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Chemical Compound Review

o-Cresol Red     4-[9-(4-hydroxy-3-methyl- phenyl)-7,7-dioxo...

Synonyms: Cresol red, NSC-7224, NSC7224, AC-18340, NSC 7224, ...
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Disease relevance of NSC7224

  • We studied the kinetics of proton uptake and release by photoactive yellow protein (PYP) from Ectothiorhodospira halophila in wild type and the E46Q and E46A mutants by transient absorption spectroscopy with the pH-indicator dyes bromocresol purple or cresol red in unbuffered solution [1].

Psychiatry related information on NSC7224


High impact information on NSC7224

  • Simultaneous recordings of JDIS and the extravesicular pH from cresol-red absorbance changes, suggest that protons are the main current-carrying species across the chromatophore membrane at high values of delta psi in the presence and absence of Fo-ATPase inhibitor [3].
  • The histidine-containing culture supernatants of the A. baumannii and V. anguillarum strains showed an increase of about two units of pH, turned purple upon the addition of cresol red, and contained high amounts of ammonia [4].
  • The phenolphthlalein CO2 methodology, showing improved flow parameters over those for the cresol red procedure is adapted for the Flame IV system [5].
  • An additional interaction correction variable designated as Beta (beta) is described and applied to the regenerated peaks of the cresol red CO2 procedure [5].
  • Phenol red and/or cresol red as pH sensitive dyes were immobilized on the surface of the hetero-core portion by using sol-gel method, and the pH change detection was performed by immersing the hetero-core portion into the solution [6].

Anatomical context of NSC7224


Associations of NSC7224 with other chemical compounds

  • A new optical CO(2) sensor based on the luminescence intensity change of the europium(III) complex tris(thenoyltrifluoroacetonato) europium(III) dihydrate ([Eu(tta)(3)]) caused by the absorption change of various pH indicators-thymol blue, phenol red, or cresol red-with CO(2) was developed and its CO(2) sensing properties were investigated [2].
  • 2. The H+ efflux following rapid H+ binding after a flash, measured from the colour change of added cresol red, shows very similar kinetics to the carotenoid shift decay suggesting that the dissipation of the electric potential decay is a consequence of the H+ efflux [9].
  • Modification of IgH PCR clonal analysis by the addition of sucrose and cresol red directly to PCR reaction mixes [10].
  • Determination of the acid dissociation constant of bromocresol green and cresol red in water/AOT/isooctane reverse micelles by multiple linear regression and extended principal component analysis [11].

Analytical, diagnostic and therapeutic context of NSC7224

  • Theoretical and practical approaches show that, in multicuvettes, a between-well temperature resolution of < 0.05 degrees C can be achieved by multiwavelength photometry with use of the Tris/cresol red indicator system [12].
  • The optimized conditions of the FI system were as follows: the flow rate of each carrier, reaction solution (H2SO4) and receptor solution (Cresol Red, pH 8.9) was 0.25 ml min(-1), the sample size was 0.1 ml and the concentration of H2SO4 in the reaction solution was 0.09 M [13].


  1. Kinetics of proton uptake and dye binding by photoactive yellow protein in wild type and in the E46Q and E46A mutants. Borucki, B., Devanathan, S., Otto, H., Cusanovich, M.A., Tollin, G., Heyn, M.P. Biochemistry (2002) [Pubmed]
  2. Optical sensor for carbon dioxide combining colorimetric change of a pH indicator and a reference luminescent dye. Nakamura, N., Amao, Y. Analytical and bioanalytical chemistry. (2003) [Pubmed]
  3. Changes in membrane ionic conductance, but not changes in slip, can account for the non-linear dependence of the electrochemical proton gradient upon the electron-transport rate in chromatophores. Cotton, N.P., Clark, A.J., Jackson, J.B. Eur. J. Biochem. (1984) [Pubmed]
  4. Comparison of differential plating media and two chromatography techniques for the detection of histamine production in bacteria. Actis, L.A., Smoot, J.C., Barancin, C.E., Findlay, R.H. J. Microbiol. Methods (1999) [Pubmed]
  5. Application of curve regeneration to the determination of electrolytes by the Flame IV Auto-Analyser using a mini-computer. Jacklyn, C.L., MacAulay, M.A., Mathers, J.M., Munro, C.A., Kriz, C.D. Clin. Biochem. (1978) [Pubmed]
  6. A hetero-core structured fiber optic pH sensor. Seki, A., Katakura, H., Kai, T., Iga, M., Watanabe, K. Anal. Chim. Acta (2007) [Pubmed]
  7. Effect of root canal filling materials containing calcium hydroxide on the alkalinity of root dentin. Staehle, H.J., Spiess, V., Heinecke, A., Müller, H.P. Endodontics & dental traumatology. (1995) [Pubmed]
  8. Effect of the lipid phase transition on the kinetics of H+/OH- diffusion across phosphatidic acid bilayers. Elamrani, K., Blume, A. Biochim. Biophys. Acta (1983) [Pubmed]
  9. Electrical potential changes, H+ translocation and phosphorylation induced by short flash excitation in Rhodopseudomonas sphaeroides chromatophores. Saphon, S., Jackson, J.B., Witt, H.T. Biochim. Biophys. Acta (1975) [Pubmed]
  10. Modification of IgH PCR clonal analysis by the addition of sucrose and cresol red directly to PCR reaction mixes. Hodges, E., Boddy, S.M., Thomas, S., Smith, J.L. MP, Mol. Pathol. (1997) [Pubmed]
  11. Determination of the acid dissociation constant of bromocresol green and cresol red in water/AOT/isooctane reverse micelles by multiple linear regression and extended principal component analysis. Caselli, M., Mangone, A., Paolillo, P., Traini, A. Annali di chimica. (2002) [Pubmed]
  12. Multiwavelength photometry of thermochromic indicator solutions for temperature determination in multicuvettes. Schilling, K., Cumme, G.A., Hoffmann-Blume, E., Hoppe, H., Horn, A. Clin. Chem. (1993) [Pubmed]
  13. Monitoring the removal of carbonate from alkali metal hydroxide solutions using gas diffusion flow injection. Wei, Y., Oshima, M., Motomizu, S. The Analyst. (2002) [Pubmed]
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