Disease relevance of Curban

• Within a behavioral self-management treatment program for overweight, 59 patients were randomly assigned to receive as an adjunct either dextroamphetamine sulfate, fenfluramine hydrochloride, or placebo in a double-blind procedure [1].
• The abuse pattern and symptoms of toxicity were similar to that seen with cocaine hydrochloride and amphetamine sulfate addiction; yet, the morbidity and mortality seen in this case series were greater than usual for a group of patients involved in intravenous drug abuse [2].
• After infarction, T-maze performance was assessed repeatedly in rats receiving 2 (n = 10) or 4 (n = 10) mg/kg d-amphetamine sulfate or saline (n = 9) 24 hours prior to testing on days 4, 6, 9, and 11 [3].
• These data provide further evidence of the facilitatory effect of d-amphetamine sulfate on recovery from brain injury and extend this effect to the enhancement of recovery subsequent to thrombotic infarction of the primary somatosensory cortex [3].
• Doses of d-amphetamine sulfate (0.1, 0.15, and 0.2 mg/kg body weight) were given to adult monkeys in mother-infant pairs [4].

Psychiatry related information on Curban

• The effects of a single oral dose of dextroamphetamine sulfate on motor activity, vigilance, learning, and mood were compared for normal and hyperactive prepubertal boys and normal college-aged men using a double-blind crossover design [5].
• In our study, concentrations of plasma HVA and urinary HVA (from 24-hour urine collections) were measured in 20 prepubescent boys who received 3 weeks of placebo, dextroamphetamine sulfate, and fenfluramine hydrochloride in a randomized, double-blind, counterbalanced study of the treatment of attention-deficit disorder [6].
• Bupropion hydrochloride (100, 200, and 400 mg), d-amphetamine sulfate (15 and 30 mg), and placebo were compared in 13 volunteers who had histories of amphetamine abuse [7].
• Castrating male rats in adulthood increased the duration of stereotyped behavior in responses of 5 mg/kg injections of d-amphetamine sulfate; exogenous treatment with testosterone propionate (TP) reversed this effect [8].
• On Dexedrine, he developed frank visual hallucinations [9].

High impact information on Curban

• Dexamyl, abdominal angina, and celiac-artery compression [10].
• Brain polysomes are disaggregated in rats given moderate to large doses of d-amphetamine sulfate; this response is rapid in onset, lasts for at least 4-6 hr, and varies with the age of the animal [11].
• We have previously reported that, 30 min after a single injection of 7.5 mg/kg d-amphetamine sulfate, there was a significant 25% decrease in the apparent Vmax for stimulation of adenylate cyclase activity by the D1 receptor-selective partial agonist SKF 38393 in rat striatal membranes, as compared with saline-injected controls [12].
• Changes in locomotor and stereotypic activities induced by an i.p. injection of either (+)-5-methyl-10,11-dihydro-5H-dibenzo(a,d)-cycloheptan-5,10-imine maleate (dizocilpine or MK-801; 0.3 mg/kg) or D-amphetamine sulfate (AMPH; 1.5 mg/kg) were studied in male Mill Hill hooded rats of different age [13].
• The same cocktail of dopamine + d-amphetamine sulfate + pargyline injected in prefrontal cortex of self-stimulators simply attenuated or suppressed responding, and the effect lasted for most of the session [14].

Chemical compound and disease context of Curban

• Charles River CD-1 mice (30-35 g body weight) were injected with AT just before the injection of d-amphetamine sulphate (20 mg/kg). d-Amphetamine stimulated the production of H2O2 in all tissues studied, although to different degrees [15].
• The effects of d-amphetamine sulfate and methylphenidate hydrochloride on auditory thresholds in ten squirrel monkeys were examined using a 4.2 kHz stimulus in a free field [16].
• Lysergic acid diethylamide and dimethyltryptamine could be distinguished from saline, chlorpromazine, d-amphetamine sulfate, and bromo-lysergic acid diethylamide by the increased frequency of spasms, stereotypy, bump, and tracking [17].
• Twenty patients with the narcoleptic syndrome were treated separately with dexamphetamine sulphate tablets 10 and 30 mg, Dexedrine Spansules 10 mg, mazindol 4 mg, and fencamfamin hydrochloride 60 mg daily [18].
• CONCLUSIONS: Idiopathic orthostatic cyclic edema can cause vasomotor flushing even with normal estrogen and serum FSH, and treatment of the edema state with the drug of choice dextroamphetamine sulfate can effectively control these symptoms [19].

Biological context of Curban

• Regional cerebral blood flow (CBF), blood pressure, pulse rate, respiratory rate, end-tidal carbon dioxide and mood states were measured before and after IV injections of 15 mg dextroamphetamine sulfate or saline in 22 physically and mentally healthy normal volunteers [20].
• If sodium pentobarbital is injected into rats 30 min prior to d-amphetamine sulphate on four or five occasions, there is a learned effect of pentobarbital on heart rate [21].
• In a sub-experiment, it was demonstrated that 1.0 mg/kg d-amphetamine sulfate reduced food intake by 25%, but this anorexic action was completely attenuated by 0.8 mg/kg haloperidol given 45 minutes prior to feeding [22].
• Video data of 14 youth pitchers throwing fastballs were used to calculate shoulder and elbow kinematics and kinetics [23].
• Pregnant albino mice (ICR random-bred strain) received daily injections of 50 or 100 mg/kg body weight of D-amphetamine sulphate between days 9 and 11 of gestation [24].

Anatomical context of Curban

• In the rat, d-amphetamine sulfate (15--80 mg/kg) causes numerous behavioral effects including simultaneous side-to-side head weaving or head tremor, forepaw padding and splayed hindlimbs [25].
• Ipsilateral microinjections (2.5, 5.0 and 10.0 micrograms/0.5 microliter) of D-amphetamine sulfate into the nucleus accumbens also caused shifts to the left of the rate-frequency function; no central dose caused a change in the asymptotic response rate associated with high stimulation frequencies [26].
• Moreover, D-amphetamine sulfate dose-dependently suppressed [3H]nicotine binding to chromaffin cells [27].
• In general, D-amphetamine sulfate (2.0 mg/kg) produced an initial increase in firing rate of neurons in the caudate nucleus approximately 8-10 min following intraperitoneal injection, and a subsequent depression of firing rat which lasted for a period of time of from 70 to 120 min [28].
• OBJECTIVE: To examine the use of the central nervous system stimulant dextroamphetamine sulfate to regulate appetite and subsequent weight gain in children treated for craniopharyngioma [29].

Associations of Curban with other chemical compounds

• However, animals failed to show generalization between the training drug (20 mg/kg TRH) and d-amphetamine sulfate (0.8, 1.6, or 2.4 mg/kg); likewise, animals trained to discriminate d-amphetamine (0.8 or 1.6 mg/kg) from saline failed to show generalization between d-amphetamine and TRH (10, 20, OR 30 MG/KG) [30].
• The effects of chlorpromazine and dextroamphetamine sulfate on the visual stimulation preference of extraverts and introverts [31].
• Dopamine receptor activation in accumbens or prefrontal cortex was induced with bilateral injections in these structures of a mixture containing 5 mg dopamine, 10 mg d-amphetamine sulfate and 5 mg pargyline mixed in 0.5 ml saline containing 0.1% ascorbic acid (dopamine + d-amphetamine sulfate + pargyline, the cocktail) [14].
• The effect of ibogaine hydrochloride on locomotor stimulation induced by d-amphetamine sulfate was tested in male C57BL/6By mice and in female Sprague-Dawley rats [32].
• Intraperitoneal d-amphetamine sulfate (5mg/kg) increased ascorbate concentrations in striatal extracellular fluid [33].

Gene context of Curban

• Chronic d-amphetamine sulfate (5 mg/kg twice daily X 7 days) had no effect on CCK binding in cortex or caudate nucleus [34].
• A 10(-5) mol dm(-3) solution (the final concentration after addition of colloid was 10(-6) mol dm(-3)) of amphetamine sulfate was detected from gold colloid with an RSD of 5.4% [35].
• September 11; also: dexedrine or surgery for exotropia? Modified Foster; DEP or masked DVD?; You're not very good at gaze and head tilt angles; more on atropine for myopia and ARM [36].

Analytical, diagnostic and therapeutic context of Curban

• The addition of d-amphetamine sulfate to the perfusing CSF for 2 hours, beginning 2 hours after the start of the 3H-tyrosine perfusion, caused an immediate increase in the efflux of 3H-dopamine [37].
• Differential dose-response effects of dexamphetamine sulphate on hunger, arousal and mood in human volunteers [38].
• In a second experiment designed to minimize differences in acquisition and examine stable self-administration, lever pressing for a low (0.10 mg/kg, IV) or high (0.25 mg/kg, IV) dose of D-amphetamine sulfate was measured in rats pretrained to lever press for food [39].
• One week later, locomotion was recorded in the same activity boxes following a subcutaneous injection with d-amphetamine sulfate (1 mg/kg) [40].
• All subjects were given 20 mg of dextroamphetamine sulfate, a drug widely used in the treatment of this disorder, and blood samples were collected before and 30, 60, and 90 minutes after treatment [41].

References