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Gene Review

aidB  -  isovaleryl CoA dehydrogenase

Escherichia coli CFT073

 
 
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Disease relevance of aidB

 

High impact information on aidB

 

Chemical compound and disease context of aidB

 

Biological context of aidB

  • However, sigma s-dependent transcription of aidB is inhibited both in vitro and in vivo by binding of the transcriptional regulator Lrp (leucine responsive protein) to the aidB promoter region (PaidB) [2].
  • In this note we present evidence that aidB is induced by anaerobiosis [8].
  • The Escherichia coli aidB gene is a component of the adaptive response to alkylation damage [6].
  • These results indicate that the sulfate transport genes perform a role in anaerobic induction of the aidB gene and suggest that growth under anaerobic conditions may modify either the function or the expression of gene products encoded by the cysA operon [6].
 

Associations of aidB with chemical compounds

  • On the basis of its ability to bind DNA and its possession of a redox-active flavin, AidB is predicted to catalyze the direct repair of alkylated DNA [5].
  • In order to begin to identify the role of AidB in the cell, the protein was purified to homogeneity, shown to possess stoichiometric amounts of flavin adenine dinucleotide (FAD), and confirmed to have low levels of isovaleryl-coenzyme A (CoA) dehydrogenase activity [5].

References

  1. RNA polymerase alpha subunit binding site in positively controlled promoters: a new model for RNA polymerase-promoter interaction and transcriptional activation in the Escherichia coli ada and aidB genes. Landini, P., Volkert, M.R. EMBO J. (1995) [Pubmed]
  2. The leucine-responsive regulatory protein (Lrp) acts as a specific repressor for sigma s-dependent transcription of the Escherichia coli aidB gene. Landini, P., Hajec, L.I., Nguyen, L.H., Burgess, R.R., Volkert, M.R. Mol. Microbiol. (1996) [Pubmed]
  3. Identification and expression of the SOS response, aidB-like, gene in the marine sponge Geodia cydonium: implication for the phylogenetic relationships of metazoan acyl-CoA dehydrogenases and acyl-CoA oxidases. Krasko, A., Schröder, H.C., Hassanein, H.M., Batel, R., Müller, I.M., Müller, W.E. J. Mol. Evol. (1998) [Pubmed]
  4. Transcriptional activation of the Escherichia coli adaptive response gene aidB is mediated by binding of methylated Ada protein. Evidence for a new consensus sequence for Ada-binding sites. Landini, P., Volkert, M.R. J. Biol. Chem. (1995) [Pubmed]
  5. The AidB component of the Escherichia coli adaptive response to alkylating agents is a flavin-containing, DNA-binding protein. Rohankhedkar, M.S., Mulrooney, S.B., Wedemeyer, W.J., Hausinger, R.P. J. Bacteriol. (2006) [Pubmed]
  6. Anaerobic induction of the alkylation-inducible Escherichia coli aidB gene involves genes of the cysteine biosynthetic pathway. Matijasević, Z., Hajec, L.I., Volkert, M.R. J. Bacteriol. (1992) [Pubmed]
  7. Induction of the alkylation-inducible aidB gene of Escherichia coli by cytoplasmic acidification and N-ethylmaleimide. Smirnova, G.V., Oktyabrsky, O.N., Moshonkina, E.V., Zakirova, N.V. Mutat. Res. (1994) [Pubmed]
  8. Induction of the alkylation-inducible aidB gene of Escherichia coli by anaerobiosis. Volkert, M.R., Hajec, L.I., Nguyen, D.C. J. Bacteriol. (1989) [Pubmed]
 
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