Disease relevance of UN2320

• Linear polyamine copper chelator tetraethylenepentamine augments long-term ex vivo expansion of cord blood-derived CD34+ cells and increases their engraftment potential in NOD/SCID mice [1].
• Occupational epoxy dermatitis with patch test reactions to multiple hardeners including tetraethylenepentamine [2].

High impact information on UN2320

• Catechol, triethylenetetramine, and tetraethylenepentamine were found to be such agents when erythrocytes were dialyzed in the cold against dilute solutions of these chelators [3].
• OBJECTIVES: We have demonstrated epigenetic modulation of CD34(+) cell differentiation by the high-affinity copper (Cu) chelator tetraethylenepentamine (TEPA) [4].
• In the present study, we evaluated the effect of short-term (3-week) treatment with the copper chelator tetraethylenepentamine (TEPA) on short- and long-term (up to 11 weeks) ex vivo expansion of hematopoietic progenitors, as well as on their SCID engraftment potential [1].
• Treatment of Hep G2 cells with increasing concentrations of the copper chelator tetraethylenepentamine (TEPA, 0-50 micromol/L, 48 h) reduced cellular copper and increased mean p53 mRNA abundance by over fourfold with nuclear translocation of the wild-type protein [5].
• HL-60 cells, a human promyelocytic cell line, were induced to differentiate with retinoic acid and were concurrently supplemented with copper or a copper chelator, tetraethylenepentamine [6].

Biological context of UN2320

• To determine if copper deficiency per se leads to apoptosis, C2C12 cells were made copper deficient by treatment with the copper chelator tetraethylenepentamine (TEPA) [7].

Anatomical context of UN2320

• HL-60 cells can be made copper deficient by incubating with tetraethylenepentamine [8].
• We have previously found that the synthetic polyamine tetraethylenepentamine (TEPA) significantly delayed differentiation and prolonged expansion of cord-blood derived HPC in cytokine-supplemented cultures [9].
• Pre-clinical development of cord blood-derived progenitor cell graft expanded ex vivo with cytokines and the polyamine copper chelator tetraethylenepentamine [10].
• BACKGROUND: We have previously demonstrated that the copper chelator tetraethylenepentamine (TEPA) enables preferential expansion of early hematopoietic progenitor cells (CD34+CD38-, CD34+CD38-Lin-) in human umbilical cord blood (CB)-derived CD34+ cell cultures [10].

Associations of UN2320 with other chemical compounds

• In a micronucleus study with Swiss-Webster mice, no clastogenic activity was observed with TETA, TEPA and AEP [11].
• The overall weight of evidence from the in vitro and in vivo tests suggested that EDA, DETA and AEEA were not mutagenic, while TETA was mutagenic, and TEPA and AEP had a weak mutagenic potential [11].
• Three preparation batches of the recombinant birch pollen allergen Bet v 1a have been analyzed by capillary zone electrophoresis (CZE) using a separation electrolyte consisting of 100 mmol L(-1) phosphate at pH 6.50 with 2.0 mmol L(-1) tetraethylenepentamine (TEPA) added [12].

Gene context of UN2320

• The effect of tetraethylenepentamine, a synthetic copper chelating polyamine, on expression of CD34 and CD38 antigens on normal and leukemic hematopoietic cells [9].
• One chelator, tetraethylenepentamine (TEPA), reduced cellular copper levels and the activities of two copper-requiring enzymes, Cu/Zn-superoxide dismutase (Cu/Zn-SOD) and cytochrome c oxidase [8].

Analytical, diagnostic and therapeutic context of UN2320

• Normal-phase high-performance liquid chromatography of porphyrin free acids on silica modified with tetraethylenepentamine [13].

References