Disease relevance of Dalargin

• Dalargin is reported to prevent heart rhythm disturbance and heart electrical stability decrease in experimental coronary occlusion, postinfarction, cardiosclerosis and emotional stress [1].
• Oxidative modification of plasma proteins during hypothermia and after dalargin administration [2].
• Misoprostol was significantly more effective than dalargin in inducing duodenal ulcer healing, both in the intent-to-treat cohort (P = .001) and in the evaluable cohort (P = .0001) [3].
• It should be noted that dalargin caused tachycardia in some animals [4].
• Intravenous infusion of D-Ala2,Leu5,Arg6-enkephalin (dalargin) caused bradycardia in narcotized rats [4].

High impact information on Dalargin

• 4. Dalarginamide was more potent and selective for mu-opioid receptors than dalargin, whilst dalarginethylamide, though equipotent to dalarginamide in the myenteric plexus, was more potent at delta-opioid receptors (KB=5.0 nM) [5].
• 3. [Met5]-dalargin was equipotent to dalargin in the myenteric plexus, but was more potent in the vasa deferentia of hamster and mouse (KB=5.5 nM) [5].
• Leu5 and the interdependence of Leu5 and D-Ala2 are of importance for the selectivity of dalargin for mu-opioid receptors [5].
• Selected analogues and fragments of enkephalins and dalargin were successfully separated by CZE in acidic isoelectric buffers, 100 and 200 mM iminodiacetic acid, pH 2.30 and 2.32, respectively [6].
• Only dalargin preadsorbed to PBCA nanoparticles was able to induce an antinociceptive effect in the animals [7].

Biological context of Dalargin

• Dalargin and (-)-U-50,488 added to Krebs-Henseleit perfusion solution for isolated rat heart decreased heart rate [4].

Anatomical context of Dalargin

• Transport of the hexapeptide dalargin across the blood-brain barrier was accomplished using a nanoparticle formulation [8].
• Opioid peptides leu-enkephalin, a synthetic analog of enkephalin dalargin and an opiate receptor blocker naloxone were studied for their morphological effect on the cells of dissociated cultures of rat spinal cord [9].
• Dalargin prevents acute myocardial ischaemia-induced increase of cAMP content in blood serum and cardiac muscle, as an indirect feature of its antiadrenergic activity [1].
• Stimulation and blockade of opiate receptors in the central amygdaloid nucleus and lateral hypothalamus with dalargin and naloxone induced the same effect [10].
• The positive chronotropic effect of dalargin is probably related to modulation of the parasympathetic autonomic nervous system [4].

Associations of Dalargin with other chemical compounds

• Furthermore, the antinociceptive threshold of polysorbate 80-coated dalargin-loaded nanoparticles was determined in ApoEtm1Unc and C57BL/6J mice [11].
• In earlier studies we demonstrated central analgesic effects of a peptide, dalargin (dal), after systemic administration when this substance was bound onto the surface of polybutylcyanoacrylate nanoparticles and coated with polysorbate 80 but not when it was given alone [12].

Gene context of Dalargin

• Poly(butyl cyanoacrylate) nanoparticles loaded with the hexapeptide dalargin were coated with the apolipoproteins AII, B, CII, E, or J without or after precoating with polysorbate 80 [11].
• We studied antiarrhythmic action of D-Ala 2, Leu 5, Arg 6-enkephalin (dalargin) in experiments on male rats [1].
• The data strongly suggest that cGMP content increase and somatostatin level decrease in cardiac muscle play a significant role in antiarrhythmic action of dalargin [1].

Analytical, diagnostic and therapeutic context of Dalargin

• We show by in situ brain perfusion that vectorization markedly enhances the brain uptake of dalargin [13].
• Activity profiles of dalargin and its analogues in mu-, delta- and kappa-opioid receptor selective bioassays [5].
• Double-coated poly (butylcynanoacrylate) nanoparticulate delivery systems for brain targeting of dalargin via oral administration [14].
• Results from the tail flick test indicated that significant dalargin-induced analgesia was observed from PBCA-NDSs with double-coating of Tween and PEG in comparison with single-coating of either Tween or PEG [14].
• Dalargin adsorption was assessed by HPLC [15].

References