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Chemical Compound Review

Corwin     but-2-enedioic acid; N-[2-[[2-hydroxy-3-(4...

Synonyms: SureCN1651584, AC1O5TMX, HMS1570J08, HMS2097J08, HMS3267G13, ...
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Disease relevance of Xamoterol


Psychiatry related information on Xamoterol

  • The Corwin (1960) scale measuring role conception and role deprivation was compared with a newly devised instrument that measures bureaucratic, professional, and service-traditional role concepts [5].
  • The Corwin Role Conception Scale assessed role conceptions and role deprivation and the Coopersmith Adult Form Self-Esteem Inventory assessed self-esteem [6].
  • Lyme disease risk reduction through the control of the principal tick vector, Ixodes dammini Spielman, Clifford, Piesman & Corwin, has become a major issue facing public health agencies in many endemic states [7].

High impact information on Xamoterol


Biological context of Xamoterol


Anatomical context of Xamoterol

  • The hemodynamic effects of corwin were evaluated in 9 patients with coronary artery disease and without clinical signs of heart failure at rest, during submaximal exercise and during exercise-induced angina pectoris before and after administration of corwin [12].
  • Although the avian ear has a high capacity for sensory regeneration (Oberholtzer & Corwin, 1997; Stone et al., 1998), the role of macrophages in the regenerative process is uncertain [15].
  • Mice captured within an intensely zoonotic site served as host for laboratory-reared larval Ixodes dammini Spielman, Clifford, Piesman, and Corwin, and the resulting nymphal ticks were assayed for evidence of salivary gland infection by the piroplasm [16].
  • Corwin reduced the maximum heart rate during exercise from 162(16) beats/min to 120(9) beats/min and reduced the peak heart rate during ambulatory electrocardiography from 113(11) to 90(6) beats/min consistent with a beta adrenoreceptor antagonist action at higher levels of sympathetic nervous system activity [17].

Gene context of Xamoterol

  • Infestation of the eastern chipmunk, Tamias striatus L., by immature Ixodes dammini Spielman, Clifford, Piesman and Corwin was studied in Castle Rock State Park in northwestern Illinois during June-October 1991 [18].
  • The distributions of Ixodes dammini Spielman, Clifford, Piesman, and Corwin and Lyme disease spirochetes were studied on Fire Island, N.Y. Adult ticks were more common in high-shrub habitats (shrubby vegetation greater than or equal to 1 m high) than in grassy and lowshrub habitats (vegetation less than 1 m) in spring and fall [19].
  • Five km of hiking trails in Castle Rock State Park in Ogle Co., Ill., were drag-sampled for Ixodes dammini Spielman, Clifford, Piesman & Corwin between 15 May and 19 October 1989 [20].

Analytical, diagnostic and therapeutic context of Xamoterol

  • 1. A bicycle exercise test was used to investigate functional capability and haemodynamics in 30 patients with heart failure (13 NYHA Class II, 17 Class III), before and after i.v. xamoterol (Corwin, Carwin, Corwil, Xamtol, ICI 118,587) 0.2 mg kg-1 [21].
  • In a double-blind, random, cross-over study, 14 healthy male volunteers received xamoterol 200 mg (Corwin; C) twice daily or placebo (P) for two seven-day medication periods to investigate effects on physical performance, cardiocirculatory parameters, metabolism and hormone levels during exercise [22].
  • The effect of Corwin, a new oral beta, partial agonist, on the ventricular response to atrial fibrillation was studied in digitalised patients during 24 hour ambulatory electrocardiography and during exercise on a treadmill in a double blind placebo controlled crossover trial [17].


  1. Effects of a cardioselective beta 1 partial agonist (corwin) on left ventricular function and myocardial metabolism in patients with previous myocardial infarction. Rousseau, M.F., Pouleur, H., Vincent, M.F. Am. J. Cardiol. (1983) [Pubmed]
  2. Acute hemodynamic and metabolic effects of ICI 118,587 (Corwin), a selective partial beta 1 agonist, in patients with dilated cardiomyopathy. Bhatia, S.J., Swedberg, K., Chatterjee, K. Am. Heart J. (1986) [Pubmed]
  3. Reduction of nymphal Ixodes dammini (Acari: Ixodidae) in a residential suburban landscape by area application of insecticides. Curran, K.L., Fish, D., Piesman, J. J. Med. Entomol. (1993) [Pubmed]
  4. Borrelia burgdorferi in ticks (Acari: Ixodidae) from coastal Virginia. Levine, J.F., Sonenshine, D.E., Nicholson, W.L., Turner, R.T. J. Med. Entomol. (1991) [Pubmed]
  5. Nurse role conception. Minehan, P.L. Nursing research. (1977) [Pubmed]
  6. Effects of professional development seminars on role conception, role deprivation, and self-esteem of generic baccalaureate students. Lengacher, C.A. NursingConnections. (1994) [Pubmed]
  7. Effectiveness of an aerial application of carbaryl in controlling Ixodes dammini (Acari: Ixodidae) adults in a high-use recreational area in New Jersey. Schulze, T.L., Taylor, G.C., Vasvary, L.M., Simmons, W., Jordan, R.A. J. Med. Entomol. (1992) [Pubmed]
  8. Improvement of left ventricular contractility and relaxation with the beta 1-adrenergic receptor partial agonist xamoterol at rest and during exercise in patients with postinfarction left ventricular dysfunction. A placebo-controlled randomized trial. de Feyter, P.J., Serruys, P.W., Suryapranata, H. Circulation (1990) [Pubmed]
  9. The effect of xamoterol in failing human myocardium. Schwinger, R.H., Böhm, M., Erdmann, E. Eur. Heart J. (1990) [Pubmed]
  10. Hemodynamic effects of Corwin (ICI 118,587), a new cardioselective beta-adenoceptor partial agonist. Detry, J.M., Decoster, P.M., Brasseur, L.A. Eur. Heart J. (1983) [Pubmed]
  11. Critical flicker frequency to red targets as a function of luminance and flux across the human visual field. Raninen, A., Franssila, R., Rovamo, J. Vision Res. (1991) [Pubmed]
  12. Antianginal effects of corwin, a new beta-adrenoceptor partial agonist. Detry, J.M., Decoster, P.M., Buy, J.J., Rousseau, M.F., Brasseur, L.A. Am. J. Cardiol. (1984) [Pubmed]
  13. Hemodynamic effects of ICI 118.587 (Corwin) in patients with mild cardiac failure after myocardial infarction. Svensson, G., Rehnqvist, N., Sjögren, A., Erhardt, L. J. Cardiovasc. Pharmacol. (1985) [Pubmed]
  14. Adaptions in the life cycle of Dermacentor variabilis (Say) and Ixodes dammini (Spielman, Clifford, Piesman, and Corwin) marginal populations (Acari: Ixodidae). McEnroe, W.D. Exp. Appl. Acarol. (1985) [Pubmed]
  15. Immune cytokines and dexamethasone influence sensory regeneration in the avian vestibular periphery. Warchol, M.E. J. Neurocytol. (1999) [Pubmed]
  16. Reservoir competence of white-footed mice for Babesia microti. Telford, S.R., Spielman, A. J. Med. Entomol. (1993) [Pubmed]
  17. Effect of Corwin (ICI 118587) on resting and exercise heart rate and exercise tolerance in digitalised patients with chronic atrial fibrillation. Molajo, A.O., Coupe, M.O., Bennett, D.H. British heart journal. (1984) [Pubmed]
  18. Role of the eastern chipmunk as a host for immature Ixodes dammini (Acari: Ixodidae) in northwestern Illinois. Mannelli, A., Kitron, U., Jones, C.J., Slajchert, T.L. J. Med. Entomol. (1993) [Pubmed]
  19. Habitat distribution of Ixodes dammini (Acari: Ixodidae) an Lyme disease spirochetes on Fire Island, New York. Ginsberg, H.S., Ewing, C.P. J. Med. Entomol. (1989) [Pubmed]
  20. Spatial and temporal distribution of Ixodes dammini (Acari: Ixodidae) in a northwestern Illinois state park. Siegel, J.P., Kitron, U., Bouseman, J.K. J. Med. Entomol. (1991) [Pubmed]
  21. Effects of xamoterol on resting and exercise haemodynamics in patients with chronic heart failure. Virk, S.J., Davies, M.K. British journal of clinical pharmacology. (1989) [Pubmed]
  22. Influence of xamoterol, a partial beta 1-selective agonist, on physical performance capacity and cardiocirculatory, metabolic and hormonal parameters. Kullmer, T., Kindermann, W., Urhausen, A., Hess, M. Eur. J. Clin. Pharmacol. (1988) [Pubmed]
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