Disease relevance of Genitalia, Male

• PURPOSE: Congenital lymphedema is a rare disorder that may result in disfiguring edema of the male genitalia [1].
• Female pseudohermaphroditism with caudal dysplasia is a clinical entity in which normal-appearing male genitalia may occur in the apparent absence of testosterone or the sex-determining gene (SR Y) [2].
• CONCLUSIONS: Since oestrogen can modify certain androgen effects within cells and since formation of the male genitalia during embryogenesis is mediated by androgens, elevated oestrogen formation in male genital tissue might be a causative factor of hypospadias in some instances [3].
• Contact dermatitis of the male genitalia due to latex gloves [4].

Psychiatry related information on Genitalia, Male

• This proliferative phase, which begins on embryonic day 17 (E17), is induced by the interaction of a few specific neurons in the sex ganglia with a peripheral target, the male genitalia, during a critical period that extends from E13 to E16 [5].

High impact information on Genitalia, Male

• In the absence of cad function, the analia develop like the immediately anterior segment (male genitalia), following the transformation rule of the canonical Hox genes [6].
• Lipocalin-type prostaglandin D synthase (L-PGDS) is localized in the central nervous system and male genital organs of various mammals and is secreted as beta-trace into the closed compartment of these tissues separated from the systemic circulation [7].
• Lipocalin-type PGD synthase is localized in the central nervous system and male genital organs of various mammals and the human heart and is secreted into cerebrospinal fluid, seminal plasma, and plasma, respectively [8].
• Autonomous expression of Met was found both in abdominal cuticle as well as in external male genitalia [9].
• These results show that mPGES-1 is expressed coordinately with COX-1 and COX-2 and is involved in PGE(2) production in male genital organs [10].

Biological context of Genitalia, Male

• The retention of Müllerian structures and undervirilization of male genitalia in these cases could be the result of failure in production of adequate amounts of testosterone and Müllerian inhibitory factor at appropriate times in gestation [11].

Anatomical context of Genitalia, Male

• OBJECTIVE: The regulation of the androgen receptor (AR) and 5 alpha-reductase II (5RII) gene in genital skin fibroblasts is of particular interest in understanding androgen-dependent embryonic formation of external male genitalia [12].
• Once a testis is formed (the female sex being constitutive in nature), differentiation of the internal and external male genitalia is androgen dependent [13].
• Antimullerian hormone (AMH) secreted by Sertoli cells inhibits the development of female internal genitalia (tube, uterus, upper part of vagina); testosterone secreted by Leydig cells induces stabilization of wolffian ducts and development of internal male genitalia [14].

Associations of Genitalia, Male with chemical compounds

• One substrate for this membrane-bound enzyme is testosterone, whose reduction to dihydrotestosterone is required for the embryonic differentiation of the external male genitalia and prostate [15].
• Normal development of male genitalia in mammals depends on androgen action [16].
• Effect of prenatal estrogen exposure on male genitalia [17].
• The enzyme steroid 5alpha-reductase 2 (encoded by the SRD5A2 gene) catalyses the conversion of testosterone to dihydrotestosterone, which is required for normal differentiation of the external male genitalia [18].
• Although early flutamide prevented complete masculinization of male genitalia, this treatment was not accompanied by any alterations in the masculine pattern of infant interest [19].

Gene context of Genitalia, Male

• This deletion led us to refine the critical region of CXorf6 for the development of male genitalia [20].
• One example is mab-23, in a race from Vancouver, which leads to severe distortion of male genitalia and prevents male mating [21].
• These results suggest that BDNF is expressed in the internal male genital organs of the rat and that its expression is downregulated by androgen hormones [22].
• The enzyme steroid 5 alpha-reductase, via NADPH, catalyses the conversion of testosterone to dihydrotestosterone, which is required for the embryonic differentiation of the external male genitalia and the prostate [23].
• The fetal population appears during fetal life and is responsible for the androgen-induced differentiation of the male genitalia [24].

Analytical, diagnostic and therapeutic context of Genitalia, Male

• Physical examination. Part 14. Male genitalia [25].

References