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Chemical Compound Review

NSC371716     (3Z,6Z)-3,6-bis[(1,5- dimethyl-3-oxo-2...

Synonyms:
 
 
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High impact information on NSC371716

  • The impermeant dye antipyrylazo III was used to measure depletion of extracellular calcium and net influx of calcium through the sarcolemma during the cardiac action potential [1].
  • Sarcolemmal Ca2+ movements in frog ventricular strips were measured by monitoring Ca2+ depletion from the extracellular space with an impermeant Ca indicator dye, antipyrylazo III [2].
  • We have used a spectrophotometric method to monitor mean free extracellular calcium concentrations in isolated left atria of guinea pigs via extracellular application of the calcium-sensitive absorption dyes, antipyrylazo III and tetramethylmurexide [3].
  • Null point titration techniques have been developed for measurements of cytosolic free Mg2+ in isolated cells and matrix free Mg2+ in isolated mitochondria using antipyrylazo III as a spectrophotometric Mg2+ indicator [4].
  • Detergent incorporation affected neither the calcium-dependent phosphorylation from ATP, as judged from multimixer quenching experiments, nor the calcium-releasing transition between the two phosphoenzyme forms (Ca2E1P to E2P), as judged from kinetically resolved dual-wavelength measurements with the calcium-sensitive dye antipyrylazo III [5].
 

Biological context of NSC371716

  • Cells were loaded with 10 pl doses of the Ca2+ buffer antipyrylazo III (ApIII) at specific times in the cell cycle to attempt a competitive inhibition of Ca2+-dependent steps in NEB and initiation of mitosis [6].
  • For antipyrylazo III, the relaxation rate is much faster, less than 1 ms, and the complexing kinetics can be covered with only a CaAp complex [7].
  • The stoichiometry of the interactions of antipyrylazo III with Ca2+, Mg2+, Ba2+, Sr2+ and Zn2+ ions and the relevant binding constants were studied by principal component analysis (PCA) of the absorption spectral changes [8].
 

Anatomical context of NSC371716

 

Associations of NSC371716 with other chemical compounds

References

  1. Optical measurements of extracellular calcium depletion during a single heartbeat. Cleemann, L., Pizarro, G., Morad, M. Science (1984) [Pubmed]
  2. Optical measurement of voltage-dependent Ca2+ influx in frog heart. Pizarro, G., Cleemann, L., Morad, M. Proc. Natl. Acad. Sci. U.S.A. (1985) [Pubmed]
  3. Activation-dependent cumulative depletions of extracellular free calcium in guinea pig atrium measured with antipyrylazo III and tetramethylmurexide. Hilgemann, D.W., Delay, M.J., Langer, G.A. Circ. Res. (1983) [Pubmed]
  4. Regulation of free and bound magnesium in rat hepatocytes and isolated mitochondria. Corkey, B.E., Duszynski, J., Rich, T.L., Matschinsky, B., Williamson, J.R. J. Biol. Chem. (1986) [Pubmed]
  5. Kinetic characterization of the normal and detergent-perturbed reaction cycles of the sarcoplasmic reticulum calcium pump. Rate-limiting step(s) under different conditions. Champeil, P., le Maire, M., Andersen, J.P., Guillain, F., Gingold, M., Lund, S., Møller, J.V. J. Biol. Chem. (1986) [Pubmed]
  6. Nuclear envelope breakdown and mitosis in sand dollar embryos is inhibited by microinjection of calcium buffers in a calcium-reversible fashion, and by antagonists of intracellular Ca2+ channels. Silver, R.B. Dev. Biol. (1989) [Pubmed]
  7. Kinetics and mechanism of Ca2+ binding to arsenazo III and antipyrylazo III. Dorogi, P.L. Biochim. Biophys. Acta (1984) [Pubmed]
  8. Principal component analysis of the absorption and resonance Raman spectra of the metallochromic indicator antipyrylazo III. Pevzner, E., Ehrenberg, B. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. (2000) [Pubmed]
  9. Inactivation of a Ca2+-induced Ca2+ release channel from skeletal muscle sarcoplasmic reticulum during active Ca2+ transport. Morii, H., Takisawa, H., Yamamoto, T. J. Biol. Chem. (1985) [Pubmed]
  10. Magnesium permeability of sarcoplasmic reticulum. Mg2+ is not countertransported during ATP-dependent Ca2+ uptake by sarcoplasmic reticulum. Salama, G., Scarpa, A. J. Biol. Chem. (1985) [Pubmed]
  11. Generation of free radical metabolites and superoxide anion by the calcium indicators arsenazo III, antipyrylazo III, and murexide in rat liver microsomes. Docampo, R., Moreno, S.N., Mason, R.P. J. Biol. Chem. (1983) [Pubmed]
  12. Physiological role and selectivity of the in situ potassium channel of the sarcoplasmic reticulum in skinned frog skeletal muscle fibers. Abramcheck, C.W., Best, P.M. J. Gen. Physiol. (1989) [Pubmed]
  13. Calcium signals recorded from cut frog twitch fibers containing antipyrylazo III. Maylie, J., Irving, M., Sizto, N.L., Chandler, W.K. J. Gen. Physiol. (1987) [Pubmed]
  14. Arsenazo III and antipyrylazo III calcium transients in single skeletal muscle fibers. Palade, P., Vergara, J. J. Gen. Physiol. (1982) [Pubmed]
  15. Perchlorate and the relationship between charge movement and contractile activation in frog skeletal muscle fibres. Csernoch, L., Kovács, L., Szücs, G. J. Physiol. (Lond.) (1987) [Pubmed]
  16. Caffeine potentiation of calcium release in frog skeletal muscle fibres. Delay, M., Ribalet, B., Vergara, J. J. Physiol. (Lond.) (1986) [Pubmed]
  17. Pathways of calcium release from heavy sarcoplasmic reticulum vesicles isolated from rabbit skeletal muscle. Rubtsov, A.M., Quinn, P.J., Boldyrev, A.A. FEBS Lett. (1988) [Pubmed]
  18. Inositol 1,4,5-trisphosphate-induced calcium release from canine aortic sarcoplasmic reticulum vesicles. Watras, J., Benevolensky, D. Biochim. Biophys. Acta (1987) [Pubmed]
 
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