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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

AMIFLOXACIN     6-fluoro-1-methylamino-7-(4...

Synonyms: Amifloxacine, Amifloxacino, Amifloxacinum, CHEMBL6231, SureCN48001, ...
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Disease relevance of Win 49375


High impact information on Win 49375


Chemical compound and disease context of Win 49375


Anatomical context of Win 49375

  • Clinical and pharmacokinetic data suggest that orally administered amifloxacin may have utility in the treatment of urinary tract infections [8].

Associations of Win 49375 with other chemical compounds


Analytical, diagnostic and therapeutic context of Win 49375


  1. In vitro activity of amifloxacin against outer membrane mutants of the family Enterobacteriaceae and frequency of spontaneous resistance. Watanabe, M., Inoue, M., Mitsuhashi, S. Antimicrob. Agents Chemother. (1989) [Pubmed]
  2. Antimicrobial spectrum of Win 49375. Jacobus, N.V., Tally, F.P., Barza, M. Antimicrob. Agents Chemother. (1984) [Pubmed]
  3. In vitro comparison of amifloxacin and six other antibiotics against aminoglycoside-resistant Pseudomonas aeruginosa. Thompson, K.D., O'Keefe, J.P., Tatarowicz, W.A. Antimicrob. Agents Chemother. (1984) [Pubmed]
  4. Amifloxacin activity against well-defined gentamicin-resistant, gram-negative bacteria. John, J.F., Twitty, J.A. Antimicrob. Agents Chemother. (1984) [Pubmed]
  5. In vitro activity of WIN 49375 compared with those of other antibiotics in isolates from cancer patients. Garcia, I., Bodey, G.P., Fainstein, V., Ho, D.H., LeBlanc, B. Antimicrob. Agents Chemother. (1984) [Pubmed]
  6. Preliminary study of the pharmacokinetics of oral amifloxacin in elderly subjects. Stroshane, R.M., Silverman, M.H., Sauerschell, R., Brown, R.R., Boddy, A.W., Cook, J.A. Antimicrob. Agents Chemother. (1990) [Pubmed]
  7. Randomized, controlled trial of a 10-day course of amifloxacin versus trimethoprim-sulfamethoxazole in the treatment of acute, uncomplicated urinary tract infection. Amifloxacin Multi-Center Trial Group. Boyko, E.J., Iravani, A., Silverman, M.H., Schelling, D.J., Wright, R.A. Antimicrob. Agents Chemother. (1990) [Pubmed]
  8. Multiple-dose pharmacokinetics and safety of oral amifloxacin in healthy volunteers. Cook, J.A., Silverman, M.H., Schelling, D.J., Nix, D.E., Schentag, J.J., Brown, R.R., Stroshane, R.M. Antimicrob. Agents Chemother. (1990) [Pubmed]
  9. In vitro susceptibilities of 393 recent clinical isolates to WIN 49375, cefotaxime, tobramycin, and piperacillin. Pohlod, D.J., Saravolatz, L.D. Antimicrob. Agents Chemother. (1984) [Pubmed]
  10. In vitro and in vivo antibacterial activities of the fluoroquinolone WIN 49375 (amifloxacin). Cornett, J.B., Wagner, R.B., Dobson, R.A., Wentland, M.P., Bailey, D.M. Antimicrob. Agents Chemother. (1985) [Pubmed]
  11. Comparative antimicrobial activity of enoxacin, ciprofloxacin, amifloxacin, norfloxacin and ofloxacin against 177 bacterial isolates. Bassey, C.M., Baltch, A.L., Smith, R.P. J. Antimicrob. Chemother. (1986) [Pubmed]
  12. In vitro activity of amifloxacin (WIN 49,375) compared with those of ciprofloxacin and ofloxacin. Digranes, A. Acta pathologica, microbiologica, et immunologica Scandinavica. Section B, Microbiology. (1987) [Pubmed]
  13. Amifloxacin distribution in the dog prostate. Frimodt-Møller, P.C., Dørflinger, T., Madsen, P.O. Prostate (1985) [Pubmed]
  14. Reversed-phase ion-pair high-performance liquid chromatographic determination of fluoroquinolones in human plasma. Nangia, A., Lam, F., Hung, C.T. Journal of pharmaceutical sciences. (1990) [Pubmed]
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