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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Principal Component Analysis

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Disease relevance of Principal Component Analysis


Psychiatry related information on Principal Component Analysis

  • A principal component analysis identified three interpretable factors: Emotional/Cognitive Concern for Dieting, Calorie Knowledge, Behavioral Dieting Control. Only Emotional/Cognitive Concern for Dieting equated with RS as both measures correlated with self-esteem and restrained drinking [3].

High impact information on Principal Component Analysis


Biological context of Principal Component Analysis


Anatomical context of Principal Component Analysis


Associations of Principal Component Analysis with chemical compounds


Gene context of Principal Component Analysis

  • Moreover, principal component analysis on ranks evidenced a poor association between TSP-1 and -2, VEGF and TP [21].
  • Guided by principal component analysis, we instead discovered that the most efficient bacterial selenoprotein production conditions were obtained with the high-transcription T7lac-driven pET vector system in presence of the selA, selB, and selC genes, with induction of production at late exponential phase [22].
  • Principal component analysis using KIR gene data from 20 populations was performed to determine genetic differences and relations between populations [23].
  • The relationships between age, sex, tumor size, GH and PRL plasma levels, granularity, and percentage of GH-, alpha SU-, and PRL-immunoreactive cells were established in 105 acromegalic patients by three statistical methods, mainly by a principal component analysis [24].
  • The principal component analysis of gene frequencies at HP, GC and PI loci shows two groups in the Basque Country: one comprising the indigenous inhabitants and those of mixed descent, the other of immigrants [25].

Analytical, diagnostic and therapeutic context of Principal Component Analysis


  1. Nasal biomarker profiles in acute and chronic rhinosinusitis. Riechelmann, H., Deutschle, T., Rozsasi, A., Keck, T., Polzehl, D., Bürner, H. Clin. Exp. Allergy (2005) [Pubmed]
  2. Genetics of colitis susceptibility in IL-10-deficient mice: backcross versus F2 results contrasted by principal component analysis. Mähler, M., Most, C., Schmidtke, S., Sundberg, J.P., Li, R., Hedrich, H.J., Churchill, G.A. Genomics (2002) [Pubmed]
  3. A two-factor model of dietary restraint. Ricciardelli, L.A., Williams, R.J. Journal of clinical psychology. (1997) [Pubmed]
  4. Molecular signatures in childhood acute leukemia and their correlations to expression patterns in normal hematopoietic subpopulations. Andersson, A., Olofsson, T., Lindgren, D., Nilsson, B., Ritz, C., Edén, P., Lassen, C., Råde, J., Fontes, M., Mörse, H., Heldrup, J., Behrendtz, M., Mitelman, F., Höglund, M., Johansson, B., Fioretos, T. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  5. Mapping of ventricular repolarization potentials in patients with arrhythmogenic right ventricular dysplasia: principal component analysis of the ST-T waves. De Ambroggi, L., Aimè, E., Ceriotti, C., Rovida, M., Negroni, S. Circulation (1997) [Pubmed]
  6. Comparative effect of atypical and conventional antipsychotic drugs on neurocognition in first-episode psychosis: a randomized, double-blind trial of olanzapine versus low doses of haloperidol. Keefe, R.S., Seidman, L.J., Christensen, B.K., Hamer, R.M., Sharma, T., Sitskoorn, M.M., Lewine, R.R., Yurgelun-Todd, D.A., Gur, R.C., Tohen, M., Tollefson, G.D., Sanger, T.M., Lieberman, J.A. The American journal of psychiatry. (2004) [Pubmed]
  7. Increases in regional subarachnoid CSF without apparent cortical gray matter deficits in schizophrenia: modulating effects of sex and age. Narr, K.L., Sharma, T., Woods, R.P., Thompson, P.M., Sowell, E.R., Rex, D., Kim, S., Asuncion, D., Jang, S., Mazziotta, J., Toga, A.W. The American journal of psychiatry. (2003) [Pubmed]
  8. Structure of selenocysteine synthase from Escherichia coli and location of tRNA in the seryl-tRNA(sec)-enzyme complex. Engelhardt, H., Forchhammer, K., Müller, S., Goldie, K.N., Böck, A. Mol. Microbiol. (1992) [Pubmed]
  9. Molecular phenotyping of human endometrium distinguishes menstrual cycle phases and underlying biological processes in normo-ovulatory women. Talbi, S., Hamilton, A.E., Vo, K.C., Tulac, S., Overgaard, M.T., Dosiou, C., Le Shay, N., Nezhat, C.N., Kempson, R., Lessey, B.A., Nayak, N.R., Giudice, L.C. Endocrinology (2006) [Pubmed]
  10. The use of principal component analysis to resolve the spectra and kinetics of cytochrome c oxidase reduction by 5,10-dihydro-5-methyl phenazine. Halaka, F.G., Babcock, G.T., Dye, J.L. Biophys. J. (1985) [Pubmed]
  11. HLA-DRB1 and HLA-DQB1 polymorphisms in Pacific Islands populations. Velickovic, Z.M., Delahunt, B., Carter, J.M. Tissue Antigens (2002) [Pubmed]
  12. Exploratory factor analysis of obsessive-compulsive patients and association with 5-HTTLPR polymorphism. Cavallini, M.C., Di Bella, D., Siliprandi, F., Malchiodi, F., Bellodi, L. Am. J. Med. Genet. (2002) [Pubmed]
  13. QSAR's based on partial order ranking. Carlsen, L., Sørensen, P.B., Thomsen, M., Brüggemann, R. SAR and QSAR in environmental research. (2002) [Pubmed]
  14. Reorganized cerebral metabolic interactions in temporal lobe epilepsy. Azari, N.P., Knorr, U., Arnold, S., Antke, C., Ebner, A., Niemann, H., Pettigrew, K.D., Witte, O.W., Seitz, R.J. Neuropsychologia. (1999) [Pubmed]
  15. Proteomic study of human hepatocellular carcinoma using two-dimensional difference gel electrophoresis with saturation cysteine dye. Fujii, K., Kondo, T., Yokoo, H., Yamada, T., Iwatsuki, K., Hirohashi, S. Proteomics (2005) [Pubmed]
  16. Essential dynamics of reversible peptide folding: memory-free conformational dynamics governed by internal hydrogen bonds. de Groot, B.L., Daura, X., Mark, A.E., Grubmüller, H. J. Mol. Biol. (2001) [Pubmed]
  17. Decreased serum 1,5-anhydroglucitol in nondiabetic subjects with a family history of NIDDM. Tsukui, S., Fukumura, Y., Kobayashi, I. Diabetes Care (1996) [Pubmed]
  18. Molecular alterations in primary prostate cancer after androgen ablation therapy. Best, C.J., Gillespie, J.W., Yi, Y., Chandramouli, G.V., Perlmutter, M.A., Gathright, Y., Erickson, H.S., Georgevich, L., Tangrea, M.A., Duray, P.H., González, S., Velasco, A., Linehan, W.M., Matusik, R.J., Price, D.K., Figg, W.D., Emmert-Buck, M.R., Chuaqui, R.F. Clin. Cancer Res. (2005) [Pubmed]
  19. Metabonomics and biomarker discovery: LC-MS metabolic profiling and constant neutral loss scanning combined with multivariate data analysis for mercapturic acid analysis. Wagner, S., Scholz, K., Donegan, M., Burton, L., Wingate, J., Völkel, W. Anal. Chem. (2006) [Pubmed]
  20. Decomposition of pharmacological activity indices into mutually independent components using principal component analysis. Lukovits, I., Lopata, A. J. Med. Chem. (1980) [Pubmed]
  21. Thrombospondin-1 and -2 in node-negative breast cancer: correlation with angiogenic factors, p53, cathepsin D, hormone receptors and prognosis. Gasparini, G., Toi, M., Biganzoli, E., Dittadi, R., Fanelli, M., Morabito, A., Boracchi, P., Gion, M. Oncology (2001) [Pubmed]
  22. Assessment of production conditions for efficient use of Escherichia coli in high-yield heterologous recombinant selenoprotein synthesis. Rengby, O., Johansson, L., Carlson, L.A., Serini, E., Vlamis-Gardikas, A., Kårsnäs, P., Arnér, E.S. Appl. Environ. Microbiol. (2004) [Pubmed]
  23. Distribution of killer-cell immunoglobulin-like receptor (KIR) in Comoros and Southeast France. Frassati, C., Touinssi, M., Picard, C., Segura, M., Galicher, V., Papa, K., Gagne, K., Vivier, E., Degioanni, A., Böetsch, G., Mercier, P., Vély, F., de Micco, P., Reviron, D., Chiaroni, J. Tissue Antigens (2006) [Pubmed]
  24. Relationships between pathological diagnosis and clinical parameters in acromegaly. Trouillas, J., Sassolas, G., Guigard, M.P., Fonlupt, P., Ansaneli-Naves, L., Perrin, G. Metab. Clin. Exp. (1996) [Pubmed]
  25. Polymorphism of haptoglobin (HP), group specific component (GC) and alpha-1-antitrypsin (PI) in the resident population of the Basque Country (Spain). García-Orad, A., Arizti, P., Esteban, J.L., García-Orad, C., García-Arenzana, C., Constans, J., de Pancorbo, M.M. Gene geography : a computerized bulletin on human gene frequencies. (1990) [Pubmed]
  26. Biometric analysis of phenotypic characters of potato shoot-tips recovered from tissue culture, dimethyl sulphoxide treatment and cryopreservation. Harding, K., Staines, H. Cryo letters. (2001) [Pubmed]
  27. Qualitative study of ethanol content in tequilas by Raman spectroscopy and principal component analysis. Frausto-Reyes, C., Medina-Gutiérrez, C., Sato-Berrú, R., Sahagún, L.R. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. (2005) [Pubmed]
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