Disease relevance of Mytilus

• The present study examined the effects of three heavy metals on the acetylcholine (ACh) contracture and Ca++ kinetics of the anterior byssus retractor muscle of Mytilus edulis [1].
• Enkephalin-like immunoreactivity in the pedal ganglion of Mytilus edulis (Bivalvia) and its proximity to dopamine-containing structures [2].
• Relationship between domoic acid levels in the blue mussel (Mytilus edulis) and toxicity in mice [3].
• The change in the content of cyclic GMP, cyclic AMP, ATP, ADP, AMP and fructose-2,6-bisphosphate that occurred in the mantle of the mussel Mytilus galloprovincialis Lmk when specimens of this mollusk were subjected to a hypoxia/anoxia situation were assessed [4].
• Absence of histopathological response to cadmium in gill and digestive diverticula of the mussel, Mytilus edulis [5].

High impact information on Mytilus

• In contrast to fish, blue mussels (Mytilus edulus) collected during the DA outbreak contained no DA or only trace amounts [6].
• In invertebrate organisms such as the mollusc Mytilus edulis, Met-enkephalin triggers inflammatory responses by inducing morphological changes, directed migration and aggregation of haemocytes [7].
• Opioid inhibition of dopamine release from nervous tissue of Mytilus edulis and Octopus bimaculatus [8].
• Treatment of the mussel Mytilus edulis with 6-hydroxydopamine or with alpha-methyl-p-tyrosine decreased dopamine and increased serotonin in the nervous system [9].
• Amino acid analysis of mfp-1 extracted from successive foot sections of Mytilus galloprovincialis reveals a post-translationally mediated gradient with highest Dopa levels present in mfp-1 from the accessory gland near the tip of the foot decreasing gradually toward the base [10].

Chemical compound and disease context of Mytilus

• Replacement of calcium in artificial sea water (ASW) by nickel causes a loss of calcium at a single exponential rate (tau = 23.2 min) and the loss of contracture response to acetylcholine (ACh) in the anterior byssus retractor muscle of Mytilus edulis L [11].
• Toxicity of domoic acid in the marine mussel Mytilus edulis [12].
• Toxicity of tributyltin in the marine mollusc Mytilus edulis [13].
• The major toxicity associated with extracts of Mytilus edulis and Mya arenaria collected during a 1972 red tide off Hampton, New Hampshire, was due to the presence of GTX1/GTX4, with some activity associated with neoSTX, GTX2 and GTX3 [14].
• The effects of dietary restriction on the toxicity of copper and the polycyclic aromatic hydrocarbon phenanthrene have been investigated in the common marine mussel Mytilus edulis [15].

Biological context of Mytilus

• Innate immunity. Isolation of several cysteine-rich antimicrobial peptides from the blood of a mollusc, Mytilus edulis [16].
• The data from this study, together with data from Mytilus edulis and Metridium senile on temperature-dependent kinetic variation among PGI allozymes, form a consistent picture of natural selection influencing the clinal variation of alleles at this locus in these three phylogenetically distant organisms [17].
• To test hypotheses of the molecular evolution of both mtDNA genomes, 50 nucleotide sequences were obtained for 396 bp of the COIII gene of European populations of Mytilus edulis and the Atlantic and Mediterranean forms of M. galloprovincialis [18].
• Analysis of promoter regions shows clear homologies among Mytilus H1 genes, sea urchin H1 genes, and vertebrate differentiation-specific H1 subtypes (H5 and H1(o)), all having an H4 box motif in common [19].
• In this work we provide evidence for a polyadenylation signature in the Mytilus "orphon" H1 genes similar to the polyadenylation characteristic of RI H1 genes [20].

Anatomical context of Mytilus

• An in vitro preparation from the pedal ganglia of the marine bivalve, Mytilus edulis, was used to examine the modulation of transmitter release by adenosine and its analogs from invertebrate nervous tissue [21].
• The present report demonstrates that both mouse thymocytes and Mytilus edulis hemocytes contain a novel type of dopamine receptor [22].
• Serotonin and dopamine content in the central nervous system of Mytilus edulis (Bivalvia) was assayed fluorometrically [23].
• 1. Met-enkephalin is degraded by peptidases present in the hemolymph fluid and hemocyte membrane suspension of Mytilus edulis [24].
• The lateral ciliated gill epithelium of Mytilus edulis was denervated physically and chemically with 5,6-dihydroxytryptamine [25].

Associations of Mytilus with chemical compounds

• Isolation and characterization of the carbon-phosphorus bond-forming enzyme phosphoenolpyruvate mutase from the mollusk Mytilus edulis [26].
• Mfp-1 (Mytilus foot protein-1) is a conspicuous component of the protective outer cuticle of byssal threads given its high 3,4-dihydroxyphenylalanine (Dopa) content at 10-15 mol % [10].
• Purification and characterization of hydroxyindole oxidase from the gills of Mytilus edulis [27].
• Evidence for a repeating 3,4-dihydroxyphenylalanine- and hydroxyproline-containing decapeptide in the adhesive protein of the mussel, Mytilus edulis L [28].
• Along with proteins of the histone H1 class, the protein also shows cross-reactivity and sequence identity, in its NH2-terminal region, with the major protamine-like protein component of Mytilus sperm: PL-III (phi 1), of smaller molecular mass [29].

Gene context of Mytilus

• 3. Both human and Mytilus immunocytes appear to have specific CRF receptors [30].
• Furthermore, the induction of IL-1 by opioids has also been identified in the invertebrate Mytilus, indicating the evolutionary conservation of this relationship (137) [31].
• Tyrosine kinase-mediated cell signalling in the activation of Mytilus hemocytes: possible role of STAT-like proteins [32].
• Multi-drug resistance (MDR) in MCF7 breast cancer cells and multi-xenobiotic resistance (MXR) in mussel (Mytilus edulis) blood cells (MBC) are well known mechanisms that contribute to the decrease in intracellular concentrations of many unrelated but cytotoxic compounds [33].
• We show that Mytilus hemocytes respond to LPS in a fashion similar to vertebrate monocytes and macrophages and that these responses are inhibited by antibodies to TNF and/or IL-1 [34].

Analytical, diagnostic and therapeutic context of Mytilus

• Measurement of adenosine 3',5'-cyclic monophosphate and guanosine 3', 5'-cyclic monophosphate in mussel (Mytilus galloprovincialis lmk.) by high-performance liquid chromatography with diode array detection [35].
• Epithelial cell renewal in mussel ( Mytilus galloprovincialis, Lmk) digestive gland and stomach was investigated by bromodeoxyuridine (BrdU) immunohistochemistry [36].
• Supercritical fluid extraction (SFE) was compared to traditional Soxhlet extraction for the determination of polychlorinated biphenyl congeners in three standard reference materials: SRM 1941a (Organics in Marine Sediment), SRM 1944 (New York/New Jersey Waterway Sediment) and SRM 2974 [Organics in Mussel Tissue (Mytilus edulis) (Freeze-Dried)] [37].
• Monitoring of eastern blue mussels (Mytilus edulis), contaminated with domoic acid, involved mouse bioassays and quantitative analysis using HPLC [3].
• The validity of two HPLC methods and a colorimetric PP2A assay related to the mouse bioassay in quantification of diarrhetic toxins in blue mussels (Mytilus edulis) [38].

References