Disease relevance of PENTACHLOROETHANE

• Six of nine chemicals induced chromosomal aberrations; bromodichloromethane, chlorendic acid and isophorone induced structural aberrations, and chlorodibromomethane, pentachloroethane and 1,1,1,2-tetrachloroethane induced numerical aberrations (polyploidy) [1].
• Due to high toxicity, 1,1,2,2-tetrachloroethane and pentachloroethane were given at a dose level equivalent to one quarter of that of CCl4 and the other chlorohydrocarbons (i.e. 2-6 mmol/kg) [2].

High impact information on PENTACHLOROETHANE

• However, pentachloroethane and tetrachloroethylene, the main products of the metabolism of hexachloroethane in sheep, were potent spasmogens in preparations of Fasciola hepatica [3].
• Loida (1994, PhD Thesis, University of Illinois at Urbana-Champaign, IL) and S.G.Sligar (personal communication) have observed recently that an active-site variant of cytochrome P450cam (F87W) dechlorinates pentachloroethane approximately three times faster than the wild-type enzyme [4].
• Exposure to 1500, 150, or 15 micrograms PCE/liter for 48 hr resulted in corresponding changes in the magnitude of blood concentrations without any change in uptake kinetics [5].
• Chlorinated olefins were formed in vitro from hexachloroethane, pentachloroethane, and 1,1,1,2-tetrachloroethane by phenobarbital-induced rat liver microsomes [6].
• Short-term experiments were conducted to investigate the effect of a commercial Fe and an iron-bearing clay mineral, ferruginuous smectite (SWa-1), on the degradation of pentachloroethane (PCA) [7].

Biological context of PENTACHLOROETHANE

• Metabolic activation and covalent binding to nucleic acids of pentachloroethane as short-term test of genotoxicity [8].

Associations of PENTACHLOROETHANE with other chemical compounds

• The mean dermal fluxes for TCE, PCE, and HCE ranged from 1.4 to 2.8, 1.8 to 3.6, and 1.4 to 3.2% of the total flux (branchial plus dermal) in rainbow trout and channel catfish, respectively [9].
• Tetrachloroethane (TTCE), pentachloroethane (PCE), and hexachloroethane (HCE) were tested in diploid strain (D7) of the yeast Saccharomyces cerevisiae in suspension test with and without mammalian metabolic activation (S9) [10].
• The main products of the in vitro metabolism of hexa- and pentachloroethane were tetra- and trichloroethene, respectively [11].

References