Disease relevance of Tuberculostearic acid

• Demonstration of tuberculostearic acid in sputum from patients with pulmonary tuberculosis by selected ion monitoring [1].
• Tuberculostearic acid as a diagnostic marker in tuberculous meningitis [2].
• False-positive tuberculostearic acid tests in cysticercosis [3].
• A novel fatty acid in the mycobacterium genus assigned to a 12-O-(methoxypropanoyl)-12-hydroxystearic acid was the only fatty acid esterifying C-1 of the glycerol residue of the parietal ManLAMs, while the phosphatidyl unit of the cellular ManLAMs showed a large heterogeneity due to a combination of palmitic and tuberculostearic acid [4].
• Diagnosis of tuberculous pleural effusion by the detection of tuberculostearic acid in pleural aspirates [5].

High impact information on Tuberculostearic acid

• Diagnosis of tuberculous meningitis by detection of tuberculostearic acid in cerebrospinal fluid [6].
• Evaluation of polymerase chain reaction, tuberculostearic acid analysis, and direct microscopy for the detection of Mycobacterium tuberculosis in sputum [7].
• Selective procedures for detecting femtomole quantities of tuberculostearic acid in serum and cerebrospinal fluid by frequency-pulsed electron capture gas-liquid chromatography [8].
• Use of these columns improved the reagent cleanup procedure, simplified the derivatization step, permitted increased detection of trace components, such as tuberculostearic acid, in body fluids, and improved the selectivity of the procedure for detection of carboxylic acids [9].
• It was characterized chemotaxonomically as having ll-2,6-diaminopimelic acid in the cell-wall peptidoglycan, MK-9(H(4)) as the predominant menaquinone and C(16 : 0), 10-methyl C(18 : 0) (tuberculostearic acid), C(16 : 0) 2-OH, 10-methyl C(17 : 0) and 10-methyl-C(16 : 0) as the major fatty acids [10].

Biological context of Tuberculostearic acid

• Hydrogenation and oxidation of the resulting (R,S)-10-methyloctadec-7-yn-1-ol gave racemic tuberculostearic acid [11].
• Conversely, tuberculostearic acid induced early cell death [12].

Anatomical context of Tuberculostearic acid

• In corresponding analyses of sputum from eight patients with non-tuberculous pneumonia, tuberculostearic acid was not found [1].
• Tuberculostearic acid in lymph nodes from patients with sarcoidosis [13].

Associations of Tuberculostearic acid with other chemical compounds

• The ratio of tuberculostearic acid to 2-eicosanol was much lower in sputum samples culture positive for mycobacteria than in the corresponding in vitro-grown cultures [14].

Gene context of Tuberculostearic acid

• Simultaneous measurements of adenosine deaminase activity and tuberculostearic acid in pleural effusions for the diagnosis of tuberculous pleuritis [15].
• The third, a modern chemotaxonomical method is based upon the detection of tuberculostearic acid by GC-MS analysis using selected ion monitoring (GC-MS/SIM) [16].

Analytical, diagnostic and therapeutic context of Tuberculostearic acid

• In serial CSF samples from patients with tuberculous meningitis tuberculostearic acid was still present after 8 months of continuous supervised chemotherapy [6].
• OBJECTIVE: To determine whether the detection of tuberculostearic acid (TBSA) in bronchial aspirate and bronchoalveolar lavage specimens is useful for the rapid diagnosis of active pulmonary tuberculosis in patients suspected of having the disease [17].
• A tuberculostearic acid assay in the diagnosis of sputum smear-negative pulmonary tuberculosis. A prospective study of bronchoscopic aspirate and lavage specimens [17].
• The utility of other developing methodologies, such as polymerase chain reaction technology, analysis of body fluids for tuberculostearic acid, and the use of ELISA are also assessed [18].
• Tuberculostearic acid (TBSA), a mycobacterial cell wall constituent, was measured in plasma samples using a highly sensitive high-performance liquid chromatography method [19].

References