The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

Brevital     5-hex-3-yn-2-yl-1-methyl-5- prop-2-enyl-1,3...

Synonyms: Brietal, Metoesital, Metohexital, Enallynymall, METHOHEXITAL, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Methohexitone


Psychiatry related information on Methohexitone


High impact information on Methohexitone


Chemical compound and disease context of Methohexitone


Biological context of Methohexitone

  • This is not true for methohexitone, which shows comparable pharmacokinetics after single and multiple dose administration [21].
  • 4. To complement earlier studies of the inhibitory actions of anaesthetics on K(+)-evoked catecholamine secretion and the associated Ca2+ uptake, the IC50 values for etomidate and methohexitone were determined using a biochemical assay [22].
  • During methohexital anesthesia, mean arterial pressure decreased from 108 to 101 mmHg, and heart rate increased from 95 to 146 beats/min [4].
  • The mean maximum increase over baseline systolic pressure was 2.1 +/- 2.9 mmHg with propofol, and 26.7 +/- 4.5 mmHg with methohexital (P less than 0.001) [23].
  • Similarly, the plateau of the action potential prolonged by methohexital, described in this study was abolished by 50 microM saxitoxin [24].

Anatomical context of Methohexitone


Associations of Methohexitone with other chemical compounds


Gene context of Methohexitone


Analytical, diagnostic and therapeutic context of Methohexitone

  • Closed-loop feedback control of methohexital anesthesia by quantitative EEG analysis in humans [39].
  • Rectal methohexital premedication in children, a dose-comparison study [40].
  • Oral self-administration of methohexital in baboons [41].
  • Intravenous (i.v.) methohexital (MTH, Brevital) was found to have an effect on the intraoperative electrocorticogram (ECOG) of 63 patients who had temporal lobectomies performed under general anesthesia for intractable complex partial seizures [42].
  • Five CMHs and 5 AMHs were studied in a crossover study in which responses to the 41-49 degrees C stimuli were obtained first under halothane-N2O (0.8%-67%) anesthesia, then under an ultrashort acting barbiturate, methohexital (2-9 mg/kg over 15 min), and finally once again under halothane-N2O anesthesia [43].


  1. Reversible focal ischemia in the rat: effects of halothane, isoflurane, and methohexital anesthesia. Warner, D.S., Zhou, J.G., Ramani, R., Todd, M.M. J. Cereb. Blood Flow Metab. (1991) [Pubmed]
  2. Anosognosia during Wada testing. Gilmore, R.L., Heilman, K.M., Schmidt, R.P., Fennell, E.M., Quisling, R. Neurology (1992) [Pubmed]
  3. Amelioration of brain damage after 12 minutes' cardiac arrest in dogs. Safar, P., Stezoski, W., Nemoto, E.M. Arch. Neurol. (1976) [Pubmed]
  4. Methohexital impairs osmoregulation. Studies in conscious and anesthetized volume-expanded dogs. Kasner, M., Grosse, J., Krebs, M., Kaczmarczyk, G. Anesthesiology (1995) [Pubmed]
  5. Contractures elicited by tetraethylammonium in avian muscle treated with methohexitone. Elliott, R.C. Br. J. Pharmacol. (1979) [Pubmed]
  6. A comparison of propofol and methohexital as anesthetic agents for ECT: effects on seizure duration, therapeutic outcome, and memory. Mårtensson, B., Bartfai, A., Hallén, B., Hellström, C., Junthé, T., Olander, M. Biol. Psychiatry (1994) [Pubmed]
  7. Acute blocking of naloxone-precipitated opiate withdrawal symptoms by methohexitone. Loimer, N., Schmid, R., Lenz, K., Presslich, O., Grünberger, J. The British journal of psychiatry : the journal of mental science. (1990) [Pubmed]
  8. Evaluation of instrumented force platform as a test to measure residual effects of anesthetics. Korttila, K., Ghoneim, M.M., Jacobs, L., Lakes, R.S. Anesthesiology (1981) [Pubmed]
  9. Choice reaction time. A method of measuring postoperative psychomotor performance decrements. Scott, W.A., Whitwam, J.G., Wilkinson, R.T. Anaesthesia. (1983) [Pubmed]
  10. Studies of drugs given before anaesthesia XXVI: lorazepam. Dundee, J.W., Lilburn, J.K., Nair, S.G., George, K.A. British journal of anaesthesia. (1977) [Pubmed]
  11. Identification of speech lateralization by intracarotid injection of methohexital. Willmore, L.J., Wilder, B.J., Mayersdorf, A., Ramsay, R.E., Sypert, G.W. Ann. Neurol. (1978) [Pubmed]
  12. Inhibition by barbiturates of the binding of Bm3R1 repressor to its operator site on the barbiturate-inducible cytochrome P450BM-3 gene of Bacillus megaterium. Shaw, G.C., Fulco, A.J. J. Biol. Chem. (1993) [Pubmed]
  13. Anosognosia and confabulation during the Wada test. Lu, L.H., Barrett, A.M., Schwartz, R.L., Cibula, J.E., Gilmore, R.L., Uthman, B.M., Heilman, K.M. Neurology (1997) [Pubmed]
  14. CSF neuron-specific enolase after methohexital activation during electrocorticography. Rabinowicz, A.L., Correale, J.D., Couldwell, W.T., DeGiorgio, C.M. Neurology (1994) [Pubmed]
  15. Paraplegia following thoracic aortic cross-clamping in dogs. No difference in neurological outcome with a barbiturate versus isoflurane. Mutch, W.A., Graham, M.R., Halliday, W.C., Teskey, J.M., Thomson, I.R. Stroke (1993) [Pubmed]
  16. Faster recovery after anesthesia in infants after intravenous induction with methohexital instead of thiopental. Beskow, A., Werner, O., Westrin, P. Anesthesiology (1995) [Pubmed]
  17. Clonidine and methohexital-induced epileptic magnetoencephalographic discharges in patients with focal epilepsies. Kirchberger, K., Schmitt, H., Hummel, C., Peinemann, A., Pauli, E., Kettenmann, B., Stefan, H. Epilepsia (1998) [Pubmed]
  18. Sodium methohexital (brevital) as an anesthetic in the Wada test. Buchtel, H.A., Passaro, E.A., Selwa, L.M., Deveikis, J., Gomez-Hassan, D. Epilepsia (2002) [Pubmed]
  19. The measurement of occlusion pressure during anaesthesia. A comparison of the depression of respiratory drive by methohexitone and etomidate. Kay, B. Anaesthesia. (1979) [Pubmed]
  20. Pain on injection of methohexitone. The use of lignocaine to modify pain on injection of methohexitone during anaesthesia for electroconvulsive therapy. Simpson, K.H., Halsall, P.J., Sides, C.A., Keeler, J.F. Anaesthesia. (1989) [Pubmed]
  21. Clinical pharmacokinetic considerations in the treatment of increased intracranial pressure. Heinemeyer, G. Clinical pharmacokinetics. (1987) [Pubmed]
  22. Calcium channel currents in bovine adrenal chromaffin cells and their modulation by anaesthetic agents. Charlesworth, P., Pocock, G., Richards, C.D. J. Physiol. (Lond.) (1994) [Pubmed]
  23. Comparison of methohexital and propofol for electroconvulsive therapy: effects on hemodynamic responses and seizure duration. Rampton, A.J., Griffin, R.M., Stuart, C.S., Durcan, J.J., Huddy, N.C., Abbott, M.A. Anesthesiology (1989) [Pubmed]
  24. Different actions of a short-acting barbiturate on sodium and potassium conductances in invertebrate and vertebrate neurons. Johansen, J., Yang, J., Zorumski, C.F., Kleinhaus, A.L. Neuropharmacology (1989) [Pubmed]
  25. Interictal spike localisation with methohexitone: preoperative activation and surgical follow-up. Hardiman, O., Coughlan, A., O'Moore, B., Phillips, J., Staunton, H. Epilepsia (1987) [Pubmed]
  26. Recovery of evoked potential amplitude after cerebral arterial air embolism in the rabbit: a comparison of the effect of cardiopulmonary bypass with normal circulation. Hindman, B.J., Dexter, F., Enomoto, S., Subieta, A., Smith, T., Cutkomp, J. Anesthesiology (1998) [Pubmed]
  27. Thiobarbiturate-induced histamine release in human skin mast cells. Hirshman, C.A., Edelstein, R.A., Ebertz, J.M., Hanifin, J.M. Anesthesiology (1985) [Pubmed]
  28. The effects of 10% methohexital on the rectal mucosa in mice. Hinkle, A.J., Weinlander, C.M. Anesthesiology (1989) [Pubmed]
  29. Drug modification of ECT: methohexital and diazepam. II. Allen, R.E., Pitts, F.N., Summers, W.K. Biol. Psychiatry (1980) [Pubmed]
  30. The effect of fronto-frontal and temporo-parietal unilateral ECT on retrograde memory. d'Elia, G. Biol. Psychiatry (1981) [Pubmed]
  31. Propofol. A review of its pharmacodynamic and pharmacokinetic properties and use as an intravenous anaesthetic. Langley, M.S., Heel, R.C. Drugs (1988) [Pubmed]
  32. Pharmacokinetics of methohexital and thiopental in surgical patients. Hudson, R.J., Stanski, D.R., Burch, P.G. Anesthesiology (1983) [Pubmed]
  33. Outpatient premedication: use of midazolam and opioid analgesics. Shafer, A., White, P.F., Urquhart, M.L., Doze, V.A. Anesthesiology (1989) [Pubmed]
  34. The discriminative stimulus effects of N-methyl-D-aspartate antagonists in phencyclidine-trained rats. Willetts, J., Balster, R.L. Neuropharmacology (1988) [Pubmed]
  35. Comparison of rat brain and heart mitochondrial hexokinase solubilized by methohexital. Karcher, L., Rachman, A., Krieglstein, J. Naunyn Schmiedebergs Arch. Pharmacol. (1984) [Pubmed]
  36. Pharmacokinetics and clinical experience of 20-h infusions of methohexitone in intensive care patients with postoperative pyrexia. Redke, F., Björkman, S., Rosberg, B. British journal of anaesthesia. (1991) [Pubmed]
  37. Recovery after electroconvulsive therapy: comparison of propofol with methohexitone anaesthesia. Matters, R.M., Beckett, W.G., Kirkby, K.C., King, T.E. British journal of anaesthesia. (1995) [Pubmed]
  38. Barbiturates decrease the expression of vascular endothelial growth factor in hypoxic cultures of porcine brain derived microvascular endothelial cells. Fischer, S., Renz, D., Schaper, W., Karliczek, G.F. Brain Res. Mol. Brain Res. (1998) [Pubmed]
  39. Closed-loop feedback control of methohexital anesthesia by quantitative EEG analysis in humans. Schwilden, H., Schüttler, J., Stoeckel, H. Anesthesiology (1987) [Pubmed]
  40. Rectal methohexital premedication in children, a dose-comparison study. Liu, L.M., Goudsouzian, N.G., Liu, P.L. Anesthesiology (1980) [Pubmed]
  41. Oral self-administration of methohexital in baboons. Ator, N.A., Griffiths, R.R. Psychopharmacology (Berl.) (1983) [Pubmed]
  42. Methohexital (Brevital) effect on electrocorticogram may be misleading. Fiol, M.E., Torres, F., Gates, J.R., Maxwell, R. Epilepsia (1990) [Pubmed]
  43. Halothane sensitizes cutaneous nociceptors in monkeys. Campbell, J.N., Raja, S.N., Meyer, R.A. J. Neurophysiol. (1984) [Pubmed]
WikiGenes - Universities