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Chemical Compound Review

Acetosol     1,1,2,2-tetrachloroethane

Synonyms: Bonoform, Westron, Cellon, TeCA, CCRIS 578, ...
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Disease relevance of Bonoform


High impact information on Bonoform

  • UV/Vis and CD spectroscopic measurements indicated that, similar to the OPV-PERY-OPV triad molecule, the model compound Ph-PERY-Ph was also present in the aggregated form in solvents such as toluene, chloroform, and tetrachloroethane, and in the molecularly dissolved state in THF [2].
  • Absorbance spectra and CD spectroscopic measurements of the triad molecule indicated the formation of aggregates in solvents such as toluene, chloroform, and tetrachloroethane, whereas it was present in the molecularly dissolved state in THF [2].
  • It is proposed that, although the cytochrome P-450 dependent metabolism of the chloroethanes in microsomes can greatly exceed that in nuclei, the metabolism of 1,2-dichloroethane and 1,1,2,2-tetrachloroethane by nuclear cytochrome P-450 may in part mediate the mutagenicity and carcinogenicity of parent compounds [3].
  • Cytochrome P-450-dependent metabolism of 1,1,2,2-tetrachloroethane to dichloroacetic acid in vitro [4].
  • The performance of the method has been tested on two known substrates of the wild-type cytochrome P450 BM3, arachidonic (AA) and lauric (LA) acids, and two substrates with environmental significance, the anionic surfactant sodium dodecyl sulfate (SDS), and the solvent 1,1,2,2-tetrachloroethane (TCE) [5].

Biological context of Bonoform


Anatomical context of Bonoform


Associations of Bonoform with other chemical compounds


Gene context of Bonoform


  1. 1,1,2,2-Tetrachloroethane-induced early decrease of dolichol levels in rat liver microsomes and Golgi apparatus. Cottalasso, D., Bellocchio, A., Domenicotti, C., Dapino, D., Pronzato, M.A., Nanni, G. J. Toxicol. Environ. Health Part A (1998) [Pubmed]
  2. Synthesis, optical properties, and aggregation behavior of a triad system based on perylene and oligo(p-phenylene vinylene) units. Syamakumari, A., Schenning, A.P., Meijer, E.W. Chemistry (Weinheim an der Bergstrasse, Germany) (2002) [Pubmed]
  3. Metabolism of chloroethanes by rat liver nuclear cytochrome P-450. Casciola, L.A., Ivanetich, K.M. Carcinogenesis (1984) [Pubmed]
  4. Cytochrome P-450-dependent metabolism of 1,1,2,2-tetrachloroethane to dichloroacetic acid in vitro. Halpert, J., Neal, R.A. Biochem. Pharmacol. (1981) [Pubmed]
  5. High throughput assay for cytochrome P450 BM3 for screening libraries of substrates and combinatorial mutants. Tsotsou, G.E., Cass, A.E., Gilardi, G. Biosensors & bioelectronics. (2002) [Pubmed]
  6. Anaerobic bioremediation of groundwater containing a mixture of 1,1,2,2-tetrachloroethane and chloroethenes. Aulenta, F., Potalivo, M., Majone, M., Papini, M.P., Tandoi, V. Biodegradation (2006) [Pubmed]
  7. In vitro transformation of BALB/c 3T3 cells by 1,1,2,2-tetrachloroethane. Colacci, A., Perocco, P., Vaccari, M., Mazzullo, M., Albini, A., Parodi, S., Taningher, M., Grilli, S. Jpn. J. Cancer Res. (1990) [Pubmed]
  8. Inter- and intramolecular deuterium isotope effects on the cytochrome P-450-catalyzed oxidative dehalogenation of 1,1,2,2-tetrachloroethane. Hales, D.B., Ho, B., Thompson, J.A. Biochem. Biophys. Res. Commun. (1987) [Pubmed]
  9. Treatment of experimental imipramine and desipramine poisoning in the rat. Rauws, A.G., Olling, M. Arch. Toxicol. (1976) [Pubmed]
  10. NTP technical report on the toxicity studies of 1,1,2,2-tetrachloroethane (CAS No. 79-34-5) administered in microcapsules in feed to F344/N rats and B6C3F1 mice. Chan, P.C. Toxicity report series. (2004) [Pubmed]
  11. The covalent binding of 1,1,2,2-tetrachloroethane to macromolecules of rat and mouse organs. Colacci, A., Grilli, S., Lattanzi, G., Prodi, G., Paola Turina, M., Cantelli Forti, G., Mazzullo, M. Teratog., Carcinog. Mutagen. (1987) [Pubmed]
  12. Analyses of volatile C2 haloethanes and haloethenes in tissues: sample preparation and extraction. Chen, X.M., Dallas, C.E., Muralidhara, S., Srivatsan, V., Bruckner, J.V. J. Chromatogr. (1993) [Pubmed]
  13. A physiologically based toxicokinetic model for dermal absorption of organic chemicals by fish. Nichols, J.W., McKim, J.M., Lien, G.J., Hoffman, A.D., Bertelsen, S.L., Elonen, C.M. Fundamental and applied toxicology : official journal of the Society of Toxicology. (1996) [Pubmed]
  14. On the hepatotoxicity of 1,1,2,2-tetrachloroethane. Paolini, M., Sapigni, E., Mesirca, R., Pedulli, G.F., Corongiu, F.P., Dessi, M.A., Cantelli-Forti, G. Toxicology (1992) [Pubmed]
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