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Chemical Compound Review

Brietal     sodium5-hex-3-yn-2-yl-1- methyl-4,6-dioxo...

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Disease relevance of Methohexitone


Psychiatry related information on Methohexitone


High impact information on Methohexitone

  • PURPOSES: We report our experience with sodium methohexital (Brevital) as an anesthetic used in the Wada test for language and memory in 86 epilepsy surgery patients (173 procedures) [5].
  • 1. Male, Wistar rats were treated with streptozotocin (STZ, 70 mg kg-1, i.p.) or saline and chronically instrumented with pulsed Doppler probes and intravascular catheters (implanted under sodium methohexitone anaesthesia) to allow assessment of haemodynamics in the conscious state 28 days later [6].
  • Preliminary observations on the effects of hydrocortisone and sodium methohexital on development of Sarcophaga (Curranea) tibialis Macquart (Diptera: Sarcophagidae), and implications for estimating post mortem interval [7].
  • Twenty-four hours after a 30 percent body surface contact burn (Brevital anesthesia) and a 48-hour fast with saline and ten percent dextrose ad libitim gastric secretions were collected for two hours following pyloric ligation under urethan anesthesia [8].
  • Anesthetized toads (Brevital sodium; 40 mg/kg im) were fitted with a cloacal thermistor and femoral artery cannula [9].

Associations of Methohexitone with other chemical compounds


Analytical, diagnostic and therapeutic context of Methohexitone


  1. Angiotensinogen and AT(1) antisense inhibition of osteopontin translation in rat proximal tubular cells. Ricardo, S.D., Franzoni, D.F., Roesener, C.D., Crisman, J.M., Diamond, J.R. Am. J. Physiol. Renal Physiol. (2000) [Pubmed]
  2. Intraarterial use of sodium methohexital for provocative testing during brain embolotherapy. Peters, K.R., Quisling, R.G., Gilmore, R., Mickle, P., Kuperus, J.H. AJNR. American journal of neuroradiology. (1993) [Pubmed]
  3. Successful resuscitation of a child with severe hypothermia after cardiac arrest of 88 minutes. Schmidt, U., Fritz, K.W., Kasperczyk, W., Tscherne, H. Prehospital and disaster medicine : the official journal of the National Association of EMS Physicians and the World Association for Emergency and Disaster Medicine in association with the Acute Care Foundation. (1995) [Pubmed]
  4. Flooding with Brevital in the treatment of agoraphobia: countereffective? Chambless, D.L., Foa, E.B., Groves, G.A., Goldstein, A.J. Behaviour research and therapy. (1979) [Pubmed]
  5. Sodium methohexital (brevital) as an anesthetic in the Wada test. Buchtel, H.A., Passaro, E.A., Selwa, L.M., Deveikis, J., Gomez-Hassan, D. Epilepsia (2002) [Pubmed]
  6. Selective impairment of hindquarters vasodilator responses to bradykinin in conscious Wistar rats with streptozotocin-induced diabetes mellitus. Kiff, R.J., Gardiner, S.M., Compton, A.M., Bennett, T. Br. J. Pharmacol. (1991) [Pubmed]
  7. Preliminary observations on the effects of hydrocortisone and sodium methohexital on development of Sarcophaga (Curranea) tibialis Macquart (Diptera: Sarcophagidae), and implications for estimating post mortem interval. Musvasva, E., Williams, K.A., Muller, W.J., Villet, M.H. Forensic Sci. Int. (2001) [Pubmed]
  8. H+ back diffusion and peptic activity related to ulcerogenesis following thermal injury. Tichy, A. Nursing research. (1978) [Pubmed]
  9. Effect of hematocrit on behavioral thermoregulation of the toad Bufo marinus. Wood, S.C. Am. J. Physiol. (1990) [Pubmed]
  10. Pro- and anticonvulsant effects of anesthetics (Part II). Modica, P.A., Tempelhoff, R., White, P.F. Anesth. Analg. (1990) [Pubmed]
  11. Combined activation of the EEG with brietal and pentetrazol. Ghazy, A., Lundervold, A., Veger, T. Clinical EEG (electroencephalography). (1978) [Pubmed]
  12. Monitoring sodium methohexital distribution with [99mTc]HMPAO with single photon emission computed tomography during Wada test. Coubes, P., Baldy-Moulinier, M., Zanca, M., Boire, J.Y., Child, R., Bourbotte, G., Frerebeau, P. Epilepsia (1995) [Pubmed]
  13. Lack of influence of brain catecholamines on acute effects of barbiturates. Bourn, W.M., Reigel, C.E. Pharmacol. Biochem. Behav. (1980) [Pubmed]
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