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Chemical Compound Review

Tetrene     N'-(2-aminoethyl)-N-[2-(2...

Synonyms: Tetren, CHEMBL138297, CCRIS 6275, DEH 26, LS-557, ...
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Disease relevance of UN2320


High impact information on UN2320


Biological context of UN2320

  • To determine if copper deficiency per se leads to apoptosis, C2C12 cells were made copper deficient by treatment with the copper chelator tetraethylenepentamine (TEPA) [7].

Anatomical context of UN2320


Associations of UN2320 with other chemical compounds

  • In a micronucleus study with Swiss-Webster mice, no clastogenic activity was observed with TETA, TEPA and AEP [11].
  • The overall weight of evidence from the in vitro and in vivo tests suggested that EDA, DETA and AEEA were not mutagenic, while TETA was mutagenic, and TEPA and AEP had a weak mutagenic potential [11].
  • Three preparation batches of the recombinant birch pollen allergen Bet v 1a have been analyzed by capillary zone electrophoresis (CZE) using a separation electrolyte consisting of 100 mmol L(-1) phosphate at pH 6.50 with 2.0 mmol L(-1) tetraethylenepentamine (TEPA) added [12].

Gene context of UN2320

  • The effect of tetraethylenepentamine, a synthetic copper chelating polyamine, on expression of CD34 and CD38 antigens on normal and leukemic hematopoietic cells [9].
  • One chelator, tetraethylenepentamine (TEPA), reduced cellular copper levels and the activities of two copper-requiring enzymes, Cu/Zn-superoxide dismutase (Cu/Zn-SOD) and cytochrome c oxidase [8].

Analytical, diagnostic and therapeutic context of UN2320


  1. Linear polyamine copper chelator tetraethylenepentamine augments long-term ex vivo expansion of cord blood-derived CD34+ cells and increases their engraftment potential in NOD/SCID mice. Peled, T., Landau, E., Mandel, J., Glukhman, E., Goudsmid, N.R., Nagler, A., Fibach, E. Exp. Hematol. (2004) [Pubmed]
  2. Occupational epoxy dermatitis with patch test reactions to multiple hardeners including tetraethylenepentamine. Kanerva, L., Jolanki, R., Estlander, T. Contact Derm. (1998) [Pubmed]
  3. Inactivation of intracellular copper-zinc superoxide dismutase by copper chelating agents without glutathione depletion and methemoglobin formation. Kelner, M.J., Bagnell, R., Hale, B., Alexander, N.M. Free Radic. Biol. Med. (1989) [Pubmed]
  4. Chelatable cellular copper modulates differentiation and self-renewal of cord blood-derived hematopoietic progenitor cells. Peled, T., Glukhman, E., Hasson, N., Adi, S., Assor, H., Yudin, D., Landor, C., Mandel, J., Landau, E., Prus, E., Nagler, A., Fibach, E. Exp. Hematol. (2005) [Pubmed]
  5. Tumor suppressor protein p53 mRNA and subcellular localization are altered by changes in cellular copper in human Hep G2 cells. Narayanan, V.S., Fitch, C.A., Levenson, C.W. J. Nutr. (2001) [Pubmed]
  6. Copper is required to maintain Cu/Zn-superoxide dismutase activity during HL-60 cell differentiation. Percival, S.S., Bae, B., Patrice, M. Proc. Soc. Exp. Biol. Med. (1993) [Pubmed]
  7. Mitochondrial membrane potential is reduced in copper-deficient C2C12 cells in the absence of apoptosis. Chen, X., Medeiros, D.M., Jennings, D. Biological trace element research. (2005) [Pubmed]
  8. HL-60 cells can be made copper deficient by incubating with tetraethylenepentamine. Percival, S.S., Layden-Patrice, M. J. Nutr. (1992) [Pubmed]
  9. The effect of tetraethylenepentamine, a synthetic copper chelating polyamine, on expression of CD34 and CD38 antigens on normal and leukemic hematopoietic cells. Prus, E., Peled, T., Fibach, E. Leuk. Lymphoma (2004) [Pubmed]
  10. Pre-clinical development of cord blood-derived progenitor cell graft expanded ex vivo with cytokines and the polyamine copper chelator tetraethylenepentamine. Peled, T., Mandel, J., Goudsmid, R.N., Landor, C., Hasson, N., Harati, D., Austin, M., Hasson, A., Fibach, E., Shpall, E.J., Nagler, A. Cytotherapy. (2004) [Pubmed]
  11. Evaluation of the genotoxic potential of alkyleneamines. Leung, H.W. Mutat. Res. (1994) [Pubmed]
  12. Profiling preparations of recombinant birch pollen allergen Bet v 1a with capillary zone electrophoresis in pentamine modified fused-silica capillaries. Punzet, M., Ferreira, F., Briza, P., van Ree, R., Malissa, H., Stutz, H. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. (2006) [Pubmed]
  13. Normal-phase high-performance liquid chromatography of porphyrin free acids on silica modified with tetraethylenepentamine. Lim, C.K., Chan, J.Y. J. Chromatogr. (1982) [Pubmed]
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