Disease relevance of Khinaldin

• Gene cluster of Arthrobacter ilicis Ru61a involved in the degradation of quinaldine to anthranilate: characterization and functional expression of the quinaldine 4-oxidase qoxLMS genes [1].
• Another pseudomonad, Pseudomonas sp. strain MQP, was isolated that could degrade 2-methylquinoline [2].
• An analogous hydroxylation in para-position relative to the N-heteroatom was only recently described for quinaldine 4-oxidoreductase (de Beyer & Lingens, 1993, Biol. Chem. Hoppe-Seyler 374, 101-110) and for quinaldic acid 4-oxidoreductase from Serratia marcescens 2CC-1 (Fetzner & Lingens, 1993, Biol. Chem. Hoppe-Seyler 374, 363-376) [3].

High impact information on Khinaldin

• Quinaldine 4-oxidase (Qox), which catalyzes the hydroxylation of quinaldine to 1H-4-oxoquinaldine, is a heterotrimeric (LMS)2 molybdo-iron/sulfur flavoprotein belonging to the xanthine oxidase family [4].
• Although a minor reduction of the glutamine substituted variant QoxLE736Q by quinaldine occurred, its activity was below detection, indicating that the carboxylate group of E736 is crucial for catalysis [4].
• Spectroscopic and Biochemical Studies on Protein Variants of Quinaldine 4-Oxidase: Role of E736 in Catalysis and Effects of Serine Ligands on the FeSI and FeSII Clusters [4].
• For three prokaryotic enzymes of the xanthine oxidase family, namely quinoline 2-oxidoreductase, quinaldine 4-oxidase, and isoquinoline 1-oxidoreductase, the electron transfer centers were investigated by electron paramagnetic resonance [5].
• All of the quinoline- and methylquinoline-degrading strains have multiple plasmids including a common 250-kilobase plasmid [2].

Anatomical context of Khinaldin

• Additionally, 10 volatiles (two aldehydes, five ketones, benzothiazole, 2-methylquinoline, and 4-methylquinazoline), not previously identified, were found in ferret anal gland secretions [6].
• In the present work, four anaesthetics that are used in aquaculture, MS222 (0 19 mM), benzocaine (0.21 mM), 2-phenoxyethanol (16 mM) and quinaldine sulphate (0.083 mM), were tested in order to observe their effects on the gilthead seabream (Sparus aurata L.) innate immune system [7].

Associations of Khinaldin with other chemical compounds

• A method for the measurement of quinaldine and 2-hydroxymethylquinoline using gas chromatography is described [8].

Analytical, diagnostic and therapeutic context of Khinaldin

• Five other quinaldine-degrading Gram-positive strains were isolated from soil samples; 16S rDNA sequence analysis suggested the closest relationship to different Arthrobacter species [9].

References