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Chemical Compound Review

dien     N-(2-aminoethyl)ethane-1,2- diamine

Synonyms: Epicure T, ChS-P 1, Barsamide 115, Ancamine DETA, NSC-446, ...
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Disease relevance of DETA


High impact information on DETA


Chemical compound and disease context of DETA


Biological context of DETA


Anatomical context of DETA


Associations of DETA with other chemical compounds


Gene context of DETA

  • Two NO donors upregulated VSMC surface TNF-R1, and exogenous TNF-alpha induced VSMC apoptosis synergistically with the NO donor diethylenetriamine/NO, indicating that NO sensitizes VSMCs to TNF-alpha [30].
  • Employing this approach, biglycan expression turned out to be down-regulated time- and dose-dependently either by interleukin-1beta-stimulated endogenous nitric oxide production or by direct application of the exogenous nitric oxide donor, diethylenetriamine nitric oxide [31].
  • Treatment with the nitric oxide (NO) donor diethylenetriamine NONOate increased BrdU incorporation and cell counts in eNOS(-/-) cardiomyocytes (P < 0.05) [32].
  • The NO donors S-nitroso-N-acetyl-penicillamine and diethylenetriamine/NO further reduced SPARC expression in cytokine-treated MC as well as in controls [33].
  • Kinetic modeling of 99mTc-labeled diethylenetriamine pentaacetic acid-galactosyl-human serum albumin (TcGSA) time-activity data yields estimates of ASGP-R concentration [R]o and amount R0, which are directly related to functional liver mass [34].

Analytical, diagnostic and therapeutic context of DETA

  • The particulate fraction of PKCeta rose from 66+/-5% in the control group to 86+/-3% after ischemic PC (P<0.05), to 88+/-2% after SNAP (P<0.05) and to 85+/-1% after DETA/NO (P<0.05) [35].
  • Perfusates contained 99mTc-DTPA (diethylenetriamine pentaacetic acid) and volumes of the right colon were determined by two plane scintigraphy using gamma cameras [36].
  • The pulmonary perfusion pressure-flow curves were shifted downwards by DETA/NO treatment, indicating improved resistive properties of the pulmonary vasculature [19].
  • METHODS: In 48 women, with either idiopathic (n = 36) or acquired (n = 12) STC, 111In-radiolabelled diethylene-triamine penta-acetic acid colonic scintigraphy was performed to determine patterns of delay (generalized or left sided), the 'severity' of transit disturbance between subgroups, and the association with age or duration of symptoms [37].
  • The effect of hydration on the dose to the urinary bladder wall during technetium-99m diethylene triamine penta-acetic acid renography [38].


  1. Efficacy of treatment with the iron (III) complex of diethylenetriamine pentaacetic acid in mice and primates inoculated with live lethal dose 100 Escherichia coli. Molina, L., Studenberg, S., Wolberg, G., Kazmierski, W., Wilson, J., Tadepalli, A., Chang, A.C., Kosanke, S., Hinshaw, L. J. Clin. Invest. (1996) [Pubmed]
  2. Magnetic resonance imaging of acute myocardial infarction: gadolinium diethylenetriamine pentaacetic acid as a marker of reperfusion. Peshock, R.M., Malloy, C.R., Buja, L.M., Nunnally, R.L., Parkey, R.W., Willerson, J.T. Circulation (1986) [Pubmed]
  3. Specific radioimmunotherapy using 90Y-labeled monoclonal antibody in erythroleukemic mice. Anderson-Berg, W.T., Squire, R.A., Strand, M. Cancer Res. (1987) [Pubmed]
  4. Hypoxia potentiates nitric oxide-mediated apoptosis in endothelial cells via peroxynitrite-induced activation of mitochondria-dependent and -independent pathways. Walford, G.A., Moussignac, R.L., Scribner, A.W., Loscalzo, J., Leopold, J.A. J. Biol. Chem. (2004) [Pubmed]
  5. Radioisotopic imaging allows optimization of adenovirus lung deposition for cystic fibrosis gene therapy. Lerondel, S., Le Pape, A., Sené, C., Faure, L., Bernard, S., Diot, P., Nicolis, E., Mehtali, M., Lusky, M., Cabrini, G., Pavirani, A. Hum. Gene Ther. (2001) [Pubmed]
  6. Pathophysiological concentrations of glucose promote oxidative modification of low density lipoprotein by a superoxide-dependent pathway. Kawamura, M., Heinecke, J.W., Chait, A. J. Clin. Invest. (1994) [Pubmed]
  7. Molecular imaging of hepatocellular carcinoma. Gharib, A.M., Thomasson, D., Li, K.C. Gastroenterology (2004) [Pubmed]
  8. Increased sensitivity of Fancc-deficient hematopoietic cells to nitric oxide and evidence that this species mediates growth inhibition by cytokines. Hadjur, S., Jirik, F.R. Blood (2003) [Pubmed]
  9. Pharmacokinetics in patients of an anti-carcinoembryonic antigen antibody radiolabeled with indium-111 using a novel diethylenetriamine pentaacetic acid chelator. Hnatowich, D.J., Rusckowski, M., Brill, A.B., Siebecker, D.A., Misra, H., Mardirossian, G., Bushe, H., Rescigno, A., Stevens, S., Johnson, D.K. Cancer Res. (1990) [Pubmed]
  10. Stability, targeting, and biodistribution of scandium-46- and gallium-67-labeled monoclonal antibody in erythroleukemic mice. Anderson, W.T., Strand, M. Cancer Res. (1985) [Pubmed]
  11. Differential mechanisms of nitric oxide- and peroxynitrite-induced cell death. Meij, J.T., Haselton, C.L., Hillman, K.L., Muralikrishnan, D., Ebadi, M., Yu, L. Mol. Pharmacol. (2004) [Pubmed]
  12. Different kinetics of lung clearance of technetium-99m labelled diethylene triamine penta-acetic acid in patients with sarcoidosis and smokers. Brådvik, I., Wollmer, P., Evander, E., Lárusdóttir, H., Blom-Bülow, B., Jonson, B. European journal of nuclear medicine. (1994) [Pubmed]
  13. Optimising technetium 99m diethylene triamine penta-acetate lung clearance in patients with the acquired immunodeficiency syndrome. Van der Wall, H., Murray, I.P., Jones, P.D., Mackey, D.W., Walker, B.M., Monaghan, P. European journal of nuclear medicine. (1991) [Pubmed]
  14. Bleomycin lung toxicity detected by technetium-99m diethylene triamine penta-acetic acid aerosol scintigraphy. Ugur, O., Caner, B., Balbay, M.D., Ozen, H.A., Remzi, D., Ulutuncel, N., Bekdik, C. European journal of nuclear medicine. (1993) [Pubmed]
  15. The effects of ethanol and hyperosmotic perfusates on albumin synthesis and release. Rothschild, M.A., Oratz, M., Schreiber, S.S., Mongelli, J. Hepatology (1986) [Pubmed]
  16. Nitric oxide upregulates induction of PDGF receptor-alpha expression in rat renal mesangial cells and in anti-Thy-1 glomerulonephritis. Beck, K.F., Güder, G., Schaefer, L., Pleskova, M., Babelova, A., Behrens, M.H., Mihalik, D., Beck, M., Schaefer, R.M., Pfeilschifter, J. J. Am. Soc. Nephrol. (2005) [Pubmed]
  17. Endotoxin induces respiratory failure and increases surfactant turnover and respiration independent of alveolocapillary injury in rats. Davidson, K.G., Bersten, A.D., Barr, H.A., Dowling, K.D., Nicholas, T.E., Doyle, I.R. Am. J. Respir. Crit. Care Med. (2002) [Pubmed]
  18. Reversal of cyclosporine malabsorption in diabetic recipients of simultaneous pancreas and kidney transplant using a microemulsion formulation. Chapman, J.R., O'Connell, P.J., Bovington, K.J., Allen, R.D. Transplantation (1996) [Pubmed]
  19. Nebulized nitric oxide/nucleophile adduct reduces chronic pulmonary hypertension. Hampl, V., Tristani-Firouzi, M., Hutsell, T.C., Archer, S.L. Cardiovasc. Res. (1996) [Pubmed]
  20. The role of sulfur-containing amino acids in superoxide production and modification of low density lipoprotein by arterial smooth muscle cells. Heinecke, J.W., Rosen, H., Suzuki, L.A., Chait, A. J. Biol. Chem. (1987) [Pubmed]
  21. Nitric-oxide-induced depolarization of neuronal mitochondria: implications for neuronal cell death. Solenski, N.J., Kostecki, V.K., Dovey, S., Periasamy, A. Mol. Cell. Neurosci. (2003) [Pubmed]
  22. Enhancement of tumor-to-nontumor localization ratios by hepatocyte-directed blood clearance of antibodies labeled with certain residualizing radiolabels. Patel, S., Stein, R., Ong, G.L., Goldenberg, D.M., Mattes, M.J. J. Nucl. Med. (1999) [Pubmed]
  23. Nitric oxide induces rapid, calcium-dependent release of vesicular glutamate and ATP from cultured rat astrocytes. Bal-Price, A., Moneer, Z., Brown, G.C. Glia (2002) [Pubmed]
  24. Nitric oxide donors protect murine myocardium against infarction via modulation of mitochondrial permeability transition. Wang, G., Liem, D.A., Vondriska, T.M., Honda, H.M., Korge, P., Pantaleon, D.M., Qiao, X., Wang, Y., Weiss, J.N., Ping, P. Am. J. Physiol. Heart Circ. Physiol. (2005) [Pubmed]
  25. Ordering the cell death pathway. Differential effects of BCL2, an interleukin-1-converting enzyme family protease inhibitor, and other survival agents on JNK activation in serum/nerve growth factor-deprived PC12 cells. Park, D.S., Stefanis, L., Yan, C.Y., Farinelli, S.E., Greene, L.A. J. Biol. Chem. (1996) [Pubmed]
  26. Role of P450 aromatase in sex-specific astrocytic cell death. Liu, M., Hurn, P.D., Roselli, C.E., Alkayed, N.J. J. Cereb. Blood Flow Metab. (2007) [Pubmed]
  27. Additive effects of exposure to silica dust and smoking on pulmonary epithelial permeability: a radioaerosol study with technetium-99m labelled DTPA. Nery, L.E., Florencio, R.T., Sandoval, P.R., Rodrigues, R.T., Alonso, G., Mason, G.R. Thorax (1993) [Pubmed]
  28. Integrity of the alveolar-capillary barrier and alveolar surfactant system in smokers. Schmekel, B., Bos, J.A., Khan, A.R., Wohlfart, B., Lachmann, B., Wollmer, P. Thorax (1992) [Pubmed]
  29. Haem and nitric oxide: synergism in the modulation of the endothelial haem oxygenase-1 pathway. Foresti, R., Hoque, M., Bains, S., Green, C.J., Motterlini, R. Biochem. J. (2003) [Pubmed]
  30. Tumor necrosis factor-alpha promotes macrophage-induced vascular smooth muscle cell apoptosis by direct and autocrine mechanisms. Boyle, J.J., Weissberg, P.L., Bennett, M.R. Arterioscler. Thromb. Vasc. Biol. (2003) [Pubmed]
  31. Biglycan, a nitric oxide-regulated gene, affects adhesion, growth, and survival of mesangial cells. Schaefer, L., Beck, K.F., Raslik, I., Walpen, S., Mihalik, D., Micegova, M., Macakova, K., Schonherr, E., Seidler, D.G., Varga, G., Schaefer, R.M., Kresse, H., Pfeilschifter, J. J. Biol. Chem. (2003) [Pubmed]
  32. Lack of endothelial nitric oxide synthase decreases cardiomyocyte proliferation and delays cardiac maturation. Lepic, E., Burger, D., Lu, X., Song, W., Feng, Q. Am. J. Physiol., Cell Physiol. (2006) [Pubmed]
  33. Downregulation of SPARC expression is mediated by nitric oxide in rat mesangial cells and during endotoxemia in the rat. Walpen, S., Beck, K.F., Eberhardt, W., Apel, M., Chatterjee, P.K., Wray, G.M., Thiemermann, C., Pfeilschifter, J. J. Am. Soc. Nephrol. (2000) [Pubmed]
  34. Recovery of hepatic asialoglycoprotein receptors after major hepatic resection. Kokudo, N., Vera, D.R., Koizumi, M., Seki, M., Sato, T., Stadalnik, R.C., Takahashi, T. J. Nucl. Med. (1999) [Pubmed]
  35. Isoform-selective activation of protein kinase C by nitric oxide in the heart of conscious rabbits: a signaling mechanism for both nitric oxide-induced and ischemia-induced preconditioning. Ping, P., Takano, H., Zhang, J., Tang, X.L., Qiu, Y., Li, R.C., Banerjee, S., Dawn, B., Balafonova, Z., Bolli, R. Circ. Res. (1999) [Pubmed]
  36. Colonic capacitance and transit in man: modulation by luminal contents and drugs. Kamath, P.S., Phillips, S.F., O'Connor, M.K., Brown, M.L., Zinsmeister, A.R. Gut (1990) [Pubmed]
  37. Scintigraphic assessment of colonic transit in women with slow-transit constipation arising de novo and following pelvic surgery or childbirth. Scott, S.M., Knowles, C.H., Newell, M., Garvie, N., Williams, N.S., Lunniss, P.J. The British journal of surgery. (2001) [Pubmed]
  38. The effect of hydration on the dose to the urinary bladder wall during technetium-99m diethylene triamine penta-acetic acid renography. Dimitriou, P.A., Tsinikas, D.T., Depaskouale, A.K., Kasfiki, A.G., Antipas, S.E. European journal of nuclear medicine. (1992) [Pubmed]
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