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Chemical Compound Review

Cytostatin     [(8E,10E,12E)-7-hydroxy-6- methyl-2-(3...

Synonyms: AC1O3ER5, 156856-30-3
 
 
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Disease relevance of Cytostatin

 

High impact information on Cytostatin

 

Anatomical context of Cytostatin

 

Associations of Cytostatin with other chemical compounds

  • Furthermore, cytostatin increased intracellular serine/threonine-phosphorylated proteins and was found to be a selective inhibitor of protein phosphatase 2A (PP2A) [8].
 

Gene context of Cytostatin

 

Analytical, diagnostic and therapeutic context of Cytostatin

References

  1. Cytostatin, a novel inhibitor of cell adhesion to components of extracellular matrix produced by Streptomyces sp. MJ654-NF4. II. Physico-chemical properties and structure determination. Amemiya, M., Someno, T., Sawa, R., Naganawa, H., Ishizuka, M., Takeuchi, T. J. Antibiot. (1994) [Pubmed]
  2. Cytostatin, a novel inhibitor of cell adhesion to components of extracellular matrix produced by Streptomyces sp. MJ654-NF4. I. Taxonomy, fermentation, isolation and biological activities. Amemiya, M., Ueno, M., Osono, M., Masuda, T., Kinoshita, N., Nishida, C., Hamada, M., Ishizuka, M., Takeuchi, T. J. Antibiot. (1994) [Pubmed]
  3. Inhibitory effect of cytostatin on spontaneous lung metastases of B16-BL6 melanoma cells. Masuda, T., Watanabe, S., Amemiya, M., Ishizuka, M., Takeuchi, T. J. Antibiot. (1995) [Pubmed]
  4. Specific inhibitors of protein phosphatase 2A inhibit tumor metastasis through augmentation of natural killer cells. Kawada, M., Kawatsu, M., Masuda, T., Ohba, S., Amemiya, M., Kohama, T., Ishizuka, M., Takeuchi, T. Int. Immunopharmacol. (2003) [Pubmed]
  5. Total synthesis and evaluation of cytostatin, its C10-C11 diastereomers, and additional key analogues: impact on PP2A inhibition. Lawhorn, B.G., Boga, S.B., Wolkenberg, S.E., Colby, D.A., Gauss, C.M., Swingle, M.R., Amable, L., Honkanen, R.E., Boger, D.L. J. Am. Chem. Soc. (2006) [Pubmed]
  6. Total synthesis and biological evaluation of the protein phosphatase 2A inhibitor cytostatin and analogues. Bialy, L., Waldmann, H. Chemistry (Weinheim an der Bergstrasse, Germany) (2004) [Pubmed]
  7. Differential induction of apoptosis in B16 melanoma and EL-4 lymphoma cells by cytostatin and bactobolin. Kawada, M., Amemiya, M., Ishizuka, M., Takeuchi, T. Jpn. J. Cancer Res. (1999) [Pubmed]
  8. Cytostatin, an inhibitor of cell adhesion to extracellular matrix, selectively inhibits protein phosphatase 2A. Kawada, M., Amemiya, M., Ishizuka, M., Takeuchi, T. Biochim. Biophys. Acta (1999) [Pubmed]
  9. Screening for apoptosis inducers in microbial products and induction of apoptosis by cytostatin. Yamazaki, K., Amemiya, M., Ishizuka, M., Takeuchi, T. J. Antibiot. (1995) [Pubmed]
 
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