Disease relevance of Sesaminol

• The exposure of human lymphoid leukemia Molt 4B cells to sesaminol, a component of sesame oil led to both growth inhibition and the induction of apoptosis [1].
• In this study, we have investigated protective effects of sesaminol glucosides on Abeta-induced oxidative cell death in cultured rat pheochromocytoma (PC12) cells [2].
• The dietary sesamin and sesaminol lowered the TBARS concentrations and decreased the red blood hemolysis [3].
• The effects of sesaminol and sesamin on the ethanol-induced modulation of immune indices related to food allergy were examined in rats given a low (10%)-casein diet [4].

High impact information on Sesaminol

• Sesame (Sesamum indicum L.) contains abundant lignans including lipid-soluble lignans (sesamin and sesamolin) and water-soluble lignan glycosides (sesaminol triglucoside and sesaminol diglucoside) related to antioxidative activity [5].
• Calibration equations for lignans (sesamin and sesamolin) and lignan glycosides (sesaminol triglucoside and sesaminol diglucoside) contents were developed using modified partial least squares regression with internal cross-validation (n = 63) [5].
• Inhibitory effect of sesaminol glucosides on lipopolysaccharide-induced NF-kappaB activation and target gene expression in cultured rat astrocytes [6].
• Consistent with the inhibitory effect on Abeta25-35-induced stress-induced cell death, sesaminol glucosides decreased expression of pro-apoptotic gene p53, and Bax and caspase-3, but enhanced expression of anti-apoptotic Bcl-2 [2].
• Antioxidative catechol lignans converted from sesamin and sesaminol triglucoside by culturing with Aspergillus [7].

Biological context of Sesaminol

• These findings suggest that growth inhibition of Molt 4B cells by sesaminol results from the induction of apoptosis in the cells [1].
• Moreover, the protective effects of sesaminol glucoside on Abeta25-35-induced ROS generation, NF-kappaB activation and cell death were further enhanced with glutathione [2].
• In addition, as determined by the secondary products of lipid peroxidation identified by using immunochemical methods, sesaminol completely inhibited the formation of 4-hydroxy-nonenal (4-HNE)- and malondialdehyde (MDA)-adducts in a concentration-dependent manner [8].
• Sesaminol inhibited the Cu2+-induced lipid peroxidation in LDL in a concentration-dependent manner with an IC50 36.0 +/- 10.0 nM [8].

Anatomical context of Sesaminol

• Effect of sesaminol glucosides on beta-amyloid-induced PC12 cell death through antioxidant mechanisms [2].

Gene context of Sesaminol

• We investigated the antioxidant properties of sesaminol, a major component of sesame oil, on the oxidative modification of human low-density lipoprotein (LDL) in vitro [8].

Analytical, diagnostic and therapeutic context of Sesaminol

• HPLC analysis of sesaminol glucosides in sesame seeds [9].

References