The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

AG-F-81255     hydroxy-(hydroxy-oxo- phosphaniumyl)oxy-oxo...

Synonyms: CHEBI:29205, CTK1H2827, AC1O3F29, H2P2H2O5, 36465-90-4, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of H2P2H2O5


High impact information on H2P2H2O5

  • 99mTc-labelled derivatives of aminomethane diphosphonic acid, general formula: R1R2N-CR3 [PO(OH)2]2, as well as hydroxyethane diphosphonic acid and hydroxypropane monophosphonic acid were investigated with regard to their suitability for skeleton scintigraphy [6].
  • The rates of dissolution of calcitic Carrara marble have been reported to be significantly reduced in alkaline pH (pH 8.25) at 25 degrees C in the presence of (1-hydroxyethylidene)-1,1 diphosphonic acid (HEDP) [7].
  • The steady-state kinetic experiments suggest that magnesium adenosine triphosphate (MgATP), adenylyl (beta,gamma-methylene) diphosphonic acid (MgAMP-PCP) and magnesium adenosine diphosphate (MgADP) bind p38 MAPKalpha with dissociation constants of KA = 360 microm, KI = 240 microm, and KI > 2000 microm, respectively [8].
  • Complexometric determination of diphosphonic acid derivatives. Part II [9].
  • Pain originating from the hyperostosis could be suppressed by the disodium salt of (1-hydroxyethylidene) diphosphonic acid [10].

Chemical compound and disease context of H2P2H2O5


Associations of H2P2H2O5 with other chemical compounds

  • Whole-body retention (WBR) was measured together with regional uptakes in the following four areas: head, chest, bladder, and legs using two structurally related Tc-99m-diphosphonate skeletal imaging agents: 1-hydroxyethylidene diphosphonate (HEDP) and methylene diphosphonate (MDP) [11].

Analytical, diagnostic and therapeutic context of H2P2H2O5


  1. Bone scan patterns in acute osteomyelitis. Scoles, P.V., Hilty, M.D., Sfakianakis, G.N. Clin. Orthop. Relat. Res. (1980) [Pubmed]
  2. Effect of dichloromethylene diphosphonate on bone metabolism in calcium and phosphorus-depleted rats. Evans, R.A., Wergedal, J.E., Baylink, D.J. Mineral and electrolyte metabolism. (1983) [Pubmed]
  3. Prophylactic treatment of skeletal metastases, tumor-induced osteolysis, and hypercalcemia in rats with the bisphosphonate Cl2MBP. Krempien, B., Manegold, C. Cancer (1993) [Pubmed]
  4. Extra-osseous localisation of 99Tcm methylene diphosphonic acid (MDP) in a primary neuroblastoma. Murray, G.M., Greensmith, M.G. Pediatric radiology. (1978) [Pubmed]
  5. Tc-99m-diphosphonate distribution in a patient with hypercalcemia and metastatic calcifications. Arbona, G.L., Antonmattei, S., Tetalman, M.R., Scheu, J.D. Clinical nuclear medicine. (1980) [Pubmed]
  6. Chemical structure and pharmacokinetics of 99mTc-labelled aminomethane diphosphonic acid derivatives. Unterspann, S., Finck, W. European journal of nuclear medicine. (1981) [Pubmed]
  7. The interaction of diphosphonates with calcitic surfaces: understanding the inhibition activity in marble dissolution. Spanos, N., Kanellopoulou, D.G., Koutsoukos, P.G. Langmuir : the ACS journal of surfaces and colloids. (2006) [Pubmed]
  8. Kinetic mechanism for p38 MAP kinase alpha. A partial rapid-equilibrium random-order ternary-complex mechanism for the phosphorylation of a protein substrate. Szafranska, A.E., Dalby, K.N. FEBS J. (2005) [Pubmed]
  9. Complexometric determination of diphosphonic acid derivatives. Part II. Podolska, M., Białecka, W., Kwiatkowska-Puchniarz, B. Acta poloniae pharmaceutica. (2000) [Pubmed]
  10. Melorheostosis of the upper limb: a report of two cases. Kawabata, H., Tsuyuguchi, Y., Kawai, H., Yasui, N. The Journal of hand surgery. (1984) [Pubmed]
  11. Whole body and regional retention of Tc-99m-labeled diphosphonates with a whole-body counter: a study with normal males. Molloi, S., Mazess, R., Bendsen, H., Wilson, M. Calcif. Tissue Int. (1989) [Pubmed]
  12. Comparison of 99mTc-labeled phosphate and phosphonate agents for skeletal imaging. Davis, M.A., Jones, A.L. Seminars in nuclear medicine. (1976) [Pubmed]
  13. Voltammetry as a virtual potentiometric sensor in modelling of a metal-ligand system and refinement of stability constants. Part 4. An electrochemical study of NiII complexes with methylene diphosphonic acid. Cukrowski, I., Mogano, D.M., Zeevaart, J.R. J. Inorg. Biochem. (2005) [Pubmed]
  14. Effect of 1-hydroxyethane-1,1-diphosphonic acid (HEDP) on new bone formation induced by bone matrix gelatin (BMG). Yamashita, K., Kuwahara, M., Ishizuka, H. Acta Histochem. (1994) [Pubmed]
WikiGenes - Universities