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Chemical Compound Review

PubChem14587     4-tert-butylbenzene-1,2-diol

Synonyms: Synox TBC, SureCN50705, CHEMBL220845, NSC-5310, CCRIS 3332, ...
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Disease relevance of p-tert-Butyl catechol


High impact information on p-tert-Butyl catechol


Biological context of p-tert-Butyl catechol


Anatomical context of p-tert-Butyl catechol


Associations of p-tert-Butyl catechol with other chemical compounds


Gene context of p-tert-Butyl catechol


Analytical, diagnostic and therapeutic context of p-tert-Butyl catechol

  • The absorption, distribution, metabolism, and excretion of p-tert-butylcatechol following intravenous injection, gavage dosing, or dermal application were determined in male F344/N rats and B6C3F1 mice [1].
  • In HPLC analysis of the oxidation 4-tert-butylcatechol and the phenylhydrazide of Boc-tryptophan only the N-protected amino acid and 4-tert-butyl-o-benzoquinone were detected as final products [18].


  1. NTP technical report on the toxicity studies of p-tert-butylcatechol (CAS No. 98-29-3) administered in feed to F344/N rats and B6C3F1 mice. Dunnick, J. Toxicity report series. (2002) [Pubmed]
  2. Promotion by dihydroxybenzene derivatives of N-methyl-N'-nitro-N-nitrosoguanidine-induced F344 rat forestomach and glandular stomach carcinogenesis. Hirose, M., Yamaguchi, S., Fukushima, S., Hasegawa, R., Takahashi, S., Ito, N. Cancer Res. (1989) [Pubmed]
  3. Stopped-flow and steady-state study of the diphenolase activity of mushroom tyrosinase. Rodríguez-López, J.N., Fenoll, L.G., García-Ruiz, P.A., Varón, R., Tudela, J., Thorneley, R.N., García-Cánovas, F. Biochemistry (2000) [Pubmed]
  4. The effect of substrate partitioning on the kinetics of enzymes acting in reverse micelles. Bru, R., Sánchez-Ferrer, A., García-Carmona, F. Biochem. J. (1990) [Pubmed]
  5. Tyrosinase-mediated formation of a reactive quinone from the depigmenting agents, 4-tert-butylphenol and 4-tert-butylcatechol. Thörneby-Andersson, K., Sterner, O., Hansson, C. Pigment Cell Res. (2000) [Pubmed]
  6. Metabolism and disposition of 4-t-butylcatechol in rats and mice. Black, S.R., Mathews, J.M. Drug Metab. Dispos. (2000) [Pubmed]
  7. Contact allergy to the monomers of p-tert-butylphenol-formaldehyde resin in the guinea pig. Zimerson, E., Bruze, M. Contact Derm. (1998) [Pubmed]
  8. Polymeric enzyme mimics: catalytic activity of ribose-containing polymers for a phosphate substrate. Han, M.J., Yoo, K.S., Kim, Y.H., Chang, J.Y. Org. Biomol. Chem. (2003) [Pubmed]
  9. Hydrogen peroxide-dependent 4-t-butylphenol hydroxylation by tyrosinase--a new catalytic activity. Jiménez, M., García-Carmona, F. Biochim. Biophys. Acta (1996) [Pubmed]
  10. Oxidation of 4-tert-butylcatechol and dopamine by hydrogen peroxide catalysed by horseradish peroxidase. García-Moreno, M., Moreno-Conesa, M., Rodríguez-López, J.N., García-Cánovas, F., Varón, R. Biol. Chem. (1999) [Pubmed]
  11. Hydroperoxidase activity of lipoxygenase in the presence of cyclodextrins. Núñez-Delicado, E., Sojo, M.M., Sánchez-Ferrer, A., García-Carmona, F. Arch. Biochem. Biophys. (1999) [Pubmed]
  12. Calibration of a Clark-Type oxygen electrode by tyrosinase-catalyzed oxidation of 4-tert-butylcatechol. Rodriguez-López, J.N., Ros-Martínez, J.R., Varón, R., García-Cánovas, F. Anal. Biochem. (1992) [Pubmed]
  13. Enzymatic and spectroscopic studies on the activation or inhibition effects by substituted phenolic compounds in the oxidation of aryldiamines and catechols catalyzed by Rhus vernicifera laccase. Casella, L., Gullotti, M., Monzani, E., Santagostini, L., Zoppellaro, G., Sakurai, T. J. Inorg. Biochem. (2006) [Pubmed]
  14. Purification and properties of a catechol oxidase from blood cells of the ascidian Pyura stolonifera. Watters, D., Ross, I., McEwan, M., Lavin, M. Mol. Marine Biol. Biotechnol. (1993) [Pubmed]
  15. Reversible sodium dodecyl sulfate activation of latent peach polyphenol oxidase by cyclodextrins. Laveda, F., Núñez-Delicado, E., García-Carmona, F., Sánchez-Ferrer, A. Arch. Biochem. Biophys. (2000) [Pubmed]
  16. Inhibition of tyrosinase activity by 4-tert-butylcatechol and other depigmenting agents. Usami, Y., Landau, A.B., Fukuyama, K., Gellin, G.A. Journal of toxicology and environmental health. (1980) [Pubmed]
  17. Inhibition of peroxidase-catalyzed oxidation of 3,3 ,5,5 -tetramethylbenzidine by aminophenols. Naumchik, I.V., Karasyova, E.I., Metelitza, D.I., Edimecheva, I.P., Sorokin, V.L., Shadyro, O.I. Biochemistry Mosc. (2005) [Pubmed]
  18. Indirect oxidation of amino acid phenylhydrazides by mushroom tyrosinase. Gasowska, B., Frackowiak, B., Wojtasek, H. Biochim. Biophys. Acta (2006) [Pubmed]
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