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Chemical Compound Review

Sophorose     (2R,3S,4R,5R)-3,4,5,6- tetrahydroxy-2-[(2S...

Synonyms: CHEBI:1230, CPD-13242, AC1L3OUS, AR-1E4703, FT-0637996, ...
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High impact information on Sophorose

  • Cellulase induction by sophorose was not affected by ace2 deletion [1].
  • Electrophoretic mobility shift assays, using cell-free extracts, identified induction-specific protein-DNA complexes: one complex of high mobility was observed under basal, noninduced conditions (glucose) with xyn2, which was in part replaced by a slow-migrating complex upon induction by xylan or sophorose [2].
  • Deletion of ace1 resulted in an increase in the expression of all the main cellulase genes and two xylanase genes in sophorose- and cellulose-induced cultures, indicating that ACEI acts as a repressor of cellulase and xylanase expression [3].
  • Addition of 2 mM sophorose, a putative inducer of cellulase gene expression, to such cultures induced the transcription of egl1 and egl2 and restored the ability to grow on cellulose [4].
  • Optimal activity with PNPG and cellobiose as the substrates is at pH 6.2 and 50 degrees C. The enzyme has high activity against sophorose (beta-1,2-glucobiose) and laminaribiose (beta-1,3-glucobiose) but has no activity against gentiobiose (beta-1,6-glucobiose) [5].

Biological context of Sophorose

  • Repression of beta-glucosidase reduces sophorose hydrolysis and thus may increase cellulase induction [6].
  • The induction response to sophorose concentration, although complicated by the metabolism of sophorose, shows saturation kinetics [7].
  • The involvement of cytochrome P450 in the synthesis of sophorose lipid by the hydroxylation of long-chain fatty acids was suggested from a simultaneous increase of cellular P450 content [8].
  • Sophorose induction of the promoter was retained even in deletion derivatives lacking sequences upstream of position -161, which retained about 70 bp upstream of the transcription start point and only 30 bp upstream of the TATA box [9].
  • The result of the substrate specificity for phosphorolysis was that the chimera acted on nigerose, sophorose and laminaribiose, in addition to kojibiose [10].

Anatomical context of Sophorose


Associations of Sophorose with other chemical compounds


Gene context of Sophorose


Analytical, diagnostic and therapeutic context of Sophorose


  1. ACEII, a novel transcriptional activator involved in regulation of cellulase and xylanase genes of Trichoderma reesei. Aro, N., Saloheimo, A., Ilmén, M., Penttilä, M. J. Biol. Chem. (2001) [Pubmed]
  2. Different inducibility of expression of the two xylanase genes xyn1 and xyn2 in Trichoderma reesei. Zeilinger, S., Mach, R.L., Schindler, M., Herzog, P., Kubicek, C.P. J. Biol. Chem. (1996) [Pubmed]
  3. ACEI of Trichoderma reesei is a repressor of cellulase and xylanase expression. Aro, N., Ilmén, M., Saloheimo, A., Penttilä, M. Appl. Environ. Microbiol. (2003) [Pubmed]
  4. Role of four major cellulases in triggering of cellulase gene expression by cellulose in Trichoderma reesei. Seiboth, B., Hakola, S., Mach, R.L., Suominen, P.L., Kubicek, C.P. J. Bacteriol. (1997) [Pubmed]
  5. Isolation and properties of an extracellular beta-glucosidase from the polycentric rumen fungus Orpinomyces sp. strain PC-2. Chen, H., Li, X., Ljungdahl, L.G. Appl. Environ. Microbiol. (1994) [Pubmed]
  6. Regulation of the cellulolytic system in Trichoderma reesei by sophorose: induction of cellulase and repression of beta-glucosidase. Sternberg, D., Mandels, G.R. J. Bacteriol. (1980) [Pubmed]
  7. Induction of cellulolytic enzymes in Trichoderma reesei by sophorose. Sternberg, D., Mandels, G.R. J. Bacteriol. (1979) [Pubmed]
  8. Cytochromes P450 of the sophorose lipid-producing yeast Candida apicola: heterogeneity and polymerase chain reaction-mediated cloning of two genes. Lottermoser, K., Schunck, W.H., Asperger, O. Yeast (1996) [Pubmed]
  9. Functional analysis of the cellobiohydrolase I promoter of the filamentous fungus Trichoderma reesei. Ilmén, M., Onnela, M.L., Klemsdal, S., Keränen, S., Penttilä, M. Mol. Gen. Genet. (1996) [Pubmed]
  10. Construction and characterization of chimeric enzymes of kojibiose phosphorylase and trehalose phosphorylase from Thermoanaerobacter brockii. Yamamoto, T., Yamashita, H., Mukai, K., Watanabe, H., Kubota, M., Chaen, H., Fukuda, S. Carbohydr. Res. (2006) [Pubmed]
  11. Involvement of a conidial endoglucanase and a plasma-membrane-bound beta-glucosidase in the induction of endoglucanase synthesis by cellulose in Trichoderma reesei. Kubicek, C.P. J. Gen. Microbiol. (1987) [Pubmed]
  12. Sophorose metabolism and cellulase induction in Trichoderma. Loewenberg, J.R., Chapman, C.M. Arch. Microbiol. (1977) [Pubmed]
  13. Sophorose induction of an intracellular b-glucosidase in Trichoderma. Loewenberg, J.R. Arch. Microbiol. (1984) [Pubmed]
  14. The enzymatic synthesis of beta 1-2 glucans. Zorreguieta, A., Tolmasky, M.E., Staneloni, R.J. Arch. Biochem. Biophys. (1985) [Pubmed]
  15. Purification and characterization of an extracellular beta-glucosidase from the filamentous fungus Acremonium persicinum and its probable role in beta-glucan degradation. Pitson, S.M., Seviour, R.J., McDougall, B.M. Enzyme Microb. Technol. (1997) [Pubmed]
  16. L-Sorbose induces cellulase gene transcription in the cellulolytic fungus Trichoderma reesei. Nogawa, M., Goto, M., Okada, H., Morikawa, Y. Curr. Genet. (2001) [Pubmed]
  17. The protein disulphide isomerase gene of the fungus Trichoderma reesei is induced by endoplasmic reticulum stress and regulated by the carbon source. Saloheimo, M., Lund, M., Penttilä, M.E. Mol. Gen. Genet. (1999) [Pubmed]
  18. Transfer of high-mannose-type oligosaccharides to disaccharides by endo-beta-N-acetylglucosaminidase from Arthrobacter protophormiae. Fujita, K., Miyamura, T., Sano, M., Kato, I., Takegawa, K. J. Biosci. Bioeng. (2002) [Pubmed]
  19. Cloning of genes expressed early during cellulase induction in Hypocrea jecorina by a rapid subtraction hybridization approach. Schmoll, M., Zeilinger, S., Mach, R.L., Kubicek, C.P. Fungal Genet. Biol. (2004) [Pubmed]
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