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MeSH Review


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Disease relevance of Hyperostosis


High impact information on Hyperostosis

  • These data suggest that: (a) the hyperostosis and the metaphyseal long bone deformity in the present CMD patient might be explained by osteoclast dysfunction due to impaired expression of the osteoclast-reactive vacuolar proton pump; and (b) a protooncogene c-src was not associated with the pathogenesis of the present CMD patient [6].
  • Spinal hyperostosis and etretinate [7].
  • This region was analyzed because of the recent assignment to this chromosomal region of the gene causing van Buchem disease, a rare autosomal recessive condition with a hyperostosis similar to sclerosteosis [1].
  • Calcium pyrophosphate dihydrate crystal deposition disease with concurrent vertebral hyperostosis in a Barbary ape [8].
  • A naturally occurring nonsense truncation mutation of the inorganic pyrophosphate (PPi)-generating nucleoside triphosphate pyrophosphohydrolase (NTPPPH) PC-1 is associated with spinal and periarticular ligament hyperostosis and cartilage calcification in "tiptoe walking" (ttw) mice [9].

Chemical compound and disease context of Hyperostosis


Biological context of Hyperostosis


Anatomical context of Hyperostosis

  • There have been a very few reports where a tendency of hyperostosis was observed for ossification of the spinal ligaments such as OPLL, OYL and ASH [16].

Gene context of Hyperostosis

  • The twy mouse displays elevated osseous formation particularly in the spine, and the pathophysiological features resemble that of human ankylosing spinal hyperostosis [17].
  • It was found that the retinol level of plasma decreased in patients of both sexes suffering from rheumatoid arthritis and clinically active ankylosing spondylitis, but increased in female patients suffering from ankylosing hyperostosis connected with diabetes, and also in the diabetes group [18].
  • A generalized skeletal hyperostosis in two siblings caused by a novel mutation in the SOST gene [19].
  • Craniometaphyseal dysplasia--Jackson type (CMDJ) is an autosomal dominant bone dysplasia with hyperostosis and sclerosis of the skull and abnormal modelling of the metaphyses [20].
  • Significantly increased BMD was observed in patients with ankylosing spinal hyperostosis (ASH) in addition to OPLL [21].

Analytical, diagnostic and therapeutic context of Hyperostosis


  1. Localization of the gene for sclerosteosis to the van Buchem disease-gene region on chromosome 17q12-q21. Balemans, W., Van Den Ende, J., Freire Paes-Alves, A., Dikkers, F.G., Willems, P.J., Vanhoenacker, F., de Almeida-Melo, N., Alves, C.F., Stratakis, C.A., Hill, S.C., Van Hul, W. Am. J. Hum. Genet. (1999) [Pubmed]
  2. Oropharyngeal skeletal disease accompanying high bone mass and novel LRP5 mutation. Rickels, M.R., Zhang, X., Mumm, S., Whyte, M.P. J. Bone Miner. Res. (2005) [Pubmed]
  3. The diagnostic value of hyperostosis in midline subfrontal meningioma. Lee, K.F. Radiology. (1976) [Pubmed]
  4. Palaeopathology of spinal osteophytosis, vertebral ankylosis, ankylosing spondylitis, and vertebral hyperostosis. Rogers, J., Watt, I., Dieppe, P. Ann. Rheum. Dis. (1985) [Pubmed]
  5. Cortical hyperostosis following long-term administration of prostaglandin E1 in infants with cyanotic congenital heart disease. Ueda, K., Saito, A., Nakano, H., Aoshima, M., Yokota, M., Muraoka, R., Iwaya, T. J. Pediatr. (1980) [Pubmed]
  6. Bone marrow-derived osteoclast-like cells from a patient with craniometaphyseal dysplasia lack expression of osteoclast-reactive vacuolar proton pump. Yamamoto, T., Kurihara, N., Yamaoka, K., Ozono, K., Okada, M., Yamamoto, K., Matsumoto, S., Michigami, T., Ono, J., Okada, S. J. Clin. Invest. (1993) [Pubmed]
  7. Spinal hyperostosis and etretinate. Archer, C.B., Griffiths, W.A., MacDonald, L. Lancet (1987) [Pubmed]
  8. Calcium pyrophosphate dihydrate crystal deposition disease with concurrent vertebral hyperostosis in a Barbary ape. Kandel, R.A., Renlund, R.C., Cheng, P.T., Rapley, W.A., Mehren, K.G., Pritzker, K.P. Arthritis Rheum. (1983) [Pubmed]
  9. Matrix vesicle plasma cell membrane glycoprotein-1 regulates mineralization by murine osteoblastic MC3T3 cells. Johnson, K., Moffa, A., Chen, Y., Pritzker, K., Goding, J., Terkeltaub, R. J. Bone Miner. Res. (1999) [Pubmed]
  10. Diffuse hyperostosis associated with etretinate. Burge, S., Ryan, T. Lancet (1985) [Pubmed]
  11. Appearance of hyperostosis frontalis interna on indium-111 leukocyte scans: potential diagnostic pitfall. Floyd, J.L., Jackson, D.E., Carretta, R. J. Nucl. Med. (1986) [Pubmed]
  12. Cortical hyperostosis after administration of prostaglandin E. Dekel, S., Francis, M.J. J. Pediatr. (1981) [Pubmed]
  13. Cortical hyperostosis: a complication of prolonged prostaglandin infusion in infants awaiting cardiac transplantation. Woo, K., Emery, J., Peabody, J. Pediatrics (1994) [Pubmed]
  14. Ossification of the posterior longitudinal ligament, diffuse, idiopathic skeletal hyperostosis, abnormal retinol and retinol binding protein: a familial observation. De Bandt, M., Meyer, O., Fuster, J.M., Kahn, M.F. J. Rheumatol. (1995) [Pubmed]
  15. The bisphosphonate 2-PEBP inhibits cyclosporin A induced high-turnover osteopenia in the rat. Movsowitz, C., Epstein, S., Fallon, M., Ismail, F., Thomas, S. J. Lab. Clin. Med. (1990) [Pubmed]
  16. Schizophrenic psychosis with a tendency of systemic ossification. Fukunishi, I., Hosokawa, K. Jpn. J. Psychiatry Neurol. (1988) [Pubmed]
  17. Elevation of alkaline phosphatase activity induced by parathyroid hormone in osteoblast-like cells from the spinal hyperostotic mouse TWY (twy/twy). Terakado, A., Tagawa, M., Goto, S., Yamazaki, M., Moriya, H., Fujimura, S. Calcif. Tissue Int. (1995) [Pubmed]
  18. Comparative investigations on vitamin A level of plasma in some rheumatic diseases. Mézes, M., Bartosiewicz, G., Németh, J. Clin. Rheumatol. (1986) [Pubmed]
  19. A generalized skeletal hyperostosis in two siblings caused by a novel mutation in the SOST gene. Balemans, W., Cleiren, E., Siebers, U., Horst, J., Van Hul, W. Bone (2005) [Pubmed]
  20. Refinement of the chromosome 5p locus for craniometaphyseal dysplasia. Chandler, D., Tinschert, S., Lohan, K., Harrop, K., Goldblatt, J., Nagy, M., Hummel, S., Braun, H.S., Laing, N., Nürnberg, P. Hum. Genet. (2001) [Pubmed]
  21. Bone mineral density in patients with ossification of the posterior longitudinal ligament in the cervical spine. Yamauchi, T., Taketomi, E., Matsunaga, S., Sakou, T. J. Bone Miner. Metab. (1999) [Pubmed]
  22. Prostaglandin-induced hyperostosis. A case report. Drvaric, D.M., Parks, W.J., Wyly, J.B., Dooley, K.J., Plauth, W.H., Schmitt, E.W. Clin. Orthop. Relat. Res. (1989) [Pubmed]
  23. Increased concentrations of endogenous 13-cis- and all-trans-retinoic acids in diffuse idiopathic skeletal hyperostosis, as demonstrated by HPLC. Periquet, B., Lambert, W., Garcia, J., Lecomte, G., De Leenheer, A.P., Mazieres, B., Thouvenot, J.P., Arlet, J. Clin. Chim. Acta (1991) [Pubmed]
  24. Abnormal whole-body technetium-99m MDP scintigraphy indicating cortical hyperostosis following long-term administration of prostataglandin E-1 in an infant with cyanotic congenital heart disease. Edeling, C.J., Frederiksen, P.B. Clinical nuclear medicine. (1987) [Pubmed]
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