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Chemical Compound Review

Pro-Banthine     methyl-dipropan-2-yl-[2-(9H- xanthen-9...

Synonyms: Ercotina, Pervagal, Corrigast, Ercorax, Ketaman, ...
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Disease relevance of propantheline


High impact information on propantheline

  • The postaglandin analogue 16,16-dimethyl prostaglandin E2, the H2-receptor antagonist cimetidine, and the anticholinergic agent probanthine, in both doses studied, all significantly reduced lesion formation [3].
  • If given intravenously in small doses, Pro-Banthine is a satisfactory alternative when glucagon is contraindicated or not available [1].
  • Because the ester linkage of PB in the 1:1 complex with alpha-CD and in the 2:1 complex with gamma-CD is located near hydroxyls of the CD rim, these complexes catalyze the hydrolysis of PB [4].
  • The dielectric constant of the binding site of PB is estimated from the ultraviolet maximum wavelength in reference with the ethanol-water and dioxane-water systems [4].
  • The effects of alpha-, beta-, and gamma-cyclodextrins (CDs) on the basic hydrolysis of propantheline bromide (PB) and oxyphenonium bromide (OB) are analyzed in terms of the stoichiometry and microenvironments of their complexes [4].

Biological context of propantheline

  • In contrast, the hydrolysis is inhibited by the formation of the 1:1 and 1:2 complexes of beta-CD and the 1:1 complex of gamma-CD because the ester linkage of PB is rather deeply incorporated into the CD cavities for these complexes [4].
  • Gastric cytoprotection by prostaglandins, ranitidine, and probanthine in rats. Role of endogenous prostaglandins [5].
  • The standard Pro-Banthine formulation was significantly more bioavailable, weight for weight, than either the developmental PA capsule (45 mg), p less than 0.05, or the two 30 mg PA tablets (60 mg), p less than 0.01, based on urinary excretion and plasma levels of PB and on salivary secretion and heart rate data [6].
  • Propantheline bromide plasma level, urinary excretion and pharmacological data in a comparison of the bioavailability of three oral formulations of Pro-Banthine [6].
  • Blood pressure, ECGs and rhythm strips were recorded in supine and upright postures, after exercise and DMT, after i.v. injection of atropine and after oral administration of probanthine [7].

Anatomical context of propantheline


Analytical, diagnostic and therapeutic context of propantheline


  1. The use of Pro-Banthine to induce gastrointestinal hypotonia. Merlo, R.B., Stone, M., Baugus, P., Martin, M. Radiology. (1978) [Pubmed]
  2. Hormonal and cholinergic effects on amylase and lysosomal enzyme activities in pancreatic tissue and ascites of rats with acute experimental pancreatitis. Evander, A., Lundquist, I., Ihse, I. J. Surg. Res. (1983) [Pubmed]
  3. Topical aspirin plus HCl gastric lesions in the rat. Cytoprotective effect of prostaglandin, cimetidine, and probanthine. Guth, P.H., Aures, D., Paulsen, G. Gastroenterology (1979) [Pubmed]
  4. Stoichiometric and microenvironmental effects on hydrolysis of propantheline and oxyphenonium bromides in cyclodextrin solutions. Funasaki, N., Ishikawa, S., Neya, S. Journal of pharmaceutical sciences. (2001) [Pubmed]
  5. Gastric cytoprotection by prostaglandins, ranitidine, and probanthine in rats. Role of endogenous prostaglandins. Konturek, S.J., Radecki, T., Brzozowski, T., Piastucki, I., Dembińska-Kieć, A., Zmuda, A. Scand. J. Gastroenterol. (1981) [Pubmed]
  6. Propantheline bromide plasma level, urinary excretion and pharmacological data in a comparison of the bioavailability of three oral formulations of Pro-Banthine. Rigby, G.V., Vose, C.W., Haskins, N.J., Allan, E.F., Harrison, I.R., Shelton, J.R., Brownsill, R.D., Perkins, R.M., Ford, G.C., Hawkins, A.J. European journal of drug metabolism and pharmacokinetics. (1983) [Pubmed]
  7. "Orthoryhthmia" or postural cardiac dysrhythmia: clinical significance. Dogra, R. The Journal of the Association of Physicians of India. (1996) [Pubmed]
  8. Double-blind evaluation of glucagon and propantheline bromide (pro-banthine) for hypotonic duodenography. Bertrand, G., Linscheer, W.G., Raheja, K.L., Woods, R.F. AJR. American journal of roentgenology. (1977) [Pubmed]
  9. Bioavailability of trithiozine (TR) in man and its relation to gastric secretion and gastrin plasma level. Gibiński, K., Rybicka, J., Górny, E., Bielecka, W. International journal of clinical pharmacology and biopharmacy. (1979) [Pubmed]
  10. Influence of gastrointestinal hormones on the course of acute experimental pancreatitis. Evander, A., Lundquist, I., Ihse, I. Hepatogastroenterology (1982) [Pubmed]
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