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Chemical Compound Review

Kotetsu     4-bromo-2-(4-chlorophenyl)- 1...

Synonyms: Pirate, Pylon, Chlorfenapyr, Pirate 3F, PubChem2383, ...
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Disease relevance of Chlorfenapyr

  • Although chlorfenapyr remained in sediment, TWAs concentrations from the microcosm study along with model-predicted concentrations indicate low hazard to benthic invertebrate species based on acute toxicity to amphipods in the laboratory [1].
  • Liver and kidney weights and liver and kidney weight/body weight ratios exhibited a positive response to concentrations of chlorfenapyr in the diet [2].

High impact information on Chlorfenapyr

  • The photocatalytic degradation of chlorfenapyr followed pseudo-first-order degradation kinetics (Ct = C0e(-kt)) [3].
  • Emaciation and elevated organ weight/body weight ratios are candidates for a suite of indicators of chronic chlorfenapyr exposure [2].
  • Treatment with 6mg chlorfenapyr per kg BW in a 0.12ml per kg BW formulation was as effective as treatment with CyLence (cyfluthrin) in controlling naturally acquired Solenopotes capillatus (Enderlein) on cattle for 35 days [4].
  • The results of this study show that ear tags impregnated with chlorfenapyr are a useful alternative to pyrethroids and organo-phosphate compounds for horn fly control [5].
  • On the basis of these results the involvement of P450 MOs and esterases in the activation and detoxification of chlorfenapyr in T. urticae is challenged and discussed [6].

Chemical compound and disease context of Chlorfenapyr


Associations of Chlorfenapyr with other chemical compounds


Gene context of Chlorfenapyr

  • It was clear that two distinct zones of enhanced esterase activity were present in the chlorfenapyr-resistant strain (EST 11, pI = 4.88 and EST 16, pI = 4.71) [6].

Analytical, diagnostic and therapeutic context of Chlorfenapyr


  1. Fate and effects of the insecticide-miticide chlorfenapyr in outdoor aquatic microcosms. Rand, G.M. Ecotoxicol. Environ. Saf. (2004) [Pubmed]
  2. Chlorfenapyr and mallard ducks: overview, study design, macroscopic effects, and analytical chemistry. Albers, P.H., Klein, P.N., Green, D.E., Melancon, M.J., Bradley, B.P., Noguchi, G. Environ. Toxicol. Chem. (2006) [Pubmed]
  3. Mechanism and pathways of chlorfenapyr photocatalytic degradation in aqueous suspension of TiO2. Cao, Y., Yi, L., Huang, L., Hou, Y., Lu, Y. Environ. Sci. Technol. (2006) [Pubmed]
  4. Efficacy of chlorfenapyr (AC 303630) experimental pour-on and CyLence formulations against naturally acquired louse infestations on cattle in New York. Kaufman, P.E., Rutz, D.A., Doscher, M.E., Albright, R. Vet. Parasitol. (2001) [Pubmed]
  5. Chlorfenapyr ear tags to control Haematobia irritans (L.) (Diptera: Muscidae) on cattle. Guglielmone, A.A., Volpogni, M.M., Scherling, N., Cobeñas, M.M., Mangold, A.J., Anziani, O.S., Ioppolo, M., Doscher, M. Vet. Parasitol. (2000) [Pubmed]
  6. Biochemical analysis of a chlorfenapyr-selected resistant strain of Tetranychus urticae Koch. Van Leeuwen, T., Van Pottelberge, S., Tirry, L. Pest Manag. Sci. (2006) [Pubmed]
  7. Toxicity, persistence, and efficacy of spinosad, chlorfenapyr, and thiamethoxam on eggplant when applied against the eggplant flea beetle (Coleoptera: Chrysomelidae). McLeod, P., Diaz, F.J., Johnson, D.T. J. Econ. Entomol. (2002) [Pubmed]
  8. Genetic basis of resistances to chlorfenapyr and etoxazole in the two-spotted spider mite (Acari: Tetranychidae). Uesugi, R., Goka, K., Osakabe, M. J. Econ. Entomol. (2002) [Pubmed]
  9. Tebufenozide resistance selected in Plutella xylostella and its cross-resistance and fitness cost. Cao, G., Han, Z. Pest Manag. Sci. (2006) [Pubmed]
  10. Evaluation of a commercial immunoassay for the detection of chlorfenapyr in agricultural samples by comparison with gas chromatography and mass spectrometric detection. Watanabe, E., Baba, K., Eun, H., Arao, T., Ishii, Y., Ueji, M., Endo, S. Journal of chromatography. A. (2005) [Pubmed]
  11. HPLC/UV analysis of chlorfenapyr residues in cabbage and soil to study the dynamics of different formulations. Cao, Y., Chen, J., Wang, Y., Liang, J., Chen, L., Lu, Y. Sci. Total Environ. (2005) [Pubmed]
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