Disease relevance of phosphonomethylphosphonic acid

• Scintigraphic imaging with (99m)Tc-methylene diphosphonate (MDP), or bone scanning, is much more sensitive in detecting acute osteomyelitis but lacks specificity [1].
• It was concluded that a greater decrease in Ga-67 than in Tc-99m MDP uptake often occurs in patients successfully treated for primary Ewing sarcoma [2].
• One hundred thirty patients with lung cancer were studied to determine the incidence of unilateral thoracic soft-tissue accumulation (UTS) of 99mTc methylene diphosphonate (MDP) [3].
• Osteomyelitis and soft-tissue infection: differential diagnosis with 24 hour/4 hour ratio of Tc-99m MDP uptake [4].
• 99mTc-Hydroxymethylene diphosphonate (HMDP) was compared to 99mTc-methylene diphosphonate (MDP) with respect to image quality, lesion detectability, and the uptake ratios of normal bone to soft tissue (B/S), metastatic bone to soft tissue (M/S) and bone metastases to normal bone (M/B) at 2 and 3 h after injection in the same subjects [5].

High impact information on phosphonomethylphosphonic acid

• The uptake in the affected region did not differ significantly between the agents, although 99mTc-MDP tended to have higher values (MDP, 4.75 +/- 1.23 percentage injected dose per gram [%ID/g]; 67Ga, 2.05 +/- 0.54 %ID/g; granulocytes, 1.56 +/- 0.83 %ID/g; liposomes, 1.75 +/- 0.76 %ID/g, and IgG, 1.96 +/- 0.27 %ID/g) [6].
• Periarticular bone sites associated with traumatic injury: false-positive findings with In-111-labeled white blood cell and Tc-99m MDP scintigraphy [7].
• While avid accumulation of gallium-67 citrate and technetium-99m methylene diphosphonate (MDP) occurs initially in most cases of primary Ewing sarcoma, uptake after therapy is less well defined [2].
• Bone formation in the elongated zone was studied by computed tomography and [99mTc] methylene diphosphonate (MDP) scintigraphy [8].
• Three patients with total knee arthroplasties, in which the tibial and patellar articulating surfaces consisted of a polyethylene-carbon fiber composite, demonstrated technetium-99m methylene diphosphonate (MDP) deposition in the intraarticular space, whereas, the gallium-67 citrate images were normal [9].

Chemical compound and disease context of phosphonomethylphosphonic acid

• This is a retrospective study of technetium-99m methylene diphosphonate (MDP) bone scans in 174 consecutive patients who were referred for the investigation of back pain in our department [10].

Biological context of phosphonomethylphosphonic acid

• Comparison of the kinetics of methylene-diphosphonate (MDP) and dicarboxypropan-diphosphonic acid (DPD), two radio-diagnostics for bone scintigraphy [11].
• Artifactual reduction in bone density as a result of technetium-99m MDP for bone scanning: report of two cases [12].
• The correlation between the uptake of Tc-99m MDP and the morphologic behavior of vascularized bone was investigated, simultaneously with bone labeling, contact microradiogram (CMR), and histology of an undecalcified sample [13].

Anatomical context of phosphonomethylphosphonic acid

• Clamping the hepatic artery had minimal effect on the retention of MDP when administered alone [14].
• Of the 18 cases whose 99mTc-methylene diphosphonate (MDP) bone scans showed hot spots in the lower lumbar region of the spine and/or the pelvic bone, 8 had normal bone-marrow scintigrams [15].
• MDP was injected regionally, via the hepatic artery, alone or co-administered with DSM, with or without subsequent occlusion of either the hepatic artery or the portal vein [14].
• Areas of slight methylene diphosphonate (MDP) uptake were found at every periprosthetic site and areas of discrete to marked MDP uptake were commonly found in the acetabulum and/or the greater trochanter with both loosened and painless prostheses and are thus considered to be nonspecific findings [16].
• Initial testing of the technique with methylene diphosphonate (MDP) bone studies produced tracer flow rates of 0.000366 s-1 into bone and 0.001525 s-1 into interstitial fluid in patients with no known bone disease [17].

Associations of phosphonomethylphosphonic acid with other chemical compounds

• This retrospective study was done to determine the value of combined bone (technetium-99m methylene-diphosphonate) and gallium-67 citrate imaging in selected children with complicated clinical situations [18].
• Twenty normal volunteers had measurements of 24-hr whole-body retention (WBR) of three structurally related Tc-99m-labeled phosphonate skeletal imaging agents: (1-hydroxyethylidene) diphosphonate (HEDP), methylene diphosphonate (MDP), and hydroxymethylene diphosphonate (HMDP) [19].
• In contrast to the reactivity of geranyl methylene-diphosphonate in the reaction catalyzed by farnesyl diphosphate synthase, that of isopentenyl methylenediphosphonate showed an optimum at a more acidic pH than that of isopentenyl diphosphate, and it was inhibited by magnesium ions under certain conditions [20].
• Reactions of cis-diamminedichloroplatinum(II) with phosphonoformic acid (PFA), phosphonoacetic acid (PAA), and methylenediphosphonic acid (MDP) yield various phosphonatoplatinum(II) chelates which were characterized by phosphorus-31 NMR spectroscopy [21].
• In a 40-year-old Hispanic woman with pain and swelling in the left knee with a prosthesis, the combination of Ga-67 citrate and Tc-99m methylene diphosphonate (MDP) scans was used to indicate that there was a septic prosthetic joint [22].

Gene context of phosphonomethylphosphonic acid

• A comparison of bone imaging with Tc-99m DPD and Tc-99m MDP: concise communication [23].
• A case of hepatocellular carcinoma demonstrating intense uptake of Tc-99m methylene diphosphonate (MDP) is described [24].
• Ipsilateral craniofacial uptake of Tc-99m MDP in nasopharyngeal carcinoma: incidence and implication [25].

Analytical, diagnostic and therapeutic context of phosphonomethylphosphonic acid

• Each patient underwent three-phase bone scanning with 99mTc-methylene diphosphonate (MDP) and dynamic and static MIBI scintigraphy [26].
• We undertook a retrospective study of 122 patients with ankle pain to determine the accuracy of bone scintigraphy using 99mTc-methylene diphosphonate (MDP) for detection of osteochondral talar dome fractures (OCTDF) [27].
• METHODS: After intravenous injection of 99mTc-methylene diphosphonate (MDP), standard radiographic arthrography was performed in 105 patients (107 prostheses) [28].
• The effect of degradable starch microspheres (DSM) on the intrahepatic distribution of a low molecular weight marker, 99Tcm-labelled methylene diphosphonate (MDP), was studied in rats with hypovascular HSN liver tumours [14].
• The purpose of this study was to compare positron emission tomography using fluorine-18 fluorodeoxyglucose (FDG-PET) and technetium-99m methylene diphosphonate (MDP) bone scintigraphy in the detection of osseous metastases from malignant primary osseous tumours [29].

References