Disease relevance of thallium

• However, Tl/BMIPP dual SPECT had limited ability to detect minor myocardial infarcts classified as redefined MI [1].
• The present studies investigated the influence of various interventions, designed to simulate the metabolic consequences of ischemia, on thallium-204 uptake and release in cultured myocardial cells [2].
• The sites of decreased accumulation of BMIPP and TI were in good agreement with the sites of wall hypertrophy [3].
• CONCLUSION: The use of Tl uptake indices improves the accuracy of Tl-SPECT in the follow-up of brain tumors [4].

High impact information on thallium

• However, this mAb inhibits agonist-induced thallium (T1+) influx into AcChoR-rich membrane vesicles, as measured on a millisecond time scale by means of a rapid kinetics "stopped-flow/fluorescence quenching" technique [5].
• The present results show that Tl interacts with membranes inducing major alterations in the rheology of the bilayer, which could be partially responsible for the neurotoxic effects of this metal [6].
• One minute after the desired blood pressure and heart rate responses were reached, 2 mCi of Tl were injected and the PH infusion continued until the termination of the test [7].
• In this study, we therefore investigated a group of 15 patients with ARVC using thallium-201 (Tl) single-photon emission tomography (SPECT) and echocardiography including assessment of mitral annular motion with M-mode and pulsed tissue Doppler [8].
• Involvement of K+-ATP-dependent channel in transport of monovalent thallium (Tl+) across the inner membrane of rat liver mitochondria [9].

Anatomical context of thallium

• (4) In EX-TL of RVMI-A group, the right ventricle was visible although the uptake of TL was reduced in the entire right ventricle [10].

Associations of thallium with other chemical compounds

• There are no large studies available to guide the selection of thallium (Tl), methoxyisobutylisonitrile (MIBI) or tetrofosmin (Tf) for myocardial perfusion imaging [11].
• The parameters of OGTT, myocardial scintigraphy (n=58) (thallium-201 (Tl) and iodine-123-beta-methyl-iodophenylpentadecanoic acid (BMIPP)) and left ventriculography (n=24) were compared in the 2 groups after reperfusion (acute phase) and 3-4 weeks after the AMI (chronic phase) [12].

Analytical, diagnostic and therapeutic context of thallium

• Studies were carried out using low concentrations (10 nM to 5 microM) of thallium-204, approximating those likely to be encountered during clinical myocardial scintigraphy [13].
• OBJECTIVE: To assess the use of 201Thallium SPECT and of Thallium (Tl) uptake indices in the detection and follow-up of cerebral tumors [4].
• The proportion of patients with perfusion and metabolic abnormalities was significantly higher in the redefined MI group (Tl defect 36% vs. 4%, odds ratio: 13.5, p<0.001; BMIPP defect 64% vs. 23%, odds ratio: 5.8, p<0.001) [1].
• Early and delayed planar images, obtained at 15 min and 3 h following the intravenous injection of Tl (111 MBq), were examined [14].
• Tl scintigraphy was performed both 2 min after Tl injection and 4 h later, while the results were correlated to coronary angiography findings [7].

References