Disease relevance of C09771

• Loganic acid was the most active (44.4% edema inhibition) on the former test, whereas the catalpol derivative mixture isolated from Scrophularia, aucubin, verbenalin, and loganin, showed the highest activity (from 72.0 to 80.0% edema inhibition) on the latter [1].
• In view of a possible involvement of these protein adducts in the toxicity of aucubin, we investigated the mechanism of binding of aucubin to proteins [2].

High impact information on C09771

• Anti-inflammatory activity of aucubin by inhibition of tumor necrosis factor-alpha production in RAW 264.7 cells [3].
• In the LTC4-assay, only aucubin showed a significant effect, with an IC50 value of 72 microM [4].
• In addition to aucubin, 6beta-hydroxyboschnaloside, and 6- O-(8''-hydroxy-2'',6''-dimethyl-2''( E), 6''( E)-octadienoyl)-6beta-hydroxyboschnaloside, the new iridoid glucoside ovatuside has been isolated from the aerial parts of PENSTEMON OVATUS [5].
• In vitro antispasmodic activity of peracetylated penstemonoside, aucubin and catalpol [6].
• In vitro, the peracetates of penstemonoside, aucubin and catalpol, iridoids isolated from Parentucellia latifolia, antagonize the uterine muscular contractions induced by acetylcholine and calcium, in a similar way to papaverine [6].

Biological context of C09771

• Plasma protein binding of aucubin was only 9% [7].
• Regioselective and stereospecific amination of iridoids: conversion of aucubin into aminoside antibiotic analogues [8].
• Significant induction of aucubin and catalpol was observed in two of the three plant genotypes used in this study following inoculation with the pathogen [9].
• Plantago lanceolata individuals that were used for oviposition by M. cinxia had higher aucubin concentrations than random plants and neighboring plants [10].
• Protective effects of aucubin isolated from Eucommia ulmoides against UVB-induced oxidative stress in human skin fibroblasts [11].

Anatomical context of C09771

• The partition coefficients of aucubin between n-octanol and buffers of pH 3.0-10.0 were low, while 18.5 +/- 1.3% of aucubin in whole blood partitioned into the blood cells [7].
• In conclusion, these results suggest that aucubin is a specific inhibitor of NF-kappaB activation in mast cells, which might explain its beneficial effect in the treatment of chronic allergic inflammatory diseases [12].
• The inhibition of ethoxy coumarin O-deethylase (ECOD) activity by aucubin and its aglycone was examined in a microsomal system and in freshly isolated hepatocytes [13].
• Except for aucubin, these glucosides induced neurite outgrowth at 0.1 microgram/ml and above in medium after 3 d of treatment [14].
• Using the human skin fibroblast HS68 cell line in the present study, we investigated the photoprotective effects of aucubin from Eucommia ulmoides [11].

Associations of C09771 with other chemical compounds

• It was found that the representatives of Veroniceae, as well as Globularia, were characterized by mannitol, aucubin, catalpol and catalpol esters [15].
• Micellar electrokinetic chromatography (MEKC) was used for the separation and determination of two iridoid glycosides, aucubin and catalpol, in several Plantago species growing in Croatia: P. altissima L., P. argentea Chaix, P. coronopus L., P. holosteum Scop [16].
• The promoting effects of geniposidic acid and aucubin in Eucommia ulmoides Oliver leaves on collagen synthesis [17].
• Two new iridoids, 10-O-benzoylglobularigenin (1) and dumuloside (2) were isolated from the aerial parts of Globularia dumulosa together with seven known iridoid glucosides, davisioside (3), aucubin (4), melampyroside (5), catalpol (6), 10-O-benzoylcatalpol (7), alpinoside (8) and deacetylalpinoside (9) [18].
• In addition, GA (IC50: 4.43 x 10(-7) M), AU and GP were significantly inhibited proliferation of osteoclast [19].

Gene context of C09771

• Inhibition of TNF-alpha and IL-6 production by Aucubin through blockade of NF-kappaB activation RBL-2H3 mast cells [12].
• We studied the effect of aucubin on the TNF-alpha and IL-6 expression in Ag-stimulated rat basophilic leukemia (RBL)-2H3 mast cells [12].
• Aucubin also inhibited Ag-induced nuclear translocation of p65 subunit of NF-kappaB and degradation of IkappaBalpha [12].
• Inhibition of NF-kappaB activation by aucubin might be specific since activator protein-1 binding activity was not affected [12].
• Pretreatment with aucubin significantly inhibited the production of MMP-1 by 57% when compared to the UVB-irradiated cells [11].

Analytical, diagnostic and therapeutic context of C09771

• Aucubin, which was not included in the sample mixture used in method development because of overlapping with catalpol in MEKC, was also detected [20].
• Liver-protective activities of aucubin derived from traditional oriental medicine [21].
• The duration of hypnosis for the saline control group, the CCl4 alone treated group and the aucubin plus CCl4 treated group was 24.8 +/- 8.5, 60.5 +/- 9.5 and 28.0 +/- 3.2 min, respectively [22].

References