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Chemical Compound Review

Benzedrex     1-cyclohexyl-N-methyl-propan- 2-amine

Synonyms: Dristan, Obesin, Propilesedrina, Propylhexedrin, CHP-Depot, ...
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Disease relevance of Propylhexedrine


Psychiatry related information on Propylhexedrine


High impact information on Propylhexedrine


Chemical compound and disease context of Propylhexedrine


Biological context of Propylhexedrine


Anatomical context of Propylhexedrine


Analytical, diagnostic and therapeutic context of Propylhexedrine

  • Abuse does not occur by nasal inhalation; however, a small amount of abuse of the propylhexedrine containing nasal inhalers occurs by oral ingestion of the contents of the inhaler or by intravenous injection [4].
  • Because the actual constituents of the injected material prepared from the inhalers were not established, solutions were prepared from Benzedrex Inhalers according to the formula provided by one of the patients [9].


  1. Intravenous propylhexedrine and sudden death. White, L., DiMaio, V.J. N. Engl. J. Med. (1977) [Pubmed]
  2. Propylhexedrine-induced left ventricular dysfunction. Croft, C.H., Firth, B.G., Hillis, L.D. Ann. Intern. Med. (1982) [Pubmed]
  3. Intravenous prophylhexedrine (Benzedrex) abuse and sudden death. Anderson, R.J., Garza, H.R., Garriott, J.C., Dimaio, V. Am. J. Med. (1979) [Pubmed]
  4. Propylhexdrine. Wesson, D.R. Drug and alcohol dependence. (1986) [Pubmed]
  5. Intravenous abuse of propylhexedrine (Benzedrex) and the risk of brainstem dysfunction in young adults. Fornazzari, L., Carlen, P.L., Kapur, B.M. The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques. (1986) [Pubmed]
  6. Pulmonary hypertension associated with long-term inhalation of "crank" methamphetamine. Schaiberger, P.H., Kennedy, T.C., Miller, F.C., Gal, J., Petty, T.L. Chest (1993) [Pubmed]
  7. Pharmacokinetics of phenobarbital and propylhexedrine after administration of barbexaclone in the mouse. Iven, H., Feldbusch, E. Naunyn Schmiedebergs Arch. Pharmacol. (1983) [Pubmed]
  8. Induction of hyperphagia in rats by intracerebroventricular infusion of sodium pentobarbital. A method for testing anorexigenic compounds. Kaufmann, S.H., Hofmann, H.P., Kreiskott, H. Arzneimittel-Forschung. (1981) [Pubmed]
  9. Tissue injuries associated with parenteral propylhexedrine abuse. Mancusi-Ungaro, H.R., Decker, W.J., Forshan, V.R., Blackwell, S.J., Lewis, S.R. J. Toxicol. Clin. Toxicol. (1983) [Pubmed]
  10. Comparative kinetics of phenobarbital after administration of the acid and the propylhexedrine salt (barbexaclone). Perucca, E., Grimaldi, R., Ruberto, G., Gelmi, C., Trimarchi, F., Crema, A. Eur. J. Clin. Pharmacol. (1986) [Pubmed]
  11. Ischemic injury of the hand from intra-arterial propylhexedrine injection. Covey, D.C., Nossaman, B.D., Albright, J.A. The Journal of hand surgery. (1988) [Pubmed]
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