Gene Review:
UGT2B17 - UDP glucuronosyltransferase 2 family,...
Homo sapiens
Synonyms:
BMND12, C19-steroid-specific UDP-glucuronosyltransferase, C19-steroid-specific UDPGT, UDP-glucuronosyltransferase 2B17, UDPGT 2B17, ...
Park,
Chen,
Ratnashinge,
Sellers,
Tanner,
Lee,
Dossett,
Lang,
Kadlubar,
Ambrosone,
Zachariah,
Heysek,
Patterson,
Pow-Sang,
Jakobsson,
Ekström,
Inotsume,
Garle,
Lorentzon,
Ohlsson,
Roh,
Carlström,
Rane,
Collier,
Ganley,
Tingle,
Blumenstein,
Marvin,
Paxton,
Mitchell,
Keelan,
Bauman,
Goosen,
Tugnait,
Peterkin,
Hurst,
Menning,
Milad,
Court,
Williams,
- Effect of interleukins on UGT2B15 and UGT2B17 steroid uridine diphosphate-glucuronosyltransferase expression and activity in the LNCaP cell line. Lévesque, E., Beaulieu, M., Guillemette, C., Hum, D.W., Bélanger, A. Endocrinology (1998)
- A UGT2B17-positive donor is a risk factor for higher transplant-related mortality and lower survival after bone marrow transplantation. Terakura, S., Murata, M., Nishida, T., Emi, N., Akatsuka, Y., Riddell, S.R., Morishima, Y., Kodera, Y., Naoe, T. Br. J. Haematol. (2005)
- Immunochemical analysis of uridine diphosphate-glucuronosyltransferase in four patients with the Crigler-Najjar syndrome type I. van Es, H.H., Goldhoorn, B.G., Paul-Abrahamse, M., Elferink, R.P., Jansen, P.L. J. Clin. Invest. (1990)
- Mechanism of thiazopyr-induced effects on thyroid hormone homeostasis in male Sprague-Dawley rats. Hotz, K.J., Wilson, A.G., Thake, D.C., Roloff, M.V., Capen, C.C., Kronenberg, J.M., Brewster, D.W. Toxicol. Appl. Pharmacol. (1997)
- A human minor histocompatibility antigen resulting from differential expression due to a gene deletion. Murata, M., Warren, E.H., Riddell, S.R. J. Exp. Med. (2003)
- Increased UDP-glucuronosyltransferase activity and decreased prostate specific antigen production by biochanin A in prostate cancer cells. Sun, X.Y., Plouzek, C.A., Henry, J.P., Wang, T.T., Phang, J.M. Cancer Res. (1998)
- Gene therapy with bilirubin-UDP-glucuronosyltransferase in the Gunn rat model of Crigler-Najjar syndrome type 1. Li, Q., Murphree, S.S., Willer, S.S., Bolli, R., French, B.A. Hum. Gene Ther. (1998)
- Isolation and characterization of a novel cDNA encoding a human UDP-glucuronosyltransferase active on C19 steroids. Beaulieu, M., Lévesque, E., Hum, D.W., Bélanger, A. J. Biol. Chem. (1996)
- Isolation and characterization of the human UGT2B15 gene, localized within a cluster of UGT2B genes and pseudogenes on chromosome 4. Turgeon, D., Carrier, J.S., Lévesque, E., Beatty, B.G., Bélanger, A., Hum, D.W. J. Mol. Biol. (2000)
- Alteration of human UDP-glucuronosyltransferase UGT2B17 regio-specificity by a single amino acid substitution. Dubois, S.G., Beaulieu, M., Lévesque, E., Hum, D.W., Bélanger, A. J. Mol. Biol. (1999)
- Large differences in testosterone excretion in Korean and Swedish men are strongly associated with a UDP-glucuronosyl transferase 2B17 polymorphism. Jakobsson, J., Ekström, L., Inotsume, N., Garle, M., Lorentzon, M., Ohlsson, C., Roh, H.K., Carlström, K., Rane, A. J. Clin. Endocrinol. Metab. (2006)
- UDP-glucuronosyltransferase activity, expression and cellular localization in human placenta at term. Collier, A.C., Ganley, N.A., Tingle, M.D., Blumenstein, M., Marvin, K.W., Paxton, J.W., Mitchell, M.D., Keelan, J.A. Biochem. Pharmacol. (2002)
- Cellular specific expression of the androgen-conjugating enzymes UGT2B15 and UGT2B17 in the human prostate epithelium. Chouinard, S., Pelletier, G., Bélanger, A., Barbier, O. Endocr. Res. (2004)
- Tissue specific differences in the regulation of the UDP glucuronosyltransferase 2B17 gene promoter. Gregory, P.A., Hansen, A.J., Mackenzie, P.I. Pharmacogenetics (2000)
- Relative enzymatic activity, protein stability, and tissue distribution of human steroid-metabolizing UGT2B subfamily members. Turgeon, D., Carrier, J.S., Lévesque, E., Hum, D.W., Bélanger, A. Endocrinology (2001)
- Chromosomal localization, structure, and regulation of the UGT2B17 gene, encoding a C19 steroid metabolizing enzyme. Beaulieu, M., Lévesque, E., Tchernof, A., Beatty, B.G., Bélanger, A., Hum, D.W. DNA Cell Biol. (1997)
- Isoform-Specific Regulation of Uridine Diphosphate-Glucuronosyltransferase 2B Enzymes in the Human Prostate: Differential Consequences for Androgen and Bioactive Lipid Inactivation. Chouinard, S., Pelletier, G., B??langer, A., Barbier, O. Endocrinology (2006)
- Udp-glucuronosyltransferase 2b7 is the major enzyme responsible for gemcabene glucuronidation in human liver microsomes. Bauman, J.N., Goosen, T.C., Tugnait, M., Peterkin, V., Hurst, S.I., Menning, L.C., Milad, M., Court, M.H., Williams, J.A. Drug Metab. Dispos. (2005)
- The homeodomain Pbx2-Prep1 complex modulates hepatocyte nuclear factor 1alpha-mediated activation of the UDP-glucuronosyltransferase 2B17 gene. Gregory, P.A., Mackenzie, P.I. Mol. Pharmacol. (2002)
- Isolation and characterization of a simian UDP-glucuronosyltransferase UGT2B18 active on 3-hydroxyandrogens. Beaulieu, M., Lévesque, E., Barbier, O., Turgeon, D., Bélanger, G., Hum, D.W., Bélanger, A. J. Mol. Biol. (1998)
- Deletion polymorphism of UDP-glucuronosyltransferase 2B17 and risk of prostate cancer in African American and Caucasian men. Park, J., Chen, L., Ratnashinge, L., Sellers, T.A., Tanner, J.P., Lee, J.H., Dossett, N., Lang, N., Kadlubar, F.F., Ambrosone, C.B., Zachariah, B., Heysek, R.V., Patterson, S., Pow-Sang, J. Cancer Epidemiol. Biomarkers Prev. (2006)
- Evidence that tacrolimus augments the bioavailability of mycophenolate mofetil through the inhibition of mycophenolic acid glucuronidation. Zucker, K., Tsaroucha, A., Olson, L., Esquenazi, V., Tzakis, A., Miller, J. Therapeutic drug monitoring. (1999)