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Disease relevance of Osteolysis


High impact information on Osteolysis

  • Mutations in TNFRSF11A, affecting the signal peptide of RANK, cause familial expansile osteolysis [6].
  • Familial expansile osteolysis (FEO, MIM 174810) is a rare, autosomal dominant bone disorder characterized by focal areas of increased bone remodelling [6].
  • TNF-alpha is the dominant cytokine in inflammatory osteolysis [7].
  • M-CSF mediates TNF-induced inflammatory osteolysis [7].
  • These data suggest that TNF regulates RANKL expression via IL-1, and, therefore, IL-1 plays a role in TNF-induced periarticular osteolysis [8].

Chemical compound and disease context of Osteolysis


Biological context of Osteolysis


Anatomical context of Osteolysis


Gene context of Osteolysis


Analytical, diagnostic and therapeutic context of Osteolysis


  1. Impaired intranuclear trafficking of Runx2 (AML3/CBFA1) transcription factors in breast cancer cells inhibits osteolysis in vivo. Javed, A., Barnes, G.L., Pratap, J., Antkowiak, T., Gerstenfeld, L.C., van Wijnen, A.J., Stein, J.L., Lian, J.B., Stein, G.S. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  2. Anti-alpha4 integrin antibody suppresses the development of multiple myeloma and associated osteoclastic osteolysis. Mori, Y., Shimizu, N., Dallas, M., Niewolna, M., Story, B., Williams, P.J., Mundy, G.R., Yoneda, T. Blood (2004) [Pubmed]
  3. Efficacy of etanercept for wear debris-induced osteolysis. Childs, L.M., Goater, J.J., O'Keefe, R.J., Schwarz, E.M. J. Bone Miner. Res. (2001) [Pubmed]
  4. Role of the bone marrow microenvironment in multiple myeloma. Roodman, G.D. J. Bone Miner. Res. (2002) [Pubmed]
  5. Basic fibroblast growth factor stimulates osteoclast recruitment, development, and bone pit resorption in association with angiogenesis in vivo on the chick chorioallantoic membrane and activates isolated avian osteoclast resorption in vitro. Collin-Osdoby, P., Rothe, L., Bekker, S., Anderson, F., Huang, Y., Osdoby, P. J. Bone Miner. Res. (2002) [Pubmed]
  6. Mutations in TNFRSF11A, affecting the signal peptide of RANK, cause familial expansile osteolysis. Hughes, A.E., Ralston, S.H., Marken, J., Bell, C., MacPherson, H., Wallace, R.G., van Hul, W., Whyte, M.P., Nakatsuka, K., Hovy, L., Anderson, D.M. Nat. Genet. (2000) [Pubmed]
  7. M-CSF mediates TNF-induced inflammatory osteolysis. Kitaura, H., Zhou, P., Kim, H.J., Novack, D.V., Ross, F.P., Teitelbaum, S.L. J. Clin. Invest. (2005) [Pubmed]
  8. IL-1 mediates TNF-induced osteoclastogenesis. Wei, S., Kitaura, H., Zhou, P., Ross, F.P., Teitelbaum, S.L. J. Clin. Invest. (2005) [Pubmed]
  9. Double-blind, placebo-controlled, dose-response trial of oral clodronate in patients with bone metastases. O'Rourke, N., McCloskey, E., Houghton, F., Huss, H., Kanis, J.A. J. Clin. Oncol. (1995) [Pubmed]
  10. Inhibition by diphosphonates of bone resorption induced by the Walker tumor of the rat. Jung, A., Bornand, J., Mermillod, B., Edouard, C., Meunier, P.J. Cancer Res. (1984) [Pubmed]
  11. Low-dose gallium nitrate for prevention of osteolysis in myeloma: results of a pilot randomized study. Warrell, R.P., Lovett, D., Dilmanian, F.A., Schneider, R., Heelan, R.T. J. Clin. Oncol. (1993) [Pubmed]
  12. The heat shock protein 90 inhibitor, 17-allylamino-17-demethoxygeldanamycin, enhances osteoclast formation and potentiates bone metastasis of a human breast cancer cell line. Price, J.T., Quinn, J.M., Sims, N.A., Vieusseux, J., Waldeck, K., Docherty, S.E., Myers, D., Nakamura, A., Waltham, M.C., Gillespie, M.T., Thompson, E.W. Cancer Res. (2005) [Pubmed]
  13. Light- and electron-microscopic evaluation of the effects of 1,25-dihydroxyvitamin D3 on bone of thyroparathyroidectomized rats. Weisbrode, S.E., Capen, C.C., Norman, A.W. Am. J. Pathol. (1979) [Pubmed]
  14. Myeloma cells suppress bone formation by secreting a soluble Wnt inhibitor, sFRP-2. Oshima, T., Abe, M., Asano, J., Hara, T., Kitazoe, K., Sekimoto, E., Tanaka, Y., Shibata, H., Hashimoto, T., Ozaki, S., Kido, S., Inoue, D., Matsumoto, T. Blood (2005) [Pubmed]
  15. Osteoprotegerin overexpression by breast cancer cells enhances orthotopic and osseous tumor growth and contrasts with that delivered therapeutically. Fisher, J.L., Thomas-Mudge, R.J., Elliott, J., Hards, D.K., Sims, N.A., Slavin, J., Martin, T.J., Gillespie, M.T. Cancer Res. (2006) [Pubmed]
  16. Sesquiterpene lactone parthenolide blocks lipopolysaccharide-induced osteolysis through the suppression of NF-kappaB activity. Yip, K.H., Zheng, M.H., Feng, H.T., Steer, J.H., Joyce, D.A., Xu, J. J. Bone Miner. Res. (2004) [Pubmed]
  17. A tapered titanium femoral stem inserted without cement in a total hip arthroplasty. Radiographic evaluation and stability. Mulliken, B.D., Bourne, R.B., Rorabeck, C.H., Nayak, N. The Journal of bone and joint surgery. American volume. (1996) [Pubmed]
  18. Marrow stromal cells and osteoclast precursors differentially contribute to TNF-alpha-induced osteoclastogenesis in vivo. Kitaura, H., Sands, M.S., Aya, K., Zhou, P., Hirayama, T., Uthgenannt, B., Wei, S., Takeshita, S., Novack, D.V., Silva, M.J., Abu-Amer, Y., Ross, F.P., Teitelbaum, S.L. J. Immunol. (2004) [Pubmed]
  19. Cathepsin K is the principal protease in giant cell tumor of bone. Lindeman, J.H., Hanemaaijer, R., Mulder, A., Dijkstra, P.D., Szuhai, K., Bromme, D., Verheijen, J.H., Hogendoorn, P.C. Am. J. Pathol. (2004) [Pubmed]
  20. Periprosthetic osteolysis: induction of vascular endothelial growth factor from human monocyte/macrophages by orthopaedic biomaterial particles. Miyanishi, K., Trindade, M.C., Ma, T., Goodman, S.B., Schurman, D.J., Smith, R.L. J. Bone Miner. Res. (2003) [Pubmed]
  21. Stress-induced osteolysis of the clavicle. Kaplan, P.A., Resnick, D. Radiology. (1986) [Pubmed]
  22. Prelymphomatous B cell hyperplasia in the bone marrow of interleukin-7 transgenic mice: precursor B cell dynamics, microenvironmental organization and osteolysis. Valenzona, H.O., Pointer, R., Ceredig, R., Osmond, D.G. Exp. Hematol. (1996) [Pubmed]
  23. Transforming growth factor beta regulates parathyroid hormone-related protein expression in MDA-MB-231 breast cancer cells through a novel Smad/Ets synergism. Lindemann, R.K., Ballschmieter, P., Nordheim, A., Dittmer, J. J. Biol. Chem. (2001) [Pubmed]
  24. Tumor necrosis factor-alpha mediates orthopedic implant osteolysis. Merkel, K.D., Erdmann, J.M., McHugh, K.P., Abu-Amer, Y., Ross, F.P., Teitelbaum, S.L. Am. J. Pathol. (1999) [Pubmed]
  25. The IkappaB kinase (IKK) inhibitor, NEMO-binding domain peptide, blocks osteoclastogenesis and bone erosion in inflammatory arthritis. Dai, S., Hirayama, T., Abbas, S., Abu-Amer, Y. J. Biol. Chem. (2004) [Pubmed]
  26. Polymorphisms in the interleukin-1 receptor antagonist and interleukin-6 genes affect risk of osteolysis in patients with total hip arthroplasty. Gordon, A., Kiss-Toth, E., Stockley, I., Eastell, R., Wilkinson, J.M. Arthritis Rheum. (2008) [Pubmed]
  27. Variation in the TNF gene promoter and risk of osteolysis after total hip arthroplasty. Wilkinson, J.M., Wilson, A.G., Stockley, I., Scott, I.R., Macdonald, D.A., Hamer, A.J., Duff, G.W., Eastell, R. J. Bone Miner. Res. (2003) [Pubmed]
  28. Prostaglandin E2 and cyclic AMP levels in human breast tumors. Feller, N., Malachi, T., Halbrecht, I. J. Cancer Res. Clin. Oncol. (1979) [Pubmed]
  29. Recombinant adeno-associated virus-mediated osteoprotegerin gene therapy inhibits wear debris-induced osteolysis. Ulrich-Vinther, M., Carmody, E.E., Goater, J.J., S balle, K., O'Keefe, R.J., Schwarz, E.M. The Journal of bone and joint surgery. American volume. (2002) [Pubmed]
  30. Hydroxyapatite does not improve the outcome of a bipolar hemiarthroplasty. Meijerink, H.J., Gardeniers, J.W., Buma, P., Lemmens, J.A., Schreurs, B.W. Clin. Orthop. Relat. Res. (2004) [Pubmed]
  31. Differential effects of oxidised and non-oxidised polyethylene particles on human monocyte/macrophages in vitro. Kamikawa, K., Harada, Y., Nagata, K., Moriya, H. The Journal of bone and joint surgery. British volume. (2001) [Pubmed]
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