Chemical Compound Review:
AIDS-166861 1-(3,4-dichlorophenyl)-2-(N'- propan-2...
Synonyms:
Winstanley,
Watkins,
Muhia,
Szwandt,
Amukoye,
Marsh,
Simpson,
Hughes,
Manyando,
Bojang,
Aarons,
Winstanley,
Edwards,
Watkins,
Ward,
Brabin,
Eggelte,
Parise,
Verhoeff,
Alker,
Mwapasa,
Purfield,
Rogerson,
Molyneux,
Kamwendo,
Tadesse,
Chaluluka,
Meshnick,
Nzila,
Nduati,
Mberu,
Hopkins Sibley,
Monks,
Winstanley,
Watkins,
- Chlorproguanil chemoprophylaxis for falciparum malaria in Kenya. O'Neil, A.B., Law, B., Haworth, S.J., Tuersley, L.V. Lancet (1987)
- Inadequacy of chlorproguanil 20 mg per week as chemoprophylaxis for falciparum malaria in Kenya. Watkins, W.M., Brandling-Bennett, A.D., Oloo, A.J., Howells, R.E., Gilles, H.M., Koech, D.K. Lancet (1987)
- Molecular evidence of greater selective pressure for drug resistance exerted by the long-acting antifolate Pyrimethamine/Sulfadoxine compared with the shorter-acting chlorproguanil/dapsone on Kenyan Plasmodium falciparum. Nzila, A.M., Nduati, E., Mberu, E.K., Hopkins Sibley, C., Monks, S.A., Winstanley, P.A., Watkins, W.M. J. Infect. Dis. (2000)
- Dapsone therapy for malaria during pregnancy: maternal and fetal outcomes. Brabin, B.J., Eggelte, T.A., Parise, M., Verhoeff, F. Drug safety : an international journal of medical toxicology and drug experience. (2004)
- In vitro metabolism of the biguanide antimalarials in human liver microsomes: evidence for a role of the mephenytoin hydroxylase (P450 MP) enzyme. Helsby, N.A., Ward, S.A., Howells, R.E., Breckenridge, A.M. British journal of clinical pharmacology. (1990)
- Chlorproguanil/dapsone for uncomplicated Plasmodium falciparum malaria in young children: pharmacokinetics and therapeutic range. Winstanley, P., Watkins, W., Muhia, D., Szwandt, S., Amukoye, E., Marsh, K. Trans. R. Soc. Trop. Med. Hyg. (1997)
- Poor efficacy of antimalarial biguanide-dapsone combinations in the treatment of acute, uncomplicated, falciparum malaria in Thailand. Wilairatana, P., Kyle, D.E., Looareesuwan, S., Chinwongprom, K., Amradee, S., White, N.J., Watkins, W.M. Ann. Trop. Med. Parasitol. (1997)
- Pharmacokinetics of chlorproguanil in man after a single oral dose of Lapudrine. Veenendaal, J.R., Edstein, M.D., Rieckmann, K.H. Chemotherapy. (1988)
- Activity of dihydrofolate reductase inhibitors on the hepatic stages of Plasmodium yoelii yoelii in vitro. Eriksson, B., Courtier, B., Bjŏrkman, A., Miltgen, F., Mazier, D. Trans. R. Soc. Trop. Med. Hyg. (1991)
- Plasma, erythrocyte and urine concentrations of chlorproguanil and two metabolites in man after different doses. Petersen, E., Flachs, H., Høgh, B., Hanson, A.P., Björkman, A., Hvidberg, E.F. The Journal of tropical medicine and hygiene. (1991)
- In vitro sensitivity of Plasmodium falciparum to chlorcycloguanil in The Gambia. Panton, L.J., Greenwood, B.M. Trans. R. Soc. Trop. Med. Hyg. (1985)
- Double-blind study to assess the efficacy of chlorproguanil given alone or in combination with chloroquine for malaria chemoprophylaxis in an area with Plasmodium falciparum resistance to chloroquine, pyrimethamine and cycloguanil. Coosemans, M.H., Barutwanayo, M., Onori, E., Otoul, C., Gryseels, B., Wéry, M. Trans. R. Soc. Trop. Med. Hyg. (1987)
- Mutations associated with sulfadoxine-pyrimethamine and chlorproguanil resistance in Plasmodium falciparum isolates from Blantyre, Malawi. Alker, A.P., Mwapasa, V., Purfield, A., Rogerson, S.J., Molyneux, M.E., Kamwendo, D.D., Tadesse, E., Chaluluka, E., Meshnick, S.R. Antimicrob. Agents Chemother. (2005)
- Population pharmacokinetic and pharmacodynamic modelling of the antimalarial chemotherapy chlorproguanil/dapsone. Simpson, J.A., Hughes, D., Manyando, C., Bojang, K., Aarons, L., Winstanley, P., Edwards, G., Watkins, W.A., Ward, S. British journal of clinical pharmacology. (2006)