated and wild-harvested ECHINACEA plants [4].
  • Echinacoside rescues the SHSY5Y neuronal cells from TNFalpha-induced apoptosis [1].
  • The antiapoptotic action of echinacoside was partially dependent on antioxidative stress effects, maintenance of mitochondria function, inhibition of caspase-3 activity and was also associated with increasing the expression of the antiapoptotic protein Bcl2 [1].
  • Rapid and non-destructive determination of the echinacoside content in Echinacea roots by ATR-IR and NIR spectroscopy [5].

Biological context of C10450


Associations of C10450 with other chemical compounds


Analytical, diagnostic and therapeutic context of C10450

  • In contrast to the time-consuming HPLC method, the described non-destructive measurements allow us to predict the echinacoside content already after an analysis time of approx. one minute [5].
  • The SDS-PAGE pattern of native collagen is markedly modified by free radical attack, with formation of a great number of peptide fragments with molecular masses below 97 kDa: in the presence of microM concentrations of echinacoside, there is a complete recovery of the native profile [9].


  1. Echinacoside rescues the SHSY5Y neuronal cells from TNFalpha-induced apoptosis. Deng, M., Zhao, J.Y., Tu, P.F., Jiang, Y., Li, Z.B., Wang, Y.H. Eur. J. Pharmacol. (2004) [Pubmed]
  2. Protection of phenylpropanoid glycosides from Pedicularis against oxidative hemolysis in vitro. Li, J., Wang, P.F., Zheng, R., Liu, Z.M., Jia, Z. Planta Med. (1993) [Pubmed]
  3. Immunopharmacological activity of Echinacea preparations following simulated digestion on murine macrophages and human peripheral blood mononuclear cells. Rininger, J.A., Kickner, S., Chigurupati, P., McLean, A., Franck, Z. J. Leukoc. Biol. (2000) [Pubmed]
  4. Growing Environment and Nutrient Availability Affect the Content of Some Phenolic Compounds in Echinacea purpurea and Echinacea angustifolia. Zheng, Y., Dixon, M., Saxena, P.K. Planta Med. (2006) [Pubmed]
  5. Rapid and non-destructive determination of the echinacoside content in Echinacea roots by ATR-IR and NIR spectroscopy. Schulz, H., Pfeffer, S., Quilitzsch, R., Steuer, B., Reif, K. Planta Med. (2002) [Pubmed]
  6. Hydrolysis and redox factors affecting analysis of common phenolic marker compounds in botanical extracts and finished products. Baugh, S., Ignelzi, S. Journal of AOAC International. (2000) [Pubmed]
  7. Anti-inflammatory and cicatrizing activity of Echinacea pallida Nutt. root extract. Speroni, E., Govoni, P., Guizzardi, S., Renzulli, C., Guerra, M.C. Journal of ethnopharmacology. (2002) [Pubmed]
  8. Determination of echinacoside in rat serum by reversed-phase high-performance liquid chromatography with ultraviolet detection and its application to pharmacokinetics and bioavailability. Jia, C., Shi, H., Wu, X., Li, Y., Chen, J., Tu, P. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. (2006) [Pubmed]
  9. Echinacoside and caffeoyl conjugates protect collagen from free radical-induced degradation: a potential use of Echinacea extracts in the prevention of skin photodamage. Facino, R.M., Carini, M., Aldini, G., Saibene, L., Pietta, P., Mauri, P. Planta Med. (1995) [Pubmed]
  10. Synergistic antioxidative effects of alkamides, caffeic acid derivatives, and polysaccharide fractions from Echinacea purpurea on in vitro oxidation of human low-density lipoproteins. Dalby-Brown, L., Barsett, H., Landbo, A.K., Meyer, A.S., Mølgaard, P. J. Agric. Food Chem. (2005) [Pubmed]
  11. Evaluation of antioxidant activity of some natural polyphenolic compounds using the Briggs-Rauscher reaction method. Cervellati, R., Renzulli, C., Guerra, M.C., Speroni, E. J. Agric. Food Chem. (2002) [Pubmed]
  12. In vitro and in vivo immune stimulating effects of a new standardized Echinacea angustifolia root extract (Polinacea). Morazzoni, P., Cristoni, A., Di Pierro, F., Avanzini, C., Ravarino, D., Stornello, S., Zucca, M., Musso, T. Fitoterapia (2005) [Pubmed]
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