Disease relevance of Propylhexedrine

• Intravenous propylhexedrine and sudden death [1].
• Propylhexedrine-induced left ventricular dysfunction [2].
• Right ventricular hypertrophy was present in nine of the 12 subjects who died of intravenous propylhexedrine abuse [3].
• Intravenous propylhexedrine abuse should be considered in the differential diagnosis of right ventricular hypertrophy and/or pulmonary hypertension, and it should be suspected in cases of sudden death involving young adults displaying evidence of intravenous drug abuse [3].
• This paper reviews the pharmacology, medicinal uses, toxicity and abuse-potential of propylhexedrine, with special emphasis on toxicity and abuse potential [4].

Psychiatry related information on Propylhexedrine

• In young adults with history of drug abuse, the IV use of Benzedrex should be considered in the differential diagnosis of transient or permanent focal brainstem deficits [5].

High impact information on Propylhexedrine

• We present the case of a 33-year-old white male truck driver with a ten-year history of 3.5-g/wk "crank" and "peanut butter methamphetamine" inhalation (methamphetamine and propylhexedrine, respectively) [6].
• When used as a nasal inhaler for this indication, propylhexedrine reduces nasal airway resistance without producing rebound congestion [4].
• The primary medicinal use of propylhexedrine is temporary symptomatic relief of nasal decongestion due to colds, allergies and allergic rhinitis [4].
• Propylhexedrine penetrated the blood-brain barrier rapidly [7].
• Pharmacokinetics of phenobarbital and propylhexedrine after administration of barbexaclone in the mouse [7].

Chemical compound and disease context of Propylhexedrine

• In 1949, amphetamine sulfate was replaced by propylhexedrine in the nasal decongestant agent Benzedrex because of psychosis, sudden death, and widespread abuse [5].
• Systemic application of d-methamphetamine or propylhexedrine given prior to infusion resulted in a dose dependent reduction of hyperphagia [8].

Biological context of Propylhexedrine

• In sum, the insult to tissue from intravascular or local injection with propylhexedrine appears to respond, although poorly, to efforts to reverse the intense pharmacologic vasoconstriction [9].
• Comparative kinetics of phenobarbital after administration of the acid and the propylhexedrine salt (barbexaclone) [10].

Anatomical context of Propylhexedrine

• This report describes an inadvertent case of intra-arterial propylhexedrine injection into the radial artery, the natural course of which resulted in digital amputations [11].

Analytical, diagnostic and therapeutic context of Propylhexedrine

• Abuse does not occur by nasal inhalation; however, a small amount of abuse of the propylhexedrine containing nasal inhalers occurs by oral ingestion of the contents of the inhaler or by intravenous injection [4].
• Because the actual constituents of the injected material prepared from the inhalers were not established, solutions were prepared from Benzedrex Inhalers according to the formula provided by one of the patients [9].

References