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Chemical Compound Review

AC1Q4UMG     9-thia-7,8- diazabicyclo[4.3.0]nona- 2,4,7...

Synonyms: AR-1F1537, AC1L3QI2, 3a,7a-dihydro-1,2,3-benzothiadiazole
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Disease relevance of Benzothiadiazole

  • Upon infection by Pseudomonas syringae or Hyaloperonospora parasitica, priming conferred levels of disease protection that almost equaled the protection in benzothiadiazole-treated wild-type plants and cpr1 plants [1].

Psychiatry related information on Benzothiadiazole


High impact information on Benzothiadiazole

  • Whole genome transcriptional profiling showed that in the sni1 mutant, Nonexpresser of PR genes (NPR1)-dependent benzothiadiazole S-methylester-responsive genes were specifically derepressed [3].
  • Furthermore, the application of the SA functional analog benzothiadiazole enhanced disease resistance in the sfd1 mutant plants [4].
  • Furthermore, exogenous application of BTH restored PDF1.2 expression in these plants [5].
  • Application of the systemic acquired resistance activator benzothiadiazole (BTH) in combination with these fungicides results in a synergistic effect on pathogen resistance in wild-type plants and an additive effect in NahG and BTH-unresponsive nim1 plants [2].
  • Benzothiadiazole, a novel class of inducers of systemic acquired resistance, activates gene expression and disease resistance in wheat [6].

Chemical compound and disease context of Benzothiadiazole


Biological context of Benzothiadiazole

  • It was found that the efficient energy transfer occurs by exciton trapping on the narrow band gap BTDZ site under UV illumination [8].
  • Induction of systemic resistance to Pythium damping-off in cucumber plants by benzothiadiazole: ultrastructure and cytochemistry of the host response [9].
  • Expression of OsBIMK1 was induced rapidly during the first 36 h after inoculation with M. grisea in BTH-treated rice seedlings and in an incompatible interaction between M. grisea and a blast-resistant rice genotype [7].
  • We have isolated from rice a new MAPK cDNA, OsBIMK1 ( O ryza s ativa L. BTH-induced MAPK 1), which encodes a 369-amino-acid protein with moderate to high nucleotide sequence similarity to previously reported plant MAPK genes [7].
  • The X-ray crystallographic analysis of the compounds containing a benzothiadiazole ring revealed nonplanar molecular structures and unique crystal structures depending on the nitrogen positions [10].

Anatomical context of Benzothiadiazole

  • The results indicate that both benzothiadiazole and salicylic acid affect the mitochondria of treated plant cells and result in increased production of reactive oxygen species [11].
  • Microscopic analysis revealed that BTH treatment could prevent penetration of the odium germ tube through the epidermal cell wall of tobacco leaves whereas penetration was successful on tomato leaves, irrespective of BTH treatment [12].

Associations of Benzothiadiazole with other chemical compounds


Gene context of Benzothiadiazole

  • We isolated and identified four rice genes, OsBIERF1 to OsBIERF4 (Oryza sativa benzothiadiazole (BTH)-induced ethylene responsive transcriptional factors (ERF)) and analyzed their expressions in rice disease resistance response and under various abiotic stress conditions [14].

Analytical, diagnostic and therapeutic context of Benzothiadiazole


  1. Costs and benefits of priming for defense in Arabidopsis. van Hulten, M., Pelser, M., van Loon, L.C., Pieterse, C.M., Ton, J. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  2. Impaired fungicide activity in plants blocked in disease resistance signal transduction. Molina, A., Hunt, M.D., Ryals, J.A. Plant Cell (1998) [Pubmed]
  3. A comprehensive structure-function analysis of Arabidopsis SNI1 defines essential regions and transcriptional repressor activity. Mosher, R.A., Durrant, W.E., Wang, D., Song, J., Dong, X. Plant Cell (2006) [Pubmed]
  4. The Arabidopsis thaliana dihydroxyacetone phosphate reductase gene SUPPRESSSOR OF FATTY ACID DESATURASE DEFICIENCY1 is required for glycerolipid metabolism and for the activation of systemic acquired resistance. Nandi, A., Welti, R., Shah, J. Plant Cell (2004) [Pubmed]
  5. The Arabidopsis ssi1 mutation restores pathogenesis-related gene expression in npr1 plants and renders defensin gene expression salicylic acid dependent. Shah, J., Kachroo, P., Klessig, D.F. Plant Cell (1999) [Pubmed]
  6. Benzothiadiazole, a novel class of inducers of systemic acquired resistance, activates gene expression and disease resistance in wheat. Görlach, J., Volrath, S., Knauf-Beiter, G., Hengy, G., Beckhove, U., Kogel, K.H., Oostendorp, M., Staub, T., Ward, E., Kessmann, H., Ryals, J. Plant Cell (1996) [Pubmed]
  7. OsBIMK1, a rice MAP kinase gene involved in disease resistance responses. Song, F., Goodman, R.M. Planta (2002) [Pubmed]
  8. High-efficiency, environment-friendly electroluminescent polymers with stable high work function metal as a cathode: green- and yellow-emitting conjugated polyfluorene polyelectrolytes and their neutral precursors. Huang, F., Hou, L., Wu, H., Wang, X., Shen, H., Cao, W., Yang, W., Cao, Y. J. Am. Chem. Soc. (2004) [Pubmed]
  9. Induction of systemic resistance to Pythium damping-off in cucumber plants by benzothiadiazole: ultrastructure and cytochemistry of the host response. Benhamou, N., Bélanger, R.R. Plant J. (1998) [Pubmed]
  10. Synthesis and characterization of novel dipyridylbenzothiadiazole and bisbenzothiadiazole derivatives. Akhtaruzzaman, M., Tomura, M., Nishida, J., Yamashita, Y. J. Org. Chem. (2004) [Pubmed]
  11. Benzothiadiazole inhibits mitochondrial NADH:ubiquinone oxidoreductase in tobacco. van der Merwe, J.A., Dubery, I.A. J. Plant Physiol. (2006) [Pubmed]
  12. The SA-dependent defense pathway is active against different pathogens in tomato and tobacco. Achuo, A.E., Audenaert, K., Meziane, H., Höfte, M. Mededelingen (Rijksuniversiteit te Gent. Fakulteit van de Landbouwkundige en Toegepaste Biologische Wetenschappen) (2002) [Pubmed]
  13. Spent growth medium of Pantoea agglomerans primes wheat suspension cells for augmented accumulation of hydrogen peroxide and enhanced peroxidase activity upon elicitation. Ortmann, I., Moerschbacher, B.M. Planta (2006) [Pubmed]
  14. Molecular characterization of four rice genes encoding ethylene-responsive transcriptional factors and their expressions in response to biotic and abiotic stress. Cao, Y., Song, F., Goodman, R.M., Zheng, Z. J. Plant Physiol. (2006) [Pubmed]
  15. Up-regulation of OsBIHD1, a rice gene encoding BELL homeodomain transcriptional factor, in disease resistance responses. Luo, H., Song, F., Goodman, R.M., Zheng, Z. Plant biology (Stuttgart, Germany) (2005) [Pubmed]
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