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Gene Review

STK25  -  serine/threonine kinase 25

Homo sapiens

Synonyms: SOK-1, SOK1, Serine/threonine-protein kinase 25, Ste20-like kinase, Ste20/oxidant stress response kinase 1, ...
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Disease relevance of STK25

  • STK25 is a candidate gene for pseudopseudohypoparathyroidism [1].
  • We also find that a cleaved form of SOK1 translocates from the Golgi to the nucleus after chemical anoxia and that this translocation is dependent on both caspase activity and on amino acids 275-292, located immediately C-terminal to the SOK1 kinase domain [2].

High impact information on STK25


Biological context of STK25


Anatomical context of STK25


  1. STK25 is a candidate gene for pseudopseudohypoparathyroidism. Davids, M.S., Crawford, E., Weremowicz, S., Morton, C.C., Copeland, N.G., Gilbert, D.J., Jenkins, N.A., Phelan, M.C., Comb, M.J., Melnick, M.B. Genomics (2001) [Pubmed]
  2. SOK1 translocates from the Golgi to the nucleus upon chemical anoxia and induces apoptotic cell death. Nogueira, E., Fidalgo, M., Molnar, A., Kyriakis, J., Force, T., Zalvide, J., Pombo, C.M. J. Biol. Chem. (2008) [Pubmed]
  3. YSK1 is activated by the Golgi matrix protein GM130 and plays a role in cell migration through its substrate 14-3-3zeta. Preisinger, C., Short, B., De Corte, V., Bruyneel, E., Haas, A., Kopajtich, R., Gettemans, J., Barr, F.A. J. Cell Biol. (2004) [Pubmed]
  4. Caspase cleavage of MST1 promotes nuclear translocation and chromatin condensation. Ura, S., Masuyama, N., Graves, J.D., Gotoh, Y. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  5. Poly(ADP-ribose) polymerase 1 and Ste20-like kinase hKFC act as transcriptional repressors for gamma-2 herpesvirus lytic replication. Gwack, Y., Nakamura, H., Lee, S.H., Souvlis, J., Yustein, J.T., Gygi, S., Kung, H.J., Jung, J.U. Mol. Cell. Biol. (2003) [Pubmed]
  6. Regulation of mammalian STE20-like kinase 2 (MST2) by protein phosphorylation/dephosphorylation and proteolysis. Deng, Y., Pang, A., Wang, J.H. J. Biol. Chem. (2003) [Pubmed]
  7. Molecular delineation of deletions on 2q37.3 in three cases with an Albright hereditary osteodystrophy-like phenotype. Shrimpton, A.E., Braddock, B.R., Thomson, L.L., Stein, C.K., Hoo, J.J. Clin. Genet. (2004) [Pubmed]
  8. Phosphorylation and dimerization regulate nucleocytoplasmic shuttling of mammalian STE20-like kinase (MST). Lee, K.K., Yonehara, S. J. Biol. Chem. (2002) [Pubmed]
  9. Sodium arsenite-induced stress-related gene expression in normal human epidermal, HaCaT, and HEL30 keratinocytes. Trouba, K.J., Geisenhoffer, K.M., Germolec, D.R. Environ. Health Perspect. (2002) [Pubmed]
  10. KFC, a Ste20-like kinase with mitogenic potential and capability to activate the SAPK/JNK pathway. Yustein, J.T., Li, D., Robinson, D., Kung, H.J. Oncogene (2000) [Pubmed]
  11. The 3'-untranslated region of the Ste20-like kinase SLK regulates SLK expression. Cybulsky, A.V., Takano, T., Papillon, J., Hao, W., Mancini, A., Di Battista, J.A., Cybulsky, M.I. Am. J. Physiol. Renal Physiol. (2007) [Pubmed]
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