Chemical Compound Review:
trientine N,N'-bis(2-aminoethyl)ethane- 1,2-diamine
Synonyms:
Trientina, Trientinum, Tecza, Trien, TETA, ...
Cooper,
Chan,
Dissanayake,
Leahy,
Keogh,
Frampton,
Gamble,
Brunton,
Baker,
Poppitt,
Moriguchi,
Nakajima,
Kimura,
Watanabe,
Takashima,
Mitsumoto,
Katagishi,
Okanoue,
Kagawa,
Brewer,
Boca,
Gembický,
Herchel,
Haase,
Jäger,
Wagner,
Ehrenberg,
Fuess,
Brewer,
Askari,
Lorincz,
Carlson,
Schilsky,
Kluin,
Hedera,
Moretti,
Fink,
Tankanow,
Dick,
Sitterly,
Brewer,
El-Youssef,
- The use of trientine in preventing the effects of interrupting penicillamine therapy in Wilson's disease. Scheinberg, I.H., Jaffe, M.E., Sternlieb, I. N. Engl. J. Med. (1987)
- Triethylene tetramine dihydrochloride toxicity in primary biliary cirrhosis. Epstein, O., Sherlock, S. Gastroenterology (1980)
- Demonstration of a hyperglycemia-driven pathogenic abnormality of copper homeostasis in diabetes and its reversibility by selective chelation: quantitative comparisons between the biology of copper and eight other nutritionally essential elements in normal and diabetic individuals. Cooper, G.J., Chan, Y.K., Dissanayake, A.M., Leahy, F.E., Keogh, G.F., Frampton, C.M., Gamble, G.D., Brunton, D.H., Baker, J.R., Poppitt, S.D. Diabetes (2005)
- Wilson disease and canine copper toxicosis. Brewer, G.J. Am. J. Clin. Nutr. (1998)
- The copper-chelating agent, trientine, suppresses tumor development and angiogenesis in the murine hepatocellular carcinoma cells. Yoshii, J., Yoshiji, H., Kuriyama, S., Ikenaka, Y., Noguchi, R., Okuda, H., Tsujinoue, H., Nakatani, T., Kishida, H., Nakae, D., Gomez, D.E., De Lorenzo, M.S., Tejera, A.M., Fukui, H. Int. J. Cancer (2001)
- Neurovascular dysfunction in diabetic rats. Potential contribution of autoxidation and free radicals examined using transition metal chelating agents. Cameron, N.E., Cotter, M.A. J. Clin. Invest. (1995)
- Treatment of Wilson's disease with trientine (triethylene tetramine) dihydrochloride. Walshe, J.M. Lancet (1982)
- Inhibition of hereditary hepatitis and liver tumor development in Long-Evans cinnamon rats by the copper-chelating agent trientine dihydrochloride. Sone, K., Maeda, M., Wakabayashi, K., Takeichi, N., Mori, M., Sugimura, T., Nagao, M. Hepatology (1996)
- Prolonged copper depletion induces expression of antioxidants and triggers apoptosis in SH-SY5Y neuroblastoma cells. Lombardo, M.F., Ciriolo, M.R., Rotilio, G., Rossi, L. Cell. Mol. Life Sci. (2003)
- Treatment of Wilson disease with ammonium tetrathiomolybdate: IV. Comparison of tetrathiomolybdate and trientine in a double-blind study of treatment of the neurologic presentation of Wilson disease. Brewer, G.J., Askari, F., Lorincz, M.T., Carlson, M., Schilsky, M., Kluin, K.J., Hedera, P., Moretti, P., Fink, J.K., Tankanow, R., Dick, R.B., Sitterly, J. Arch. Neurol. (2006)
- The efficacy of trientine or ascorbate alone compared to that of the combined treatment with these two agents in familial amyotrophic lateral sclerosis model mice. Nagano, S., Fujii, Y., Yamamoto, T., Taniyama, M., Fukada, K., Yanagihara, T., Sakoda, S. Exp. Neurol. (2003)
- Wilson disease. El-Youssef, M. Mayo Clin. Proc. (2003)
- Kinetics of copper(II)--glycylglycyl-L-histidine reactions. Acid decomposition and proton-assisted nucleophilic displacement by triethylenetetramine. Wong, L.F., Cooper, J.C., Margerum, D.W. J. Am. Chem. Soc. (1976)
- Decorporation of aged americium deposits by oral administration of lipophilic polyamino carboxylic acids. Bruenger, F.W., Kuswik-Rabiega, G., Miller, S.C. J. Med. Chem. (1992)
- Evaluation of the genotoxic potential of alkyleneamines. Leung, H.W. Mutat. Res. (1994)
- Inactivation of intracellular copper-zinc superoxide dismutase by copper chelating agents without glutathione depletion and methemoglobin formation. Kelner, M.J., Bagnell, R., Hale, B., Alexander, N.M. Free Radic. Biol. Med. (1989)
- Effects of chelator treatment on aorta and corpus cavernosum from diabetic rats. Keegan, A., Cotter, M.A., Cameron, N.E. Free Radic. Biol. Med. (1999)
- Activation of calcium uptake in rat liver mitochondria by aminoglucoside antibiotics. Kröner, H. Biochem. Pharmacol. (1990)
- Effect of thiol modulators and Cu/Zn superoxide dismutase inhibition on nitrergic relaxations in the rat gastric fundus. De Man, J.G., De Winter, B.Y., Boeckxstaens, G.E., Herman, A.G., Pelckmans, P.A. Br. J. Pharmacol. (1996)
- Almost total conversion of pancreas to liver in the adult rat: a reliable model to study transdifferentiation. Rao, M.S., Dwivedi, R.S., Subbarao, V., Usman, M.I., Scarpelli, D.G., Nemali, M.R., Yeldandi, A., Thangada, S., Kumar, S., Reddy, J.K. Biochem. Biophys. Res. Commun. (1988)
- Equilibrium studies on the binding of cadmium(II) to human serum transferrin. Harris, W.R., Madsen, L.J. Biochemistry (1988)
- Polymerase chain reaction-directed DNA sequencing of bleomycin-induced "nondeletion"-type, 6-thioguanine-resistant mutants in Chinese hamster ovary cell derivative AS52: effects of an inhibitor and a mimic of superoxide dismutase. An, J., Hsie, A.W. Environ. Mol. Mutagen. (1994)
- Separation of proteins on polymeric stationary phases grafted with various amine groups. Choi, S.H., Hwang, Y.M., Lee, K.P. Journal of chromatography. A. (2003)
- Reducible poly(amido ethylenimine) directed to enhance RNA interference. Hoon Jeong, J., Christensen, L.V., Yockman, J.W., Zhong, Z., Engbersen, J.F., Jong Kim, W., Feijen, J., Wan Kim, S. Biomaterials (2007)
- Influence of the "innocent" ligands on the MLCT excited-state behavior of mono(bipyridine)ruthenium(II) complexes: a comparison of X-ray structures and 77 K luminescence properties. Chen, Y.J., Xie, P., Heeg, M.J., Endicott, J.F. Inorganic chemistry. (2006)
- Chelation and intercalation: complementary properties in a compound for the treatment of Alzheimer's disease. Cherny, R.A., Barnham, K.J., Lynch, T., Volitakis, I., Li, Q.X., McLean, C.A., Multhaup, G., Beyreuther, K., Tanzi, R.E., Masters, C.L., Bush, A.I. J. Struct. Biol. (2000)
- Combination of copper-chelating agent, trientine, and methotrexate attenuates colorectal carcinoma development and angiogenesis in mice. Yoshiji, H., Yoshii, J., Kuriyama, S., Ikenaka, Y., Noguchi, R., Yanase, K., Namisaki, T., Kitade, M., Yamazaki, M., Fukui, H. Oncol. Rep. (2005)
- The copper chelator trientine has an antiangiogenic effect against hepatocellular carcinoma, possibly through inhibition of interleukin-8 production. Moriguchi, M., Nakajima, T., Kimura, H., Watanabe, T., Takashima, H., Mitsumoto, Y., Katagishi, T., Okanoue, T., Kagawa, K. Int. J. Cancer (2002)
- Anticopper therapy against cancer and diseases of inflammation and fibrosis. Brewer, G.J. Drug Discov. Today (2005)
- Wilson disease: genetic basis of copper toxicity and natural history. Schilsky, M.L. Semin. Liver Dis. (1996)
- Gallium-68 1,1,1-tris (5-methoxysalicylaldiminomethyl) ethane: a potential tracer for evaluation of regional myocardial blood flow. Green, M.A., Welch, M.J., Mathias, C.J., Fox, K.A., Knabb, R.M., Huffman, J.C. J. Nucl. Med. (1985)
- Ferromagnetism in a dinuclear nickel(II) complex containing triethylenetetramine and tricyanomethanide. Boca, R., Gembický, M., Herchel, R., Haase, W., Jäger, L., Wagner, C., Ehrenberg, H., Fuess, H. Inorganic chemistry. (2003)