Disease relevance of Methohexitone

• Male Sprague-Dawley rats underwent unilateral ureteral obstruction (UUO) under Brevital anesthesia [1].
• PURPOSE AND METHODS: To assess its vascular effects and safety, we used sodium methohexital (Brevital)--an ultrashort-acting barbiturate--as the provocative intraarterial agent in a series of 30 patients with arteriovenous malformations at a 1% concentration and at doses of less than 5 mg per injection [2].
• Continuous monitoring included repeated arterial blood gas and electrolyte tests; prophylaxis for cerebral edema was performed with hyperventilation and administration of sodium Brevimytal and dexamethasone [3].

Psychiatry related information on Methohexitone

• Flooding with Brevital in the treatment of agoraphobia: countereffective [4]?

High impact information on Methohexitone

• PURPOSES: We report our experience with sodium methohexital (Brevital) as an anesthetic used in the Wada test for language and memory in 86 epilepsy surgery patients (173 procedures) [5].
• 1. Male, Wistar rats were treated with streptozotocin (STZ, 70 mg kg-1, i.p.) or saline and chronically instrumented with pulsed Doppler probes and intravascular catheters (implanted under sodium methohexitone anaesthesia) to allow assessment of haemodynamics in the conscious state 28 days later [6].
• Preliminary observations on the effects of hydrocortisone and sodium methohexital on development of Sarcophaga (Curranea) tibialis Macquart (Diptera: Sarcophagidae), and implications for estimating post mortem interval [7].
• Twenty-four hours after a 30 percent body surface contact burn (Brevital anesthesia) and a 48-hour fast with saline and ten percent dextrose ad libitim gastric secretions were collected for two hours following pyloric ligation under urethan anesthesia [8].
• Anesthetized toads (Brevital sodium; 40 mg/kg im) were fitted with a cloacal thermistor and femoral artery cannula [9].

Associations of Methohexitone with other chemical compounds

• In its present formulation (Brevital; Eli Lilly, Indianapolis, Ind.), the epileptogenic properties of methohexital are limited to patients with psychomotor epilepsy [10].
• Combined activation of the EEG with brietal and pentetrazol [11].

Analytical, diagnostic and therapeutic context of Methohexitone

• Monitoring sodium methohexital distribution with [99mTc]HMPAO with single photon emission computed tomography during Wada test [12].
• None of the patients experienced either prolongation of the induced clinical symptoms or seizures to suggest any adverse effects related to either crystallization of the Brevital or the effects of injecting an alkaline solution in the cerebral circulation [2].
• Intraarterial use of sodium methohexital for provocative testing during brain embolotherapy [2].
• Rats with cerebral electrode implants were tested for sensitivity to EEG burst suppression by intravenously-infused sodium methohexital following manipulation of brain catecholamine function [13].

References