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Gene Review

uvrD  -  DNA-dependent helicase II

Escherichia coli CFT073

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Disease relevance of uvrD


High impact information on uvrD


Chemical compound and disease context of uvrD


Biological context of uvrD


Associations of uvrD with chemical compounds

  • Two additional genes, psecoA and uvrD, border the 3' end of the cluster and are predicted to encode a coenzyme A transferase and a DNA helicase II enzyme respectively [13].

Analytical, diagnostic and therapeutic context of uvrD


  1. Evidence for a physical interaction between the Escherichia coli methyl-directed mismatch repair proteins MutL and UvrD. Hall, M.C., Jordan, J.R., Matson, S.W. EMBO J. (1998) [Pubmed]
  2. MutS and MutL activate DNA helicase II in a mismatch-dependent manner. Yamaguchi, M., Dao, V., Modrich, P. J. Biol. Chem. (1998) [Pubmed]
  3. Escherichia coli DNA helicase II is active as a monomer. Mechanic, L.E., Hall, M.C., Matson, S.W. J. Biol. Chem. (1999) [Pubmed]
  4. A point mutation in Escherichia coli DNA helicase II renders the enzyme nonfunctional in two DNA repair pathways. Evidence for initiation of unwinding from a nick in vivo. Brosh, R.M., Matson, S.W. J. Biol. Chem. (1997) [Pubmed]
  5. Mutation of a highly conserved arginine in motif IV of Escherichia coli DNA helicase II results in an ATP-binding defect. Hall, M.C., Matson, S.W. J. Biol. Chem. (1997) [Pubmed]
  6. A partially functional DNA helicase II mutant defective in forming stable binary complexes with ATP and DNA. A role for helicase motif III. Brosh, R.M., Matson, S.W. J. Biol. Chem. (1996) [Pubmed]
  7. A dominant negative allele of the Escherichia coli uvrD gene encoding DNA helicase II. A biochemical and genetic characterization. George, J.W., Brosh, R.M., Matson, S.W. J. Mol. Biol. (1994) [Pubmed]
  8. Mutations in motif II of Escherichia coli DNA helicase II render the enzyme nonfunctional in both mismatch repair and excision repair with differential effects on the unwinding reaction. Brosh, R.M., Matson, S.W. J. Bacteriol. (1995) [Pubmed]
  9. Identification and characterization of Escherichia coli DNA helicase II mutants that exhibit increased unwinding efficiency. Zhang, G., Deng, E., Baugh, L., Kushner, S.R. J. Bacteriol. (1998) [Pubmed]
  10. Inhibition of DNA helicase II unwinding and ATPase activities by DNA-interacting ligands. Kinetics and specificity. George, J.W., Ghate, S., Matson, S.W., Besterman, J.M. J. Biol. Chem. (1992) [Pubmed]
  11. Studies on the functions of DNA helicase I and DNA helicase II of Escherichia coli. Klinkert, M.Q., Klein, A., Abdel-Monem, M. J. Biol. Chem. (1980) [Pubmed]
  12. Kinetics of ATP hydrolysis during the DNA helicase II-promoted unwinding of duplex DNA. Yodh, J.G., Bryant, F.R. Biochemistry (1993) [Pubmed]
  13. Three rhamnosyltransferases responsible for assembly of the A-band D-rhamnan polysaccharide in Pseudomonas aeruginosa: a fourth transferase, WbpL, is required for the initiation of both A-band and B-band lipopolysaccharide synthesis. Rocchetta, H.L., Burrows, L.L., Pacan, J.C., Lam, J.S. Mol. Microbiol. (1998) [Pubmed]
  14. The MutL ATPase is required for mismatch repair. Spampinato, C., Modrich, P. J. Biol. Chem. (2000) [Pubmed]
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