Disease relevance of Sesamolin

• The neuroprotective effects of sesame antioxidants, sesamin and sesamolin, against hypoxia or H2O2-induced cell injury were evaluated by cell viability or lactate dehydrogenase (LDH) activity [1].
• The exposure of human lymphoid leukemia Molt 4B cells to sesamolin, a component of sesame seed led to both growth inhibition and the induction of apoptosis [2].
• Oxidative Toxicity in BV-2 Microglia Cells: Sesamolin Neuroprotection of H2O2 Injury Involving Activation of p38 Mitogen-Activated Protein Kinase [3].

High impact information on Sesamolin

• Protective effects of sesamin and sesamolin on hypoxic neuronal and PC12 cells [1].
• To determine the ability of sesamolin to act as an antioxidant in vivo, we fed rats a diet containing 1% sesamolin for 2 wk and studied its metabolism and its effects on oxidative stress [4].
• Sesamolin inhibits lipid peroxidation in rat liver and kidney [4].
• About 75% of the ingested sesamolin was excreted unmetabolized in feces, but it was not detected in urine [4].
• Sesamin and sesamolin also reduced LPS-activated p38 mitogen-activated protein kinase (MAPK) and nuclear factor (NF)-kappaB activations [5].

Chemical compound and disease context of Sesamolin

• Sesamin and sesamolin reduced LDH release of PC12 cells under hypoxia or H2O2-stress in a dose-dependent manner [1].

Biological context of Sesamolin

• These results suggest that sesamolin and its metabolites may contribute to the antioxidative properties of sesame seeds and oil and support our hypothesis that sesame lignans reduce susceptibility to oxidative stress [4].
• Sesamin and sesamolin were tested for their ability to protect BV-2 microglia from hypoxia-induced cell death [6].
• Taken together, the inhibition of NO production might be due to the reduction of LPS-induced p38 MAPK signal pathway by sesamin and sesamolin [7].
• These findings suggest that growth inhibition of Molt 4B cells by sesamolin results from the induction of apoptosis in the cells [2].

Anatomical context of Sesamolin

• In this study, we focused on the effect of sesamin and sesamolin, on nitric oxide (NO) induction by lipopolysaccharides (LPS) in the murine microglial cell line BV-2 and rat primary microglia [7].
• Since detoxifying enzymes are localized in microsomes, the inhibitory effects of sesamin and sesamolin observed in the microsomal system may be attributed to their metabolites [8].

Associations of Sesamolin with other chemical compounds

• Sesame (Sesamum indicum L.) contains abundant lignans including lipid-soluble lignans (sesamin and sesamolin) and water-soluble lignan glycosides (sesaminol triglucoside and sesaminol diglucoside) related to antioxidative activity [9].
• Sesamol containing a free phenolic group inhibited lipid peroxidation in both the systems whereas sesamin and sesamolin having methylenedioxy groups were effective only in the microsomal system [8].
• In addition, sesamolin preserved superoxide dismutase and catalase activities in BV-2 cells under H(2)O(2) stress [3].

Gene context of Sesamolin

• The sesamin or sesamolin reduced caspase-3 and MAPK activation correlated well with diminished LDH release in BV-2 cells under hypoxia [6].
• Sesamin or sesamolin significantly reduced LPS-activated p38 MAPK of BV-2 cells [7].
• The results showed that sesamin and sesamolin significantly inhibited NO production, iNOS mRNA and protein expression in LPS-stimulated BV-2 cells [7].
• Sesamolin was able to inhibit H(2)O(2)-induced p38 MAPK and caspase-3 activation and cell death [3].

References