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Gene Review

TACC2  -  transforming, acidic coiled-coil...

Homo sapiens

Synonyms: AZU-1, Anti-Zuai-1, ECTACC, Transforming acidic coiled-coil-containing protein 2
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Disease relevance of TACC2


High impact information on TACC2

  • Finally, in TACC2-deficient embryonic fibroblasts, proliferation and cell cycle progression as well as centrosome numbers are comparable to those in wild-type cells [1].
  • Therefore, TACC2 is not required, nonredundantly, for mouse development and normal cell proliferation and is not a tumor suppressor protein [1].
  • In addition, reexpression of AZU-1 in T4-2 cells, using viral vectors, was sufficient to reduce their malignant phenotype substantially, both in culture and in vivo [2].
  • These results indicate that AZU-1 is a candidate breast tumor suppressor that may exert its effects by promoting correct tissue morphogenesis [2].
  • The AZU-1 gene encodes an acidic 571-amino-acid protein containing at least two structurally distinct domains with potential protein-binding functions: an N-terminal serine and proline-rich domain with a predicted immunoglobulin-like fold and a C-terminal coiled-coil domain [2].

Biological context of TACC2


Anatomical context of TACC2

  • In addition, the distance between two centrosomes was markedly reduced, suggesting that centrosomal TACC2 is required for mitotic spindle maintenance [4].
  • Cloning and structural characterization of ECTACC, a new member of the transforming acidic coiled coil (TACC) gene family: cDNA sequence and expression analysis in human microvascular endothelial cells [3].

Other interactions of TACC2


Analytical, diagnostic and therapeutic context of TACC2


  1. The centrosomal, putative tumor suppressor protein TACC2 is dispensable for normal development, and deficiency does not lead to cancer. Schuendeln, M.M., Piekorz, R.P., Wichmann, C., Lee, Y., McKinnon, P.J., Boyd, K., Takahashi, Y., Ihle, J.N. Mol. Cell. Biol. (2004) [Pubmed]
  2. AZU-1: a candidate breast tumor suppressor and biomarker for tumor progression. Chen, H.M., Schmeichel, K.L., Mian, I.S., Lelièvre, S., Petersen, O.W., Bissell, M.J. Mol. Biol. Cell (2000) [Pubmed]
  3. Cloning and structural characterization of ECTACC, a new member of the transforming acidic coiled coil (TACC) gene family: cDNA sequence and expression analysis in human microvascular endothelial cells. Pu, J.J., Li, C., Rodriguez, M., Banerjee, D. Cytokine (2001) [Pubmed]
  4. TTK kinase is essential for the centrosomal localization of TACC2. Dou, Z., Ding, X., Zereshki, A., Zhang, Y., Zhang, J., Wang, F., Sun, J., Huang, H., Yao, X. FEBS Lett. (2004) [Pubmed]
  5. Molecular cloning, genomic structure and interactions of the putative breast tumor suppressor TACC2. Lauffart, B., Gangisetty, O., Still, I.H. Genomics (2003) [Pubmed]
  6. TACC3 expression is tightly regulated during early differentiation. Sadek, C.M., Pelto-Huikko, M., Tujague, M., Steffensen, K.R., Wennerholm, M., Gustafsson, J.A. Gene Expr. Patterns (2003) [Pubmed]
  7. The transforming acidic coiled coil proteins interact with nuclear histone acetyltransferases. Gangisetty, O., Lauffart, B., Sondarva, G.V., Chelsea, D.M., Still, I.H. Oncogene (2004) [Pubmed]
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