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Disease relevance of Efrotomycin

  • In contrast, extracts from B. subtilis failed to restore activity in an efrotomycin-inhibited E. coli system [1].
  • A total of 107 Enterococcus strains, 10 Vagococcus fluvialis strains, and 8 Lactococcus garvieae strains were tested for acidification of methyl-alpha-D-glucopyranoside (MGP) and susceptibility to 100-microg efrotomycin (EFRO) disks [2].
  • The susceptibility of 69 clinical isolates of Clostridium difficile from the Minneapolis Veterans Administration Medical Center and 29 C. difficile strains from other hospitals to efrotomycin, ciprofloxacin, and six other antimicrobials was tested in vitro by agar dilution [3].
  • The antibiotic efrotomycin (I), C59H88N2O20, was isolated from cultures of Nocardia lactamdurans as an amorphous yellow powder [4].
  • The influence of efrotomycin administered at the rate of 16 mg/kg of feed in 10 Salmonella typhimurium-inoculated pigs was determined by comparing this group with a group of 10 pigs inoculated with S typhimurium that were given nonmedicated feed [5].

High impact information on Efrotomycin

  • Homologous and heterologous reconstituted systems were used to compare the effects of MDL 62,879 and of efrotomycin, an EF-Tu inhibitor of the kirromycin class, which is inactive against both B. subtilis and E. coli [1].
  • Dominance or resistance to MDL 62,879 and of sensitivity to efrotomycin in heterologous cell-free protein synthesis confirms that inhibition of EF-Tu by the two antibiotics is mediated by different mechanisms of action [1].
  • Six studies involving 700 pigs were conducted in five separate swine research facilities to evaluate weight gain and efficiency of feed utilization in pigs fed the antibiotic efrotomycin [6].
  • Heneicomycin compared favorably with efrotomycin when given subcutaneously or per os against infections with Moraxella bovis and Streptococcus pyogenes [7].
  • EF-Tus from streptococci were significantly less sensitive than EF-Tus from Gram-negative bacteria to both efrotomycin and pulvomycin [8].

Biological context of Efrotomycin


Associations of Efrotomycin with other chemical compounds

  • Sensitivity of elongation factor Tu (EF-Tu) from different bacterial species to the antibiotics efrotomycin, pulvomycin and MDL 62879 [8].

Gene context of Efrotomycin


Analytical, diagnostic and therapeutic context of Efrotomycin


  1. Inhibition of bacterial protein synthesis by elongation-factor-Tu-binding antibiotics MDL 62,879 and efrotomycin. Landini, P., Bandera, M., Goldstein, B.P., Ripamonti, F., Soffientini, A., Islam, K., Denaro, M. Biochem. J. (1992) [Pubmed]
  2. Use of tests for acidification of methyl-alpha-D-glucopyranoside and susceptibility to efrotomycin for differentiation of strains of Enterococcus and some related genera. Carvalho, M.G., Teixeira, L.M., Facklam, R.R. J. Clin. Microbiol. (1998) [Pubmed]
  3. In vitro activity of efrotomycin, ciprofloxacin, and six other antimicrobials against Clostridium difficile. Clabots, C.R., Shanholtzer, C.J., Peterson, L.R., Gerding, D.N. Diagn. Microbiol. Infect. Dis. (1987) [Pubmed]
  4. The structure of efrotomycin. Dewey, R.S., Arison, B.H., Hannah, J., Shih, D.H., Albers-Schönberg, G. J. Antibiot. (1985) [Pubmed]
  5. Effect of efrotomycin in feed on the quantity, duration, and prevalence of shedding and antibacterial susceptibility of Salmonella typhimurium in experimentally infected swine. Jacks, T.M., Frazier, E., Judith, F.R., Olson, G. Am. J. Vet. Res. (1988) [Pubmed]
  6. Effect of efrotomycin on gain and feed efficiency for pigs from weaning until market weight. Foster, A.G., Baker, D.H., Cline, T.R., Cromwell, G.L., Veum, T.L., Alva-Valdes, R., Ericsson, G.F. J. Anim. Sci. (1987) [Pubmed]
  7. Antibacterial activity of heneicomycin. Frost, B.M., Valiant, M.E., Dulaney, E.L. J. Antibiot. (1979) [Pubmed]
  8. Sensitivity of elongation factor Tu (EF-Tu) from different bacterial species to the antibiotics efrotomycin, pulvomycin and MDL 62879. Landini, P., Bandera, M., Soffientini, A., Goldstein, B.P. J. Gen. Microbiol. (1993) [Pubmed]
  9. Lack of cross-resistance between efrotomycin and antibacterial agents used in the therapy of human and animal infections. Jacks, T.M., Frazier, E.G., Abruzzo, G.K., Graham, A.C., Fromtling, R.A. Methods and findings in experimental and clinical pharmacology. (1989) [Pubmed]
  10. Determination of efrotomycin in feeds by high-performance liquid chromatography. Stong, J.D. The Analyst. (1986) [Pubmed]
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