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Gene Review

ECs3688  -  DNA mismatch repair protein

Escherichia coli O157:H7 str. Sakai

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Disease relevance of ECs3688


High impact information on ECs3688


Chemical compound and disease context of ECs3688


Biological context of ECs3688


Associations of ECs3688 with chemical compounds

  • Our data show that the intermediates of uracil repair cannot substitute for the strand-discrimination signals generated by the MutH protein, which is thought to initiate the methyl-directed mismatch repair process by nicking the unmethylated strand of a newly-synthesized DNA duplex at d(GATC) sites [11].

Other interactions of ECs3688


Analytical, diagnostic and therapeutic context of ECs3688


  1. Evidence for a physical interaction between the Escherichia coli methyl-directed mismatch repair proteins MutL and UvrD. Hall, M.C., Jordan, J.R., Matson, S.W. EMBO J. (1998) [Pubmed]
  2. Altering the conserved nucleotide binding motif in the Salmonella typhimurium MutS mismatch repair protein affects both its ATPase and mismatch binding activities. Haber, L.T., Walker, G.C. EMBO J. (1991) [Pubmed]
  3. Cooperation and competition in mismatch repair: very short-patch repair and methyl-directed mismatch repair in Escherichia coli. Bhagwat, A.S., Lieb, M. Mol. Microbiol. (2002) [Pubmed]
  4. A genetic analysis of primary products of bacteriophage lambda recombination. Huisman, O., Fox, M.S. Genetics (1986) [Pubmed]
  5. Demonstration and characterization of mutations induced by Helicobacter pylori organisms in gastric epithelial cells. Yao, Y., Tao, H., Park, D.I., Sepulveda, J.L., Sepulveda, A.R. Helicobacter (2006) [Pubmed]
  6. High mutation frequencies among Escherichia coli and Salmonella pathogens. LeClerc, J.E., Li, B., Payne, W.L., Cebula, T.A. Science (1996) [Pubmed]
  7. Mutation detection with MutH, MutL, and MutS mismatch repair proteins. Smith, J., Modrich, P. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  8. Stabilization of diverged tandem repeats by mismatch repair: evidence for deletion formation via a misaligned replication intermediate. Lovett, S.T., Feschenko, V.V. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  9. Escherichia coli DNA helicase II (uvrD gene product) catalyzes the unwinding of DNA.RNA hybrids in vitro. Matson, S.W. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  10. Redundant exonuclease involvement in Escherichia coli methyl-directed mismatch repair. Viswanathan, M., Burdett, V., Baitinger, C., Modrich, P., Lovett, S.T. J. Biol. Chem. (2001) [Pubmed]
  11. Effect of uracil situated in the vicinity of a mispair on the directionality of mismatch correction in Escherichia coli. Aprelikova, O., Jiricny, J. Nucleic Acids Res. (1991) [Pubmed]
  12. Response of repair-competent and repair-deficient Escherichia coli to three O6-substituted guanines and involvement of methyl-directed mismatch repair in the processing of O6-methylguanine residues. Pauly, G.T., Hughes, S.H., Moschel, R.C. Biochemistry (1994) [Pubmed]
  13. Effects of high levels of DNA adenine methylation on methyl-directed mismatch repair in Escherichia coli. Pukkila, P.J., Peterson, J., Herman, G., Modrich, P., Meselson, M. Genetics (1983) [Pubmed]
  14. MutL-catalyzed ATP hydrolysis is required at a post-UvrD loading step in methyl-directed mismatch repair. Robertson, A.B., Pattishall, S.R., Gibbons, E.A., Matson, S.W. J. Biol. Chem. (2006) [Pubmed]
  15. Mispair specificity of methyl-directed DNA mismatch correction in vitro. Su, S.S., Lahue, R.S., Au, K.G., Modrich, P. J. Biol. Chem. (1988) [Pubmed]
  16. A dominant negative allele of the Escherichia coli uvrD gene encoding DNA helicase II. A biochemical and genetic characterization. George, J.W., Brosh, R.M., Matson, S.W. J. Mol. Biol. (1994) [Pubmed]
  17. Length of CTG.CAG repeats determines the influence of mismatch repair on genetic instability. Parniewski, P., Jaworski, A., Wells, R.D., Bowater, R.P. J. Mol. Biol. (2000) [Pubmed]
  18. Site-specific frame-shift mutagenesis by the 1-nitropyrene-DNA adduct N-(deoxyguanosin-8-y1)-1-aminopyrene located in the (CG)3 sequence: effects of SOS, proofreading, and mismatch repair. Malia, S.A., Vyas, R.R., Basu, A.K. Biochemistry (1996) [Pubmed]
  19. Cloning of enterohemorrhagic Escherichia coli phage VT-2 dam methyltransferase. Radlinska, M., Bujnicki, J.M. Acta Microbiol. Pol. (2001) [Pubmed]
  20. Bidirectional excision in methyl-directed mismatch repair. Grilley, M., Griffith, J., Modrich, P. J. Biol. Chem. (1993) [Pubmed]
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