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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
MeSH Review

Airway Resistance

 
 
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Disease relevance of Airway Resistance

  • Putative therapeutic application of NPY in rhinitis has been recently suggested because intranasal administration of exogenous NPY in human beings reduces nasal airway resistance and vascular permeability without affecting submucosal gland secretion [1].
  • The purpose of this study was to determine whether heparin inhibits the late-phase response to hyperventilation, which is characterized by increased peripheral airway resistance (RP), eicosanoid mediator production, neutrophilic/ eosinophilic inflammation, and airway hyperreactivity (AHR) at 5 h after dry air challenge (DAC) [2].
  • Salbutamol inhibits neutropenia, increased airway resistance, and gas exchange abnormalities provoked by platelet-activating factor (PAF) challenge in normal persons [3].
  • Nine men (age 49 +/- 10 yr) with mild to moderate sleep apnea syndrome (AHI of 25.1 +/- 10. 8/h) were studied and 340 ONAREs (hypopneas and upper airway resistance episodes) were randomly selected for scoring by two experienced observers [4].
  • The physiology of the upper airway during sleep mimics the behavior of a collapsible tube; CPAP prevents the negative intraluminal pressure thought to cause apnea, hypopnia and increases in airway resistance [5].
 

Psychiatry related information on Airway Resistance

  • As the change in ventilation has been shown to occur abruptly at transitions between alpha and theta electroencephalogram activity, it was of interest to determine whether the increase in airway resistance between wakefulness and sleep also occurs at these transitions [6].
 

High impact information on Airway Resistance

 

Chemical compound and disease context of Airway Resistance

 

Biological context of Airway Resistance

 

Anatomical context of Airway Resistance

 

Associations of Airway Resistance with chemical compounds

  • Compared to nonsensitized monkeys, there was a fourfold reduction in the dose of histamine aerosol necessary to produce a 150% increase in airway resistance in sensitized monkeys [27].
  • During aerosol challenge with HDMA, sensitized monkeys exhibited cough and rapid shallow breathing and increased airway resistance, which was reversed by albuterol aerosol treatment [27].
  • RESULTS: Anti-PDGF-beta neutralizing antibody significantly inhibited both the elevation of airway resistance elicited by 1.25 and 2.5 mg/mL acetylcholine and the increase in the airway wall thickening induced by DEPs [28].
  • Baseline specific airway resistance was significantly reduced by both doses of atropine but was no different after 2.08 mg than after 0.26 mg [29].
  • Airway resistance was measured to verify the occurrence of airway narrowing and increased significantly in sensitized rats after allergen challenge but did not change in controls [30].
 

Gene context of Airway Resistance

 

Analytical, diagnostic and therapeutic context of Airway Resistance

References

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