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Chemical Compound Review

androsterone     (3R,5S,8R,9S,10S,13S,14S)-3- hydroxy-10,13...

Synonyms: Androtin, Androtine, Androkinin, Androkinine, UPCMLD-DP124, ...
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Disease relevance of androsterone


High impact information on androsterone

  • It is postulated that the conjugating activity of UGT enzymes is the main mechanism for modulating the action of steroids and protecting the androgen-sensitive tissues from deleteriously high concentrations of DHT, ADT and 3alpha-DIOL [4].
  • The predominant androgen produced by progenitor, immature, and adult Leydig cells differed, with AO being released by progenitor cells (72.08 +/- 9.02% of total androgens), 3alpha-DIOL by immature Leydig cells (73.33 +/- 14.52%), and T by adult Leydig cells (74.38 +/- 14.73%) [5].
  • Mouse rdh6 encodes cis-retinoid/androgen dehydrogenase type 1 (CRAD1), a short-chain dehydrogenase, which recognizes as substrates 9-cis-retinol, 11-cis-retinol, 5 alpha-androstan-3 alpha,17 beta-diol and 5 alpha-androstan-3 alpha-ol-17-one, and is expressed most intensely in liver and kidney [6].
  • Sertoli cells from immature rats metabolized (3H) 5 alpha-androstane-3 alpha, 17 beta-diol to (3H) 5 alpha-androstane-3 alpha, 16 alpha, 17 beta-triol and (3H) 3 alpha-hydroxy-5 alpha-androstan-17-one [7].
  • UGT2B17 is a UDP-glucuronosyltransferase enzyme expressed in several extrahepatic steroid target tissues, including the human prostate, where it glucuronidates C19 steroids such as dihydrotestosterone (DHT), androsterone (ADT), and androstane-3alpha, 17beta-diol (3alpha-diol) [8].

Biological context of androsterone


Anatomical context of androsterone


Associations of androsterone with other chemical compounds


  1. Urinary aetiocholanolone in patients with early breast cancer from South East Scotland and South Wales. Miller, W.R., Hamilton, T., Champion, H.R., Wallace, I.W., Forrest, A.P., Prescott, R.J., Cameron, E.H., Griffiths, K. Br. J. Cancer (1975) [Pubmed]
  2. Glucuronosyltransferase activity in human cancer cell line LNCaP. Guillemette, C., Bélanger, A. Mol. Cell. Endocrinol. (1995) [Pubmed]
  3. Urinary excretion of 17-oxosteroids in hereditary coproporphyria. Paxton, J.W., Moore, M.R., Beattie, A.D., Goldberg, A. Clinical science and molecular medicine. (1975) [Pubmed]
  4. Inactivation of androgens by UDP-glucuronosyltransferase enzymes in humans. Bélanger, A., Pelletier, G., Labrie, F., Barbier, O., Chouinard, S. Trends Endocrinol. Metab. (2003) [Pubmed]
  5. Variation in the end products of androgen biosynthesis and metabolism during postnatal differentiation of rat Leydig cells. Ge, R.S., Hardy, M.P. Endocrinology (1998) [Pubmed]
  6. Structure, promoter and chromosomal localization of rdh6. Chai, X., Chen, W., Napoli, J.L. Gene (2001) [Pubmed]
  7. Metabolism of (3H) 5 alpha-androstane-3 alpha, 17 beta-diol by cultures of isolated rat sertoli cells and the effect of LH and FSH. Tcholakian, R.K., Berkowitz, A.S., Newaz, S.N. Steroids (1984) [Pubmed]
  8. Chromosomal localization, structure, and regulation of the UGT2B17 gene, encoding a C19 steroid metabolizing enzyme. Beaulieu, M., Lévesque, E., Tchernof, A., Beatty, B.G., Bélanger, A., Hum, D.W. DNA Cell Biol. (1997) [Pubmed]
  9. Serum levels of unconjugated aetiocholanolone androstenedione, testosterone, dehydroepiandrosterone, aldosterone, progesterone and oestrogens during the normal menstrual cycle. Frölich, M., Brand, E.C., van Hall, E.V. Acta Endocrinol. (1976) [Pubmed]
  10. Alkaline phosphatase as a marker of maturity in human neutrophils. Studies in normals dosed with aetiocholanolone and prednisolone. Mishler, J.M., Williams, D.M. J. Clin. Pathol. (1980) [Pubmed]
  11. Male pseudohermaphroditism due to primary 5 alpha-reductase deficiency: variation in gender identity reversal in seven Mexican patients from five different pedigrees. Méndez, J.P., Ulloa-Aguirre, A., Imperato-McGinley, J., Brugmann, A., Delfin, M., Chávez, B., Shackleton, C., Kofman-Alfaro, S., Pérez-Palacios, G. J. Endocrinol. Invest. (1995) [Pubmed]
  12. Cellular specific expression of the androgen-conjugating enzymes UGT2B15 and UGT2B17 in the human prostate epithelium. Chouinard, S., Pelletier, G., Bélanger, A., Barbier, O. Endocr. Res. (2004) [Pubmed]
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