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Chemical Compound Review

Bromdian     2,6-dibromo-4-[2-(3,5- dibromo-4-hydroxy...

Synonyms: Tetrabromodian, SureCN18647, ARONIS002155, CHEMBL184450, CCRIS 6274, ...
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Disease relevance of Tetrabromodian


High impact information on Tetrabromodian


Biological context of Tetrabromodian


Anatomical context of Tetrabromodian


Associations of Tetrabromodian with other chemical compounds

  • Effects of the brominated flame retardants hexabromocyclododecane (HBCDD), and tetrabromobisphenol A (TBBPA), on hepatic enzymes and other biomarkers in juvenile rainbow trout and feral eelpout [11].
  • For TBBPA and TBP 5-d effective median concentration (EC50) values for inhibition of the larval development rate were 125 and 810 microg/L, respectively, whereas the PBDEs were much more potent with 5-d EC50 in the low microg/L range (1.2 microg/L for BDE-100; 4.2 microg/L for BDE-99; 13 microg/L for BDE-28; and 13 microg/L for BDE-47) [12].


  1. In vitro effects of brominated flame retardants and metabolites on CYP17 catalytic activity: A novel mechanism of action? Cant??n, R.F., Sanderson, J.T., Nijmeijer, S., Bergman, A., Letcher, R.J., van den Berg, M. Toxicol. Appl. Pharmacol. (2006) [Pubmed]
  2. Metabolism, excretion and distribution of the flame retardant tetrabromobisphenol-A in conventional and bile-duct cannulated rats. Hakk, H., Larsen, G., Bergman, A., Orn, U. Xenobiotica (2000) [Pubmed]
  3. Toxic effects of brominated flame retardants in man and in wildlife. Darnerud, P.O. Environment international. (2003) [Pubmed]
  4. The effect of brominated flame retardants on neurotransmitter uptake into rat brain synaptosomes and vesicles. Mariussen, E., Fonnum, F. Neurochem. Int. (2003) [Pubmed]
  5. In vitro and in vivo analysis of the thyroid system-disrupting activities of brominated phenolic and phenol compounds in Xenopus laevis. Kudo, Y., Yamauchi, K., Fukazawa, H., Terao, Y. Toxicol. Sci. (2006) [Pubmed]
  6. The effect of a brominated flame retardant, tetrabromobisphenol-A, on free radical formation in human neutrophil granulocytes: the involvement of the MAP kinase pathway and protein kinase C. Reistad, T., Mariussen, E., Fonnum, F. Toxicol. Sci. (2005) [Pubmed]
  7. Anaerobic degradation of brominated flame retardants in sewage sludge. Gerecke, A.C., Giger, W., Hartmann, P.C., Heeb, N.V., Kohler, H.P., Schmid, P., Zennegg, M., Kohler, M. Chemosphere (2006) [Pubmed]
  8. Estrogen-like properties of brominated analogs of bisphenol A in the MCF-7 human breast cancer cell line. Samuelsen, M., Olsen, C., Holme, J.A., Meussen-Elholm, E., Bergmann, A., Hongslo, J.K. Cell Biol. Toxicol. (2001) [Pubmed]
  9. Exposure to tetrabromobisphenol-A alters TH-associated gene expression and tadpole metamorphosis in the Pacific tree frog Pseudacris regilla. Veldhoen, N., Boggs, A., Walzak, K., Helbing, C.C. Aquat. Toxicol. (2006) [Pubmed]
  10. Effects of the brominated flame retardant tetrabromobisphenol-A (TBBPA) on cell signaling and function of Mytilus hemocytes: involvement of MAP kinases and protein kinase C. Canesi, L., Lorusso, L.C., Ciacci, C., Betti, M., Gallo, G. Aquat. Toxicol. (2005) [Pubmed]
  11. Effects of the brominated flame retardants hexabromocyclododecane (HBCDD), and tetrabromobisphenol A (TBBPA), on hepatic enzymes and other biomarkers in juvenile rainbow trout and feral eelpout. Ronisz, D., Finne, E.F., Karlsson, H., Förlin, L. Aquat. Toxicol. (2004) [Pubmed]
  12. Brominated flame retardants: activities in a crustacean development test and in an ecdysteroid screening assay. Wollenberger, L., Dinan, L., Breitholtz, M. Environ. Toxicol. Chem. (2005) [Pubmed]
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